Occult HBV infection among a cohort of Nigerian adults
Objective: To determine markers of HBV infection and detect the presence of its occult infection in serum of a cohort of adult Nigerians. Methodology: The study involved 28 adult Nigerians with viral hepatitis (Group 1) and 28 apparently healthy adult Nigerians as controls (Group 2). Their sera were...
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The Journal of Infection in Developing Countries
2009-07-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/415 |
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| author | Samuel O. Ola Jesse A. Otegbayo Georgina N. Odaibo David O. Olaleye Itunu O. Olubuyide Christopher B. Summerton Elijah A. Bamgboye |
| author_facet | Samuel O. Ola Jesse A. Otegbayo Georgina N. Odaibo David O. Olaleye Itunu O. Olubuyide Christopher B. Summerton Elijah A. Bamgboye |
| author_sort | Samuel O. Ola |
| collection | DOAJ |
| description | Objective: To determine markers of HBV infection and detect the presence of its occult infection in serum of a cohort of adult Nigerians.
Methodology: The study involved 28 adult Nigerians with viral hepatitis (Group 1) and 28 apparently healthy adult Nigerians as controls (Group 2). Their sera were assayed for HBsAg, HBeAg, anti-HBe, anti-HBc, anti-HBs, and anti-HCV, while HBV DNA was determined in 15 patients with chronic hepatitis. Significance of differences between the patients and control subjects was assessed using Chi-square test at a 95% confidence level.
Results: Sero-detection of HBsAg, HBeAg, anti-HBe and anti-HBc was higher among the patients compared to the controls. HBV infection was diagnosed by HBsAg (89%) and a duo of HBsAg and anti-HBc (100%) among the patients. Similarly, eleven and four types of different patterns of HBV markers were observed among the respective groups. Anti-HBe (9.5%), anti-HBc (14.3%), and anti-HBs (9.5%) were detected among all the subjects who were sero-negative for HBsAg. HBV DNA was also detected in 86.7% of the 15 patients with chronic hepatitis, while occult HBV infection was observed in 7.2% of the patients and none (0%) of the controls, p < 0.05. Furthermore, HCV infection occurred among subjects with all the different patterns of HBV markers, except those with occult HBV infection and natural immunity to HBV.
Conclusion: This study shows that occult HBV infection is present among Nigerian adults and determination of HBsAg, anti-HBc, anti-HBe, and HBV DNA will assist in its detection. |
| format | Article |
| id | doaj-art-cd2cf7698ae74f4ba5ea423edb1817a8 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2009-07-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-cd2cf7698ae74f4ba5ea423edb1817a82025-08-20T02:16:18ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802009-07-0130610.3855/jidc.415Occult HBV infection among a cohort of Nigerian adultsSamuel O. Ola0Jesse A. Otegbayo1Georgina N. Odaibo2David O. Olaleye3Itunu O. Olubuyide4Christopher B. Summerton5Elijah A. Bamgboye6Department of Medicine, College of Medicine, University of Ibadan, University College Hospital, IbadanDepartment of Medicine, College of Medicine, University of Ibadan, University College Hospital, IbadanDepartment of Virology and Epidemiology, College of Medicine, University of Ibadan, University College Hospital, IbadanDepartment of Virology and Epidemiology, College of Medicine, University of Ibadan, University College Hospital, IbadanDepartment of Medicine, College of Medicine, University of Ibadan, University College Hospital, IbadanDepartment of Gastroenterology, Trafford General, Hospital, Davyhulme, ManchesterDepartment of Medical Statistic and Environmental Health, College of Medicine, University of Ibadan, University College Hospital, IbadanObjective: To determine markers of HBV infection and detect the presence of its occult infection in serum of a cohort of adult Nigerians. Methodology: The study involved 28 adult Nigerians with viral hepatitis (Group 1) and 28 apparently healthy adult Nigerians as controls (Group 2). Their sera were assayed for HBsAg, HBeAg, anti-HBe, anti-HBc, anti-HBs, and anti-HCV, while HBV DNA was determined in 15 patients with chronic hepatitis. Significance of differences between the patients and control subjects was assessed using Chi-square test at a 95% confidence level. Results: Sero-detection of HBsAg, HBeAg, anti-HBe and anti-HBc was higher among the patients compared to the controls. HBV infection was diagnosed by HBsAg (89%) and a duo of HBsAg and anti-HBc (100%) among the patients. Similarly, eleven and four types of different patterns of HBV markers were observed among the respective groups. Anti-HBe (9.5%), anti-HBc (14.3%), and anti-HBs (9.5%) were detected among all the subjects who were sero-negative for HBsAg. HBV DNA was also detected in 86.7% of the 15 patients with chronic hepatitis, while occult HBV infection was observed in 7.2% of the patients and none (0%) of the controls, p < 0.05. Furthermore, HCV infection occurred among subjects with all the different patterns of HBV markers, except those with occult HBV infection and natural immunity to HBV. Conclusion: This study shows that occult HBV infection is present among Nigerian adults and determination of HBsAg, anti-HBc, anti-HBe, and HBV DNA will assist in its detection.https://jidc.org/index.php/journal/article/view/415occult HBV infectionHCVNigerians |
| spellingShingle | Samuel O. Ola Jesse A. Otegbayo Georgina N. Odaibo David O. Olaleye Itunu O. Olubuyide Christopher B. Summerton Elijah A. Bamgboye Occult HBV infection among a cohort of Nigerian adults Journal of Infection in Developing Countries occult HBV infection HCV Nigerians |
| title | Occult HBV infection among a cohort of Nigerian adults |
| title_full | Occult HBV infection among a cohort of Nigerian adults |
| title_fullStr | Occult HBV infection among a cohort of Nigerian adults |
| title_full_unstemmed | Occult HBV infection among a cohort of Nigerian adults |
| title_short | Occult HBV infection among a cohort of Nigerian adults |
| title_sort | occult hbv infection among a cohort of nigerian adults |
| topic | occult HBV infection HCV Nigerians |
| url | https://jidc.org/index.php/journal/article/view/415 |
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