Extracutaneous Manifestation of Ulcerative Colitis: Pyoderma Gangrenosum, A Case Report
Pyoderma gangrenosum (PG) is a rare, ulcerative skin condition often associated with systemic diseases such as inflammatory bowel disease (IBD), including ulcerative colitis (UC). This case report describes a 79-year-old male patient with a history of ulcerative colitis who presented with incre...
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| Format: | Article |
| Language: | English |
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Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)
2025-03-01
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| Series: | Nepal Journal of Dermatology, Venereology & Leprology |
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| Online Access: | https://www.nepjol.info/index.php/NJDVL/article/view/69176 |
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| author | Rohan Sapkota Eliz Aryal Prashanna Raj Shrestha Jyoti Bhari Sunny Shrestha |
| author_facet | Rohan Sapkota Eliz Aryal Prashanna Raj Shrestha Jyoti Bhari Sunny Shrestha |
| author_sort | Rohan Sapkota |
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Pyoderma gangrenosum (PG) is a rare, ulcerative skin condition often associated with systemic diseases such as inflammatory bowel disease (IBD), including ulcerative colitis (UC). This case report describes a 79-year-old male patient with a history of ulcerative colitis who presented with increased passages of blood-mixed stools and a solitary ulcer on the left lower shin following minor trauma. The ulcer, measuring 10 cm by 4 cm, exhibited a violaceous border with purulent necrotic tissue. Histopathological examination revealed neutrophilic exudate, dense inflammatory cell infiltrate, perivascular neutrophilic infiltration, extravasated red blood cells, congested blood vessels, and hemosiderin-laden macrophages. The clinical presentation, along with the biopsy findings, confirmed the diagnosis of PG associated with UC. The patient was managed with systemic corticosteroids and antineutrophilic therapy, emphasizing the importance of early diagnosis and treatment to prevent disease progression. This case underscores the need for vigilance in identifying PG in patients with IBD, as prompt intervention can significantly improve outcomes.
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| format | Article |
| id | doaj-art-cd27dde4bef64469b504f5dc23a9df3c |
| institution | Kabale University |
| issn | 2091-0231 2091-167X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) |
| record_format | Article |
| series | Nepal Journal of Dermatology, Venereology & Leprology |
| spelling | doaj-art-cd27dde4bef64469b504f5dc23a9df3c2025-08-23T10:03:29ZengSociety of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)Nepal Journal of Dermatology, Venereology & Leprology2091-02312091-167X2025-03-0123110.3126/njdvl.v23i1.69176Extracutaneous Manifestation of Ulcerative Colitis: Pyoderma Gangrenosum, A Case ReportRohan Sapkota0https://orcid.org/0009-0009-4604-0757Eliz Aryal1Prashanna Raj Shrestha2Jyoti Bhari3Sunny Shrestha4Kathmandu Medical College, Sinamangal, Kathmandu, NepalKathmandu Medical College, Sinamangal, Kathmandu, NepalKathmandu Medical College, Sinamangal, Kathmandu, Nepal Kathmandu Medical College, Sinamangal, Kathmandu, NepalKathmandu Medical College, Sinamangal, Kathmandu, Nepal Pyoderma gangrenosum (PG) is a rare, ulcerative skin condition often associated with systemic diseases such as inflammatory bowel disease (IBD), including ulcerative colitis (UC). This case report describes a 79-year-old male patient with a history of ulcerative colitis who presented with increased passages of blood-mixed stools and a solitary ulcer on the left lower shin following minor trauma. The ulcer, measuring 10 cm by 4 cm, exhibited a violaceous border with purulent necrotic tissue. Histopathological examination revealed neutrophilic exudate, dense inflammatory cell infiltrate, perivascular neutrophilic infiltration, extravasated red blood cells, congested blood vessels, and hemosiderin-laden macrophages. The clinical presentation, along with the biopsy findings, confirmed the diagnosis of PG associated with UC. The patient was managed with systemic corticosteroids and antineutrophilic therapy, emphasizing the importance of early diagnosis and treatment to prevent disease progression. This case underscores the need for vigilance in identifying PG in patients with IBD, as prompt intervention can significantly improve outcomes. https://www.nepjol.info/index.php/NJDVL/article/view/69176ExtracutaneousInflammatory Bowel DiseaseNeutrophilic dermatosesPyoderma gangrenosum |
| spellingShingle | Rohan Sapkota Eliz Aryal Prashanna Raj Shrestha Jyoti Bhari Sunny Shrestha Extracutaneous Manifestation of Ulcerative Colitis: Pyoderma Gangrenosum, A Case Report Nepal Journal of Dermatology, Venereology & Leprology Extracutaneous Inflammatory Bowel Disease Neutrophilic dermatoses Pyoderma gangrenosum |
| title | Extracutaneous Manifestation of Ulcerative Colitis: Pyoderma Gangrenosum, A Case Report |
| title_full | Extracutaneous Manifestation of Ulcerative Colitis: Pyoderma Gangrenosum, A Case Report |
| title_fullStr | Extracutaneous Manifestation of Ulcerative Colitis: Pyoderma Gangrenosum, A Case Report |
| title_full_unstemmed | Extracutaneous Manifestation of Ulcerative Colitis: Pyoderma Gangrenosum, A Case Report |
| title_short | Extracutaneous Manifestation of Ulcerative Colitis: Pyoderma Gangrenosum, A Case Report |
| title_sort | extracutaneous manifestation of ulcerative colitis pyoderma gangrenosum a case report |
| topic | Extracutaneous Inflammatory Bowel Disease Neutrophilic dermatoses Pyoderma gangrenosum |
| url | https://www.nepjol.info/index.php/NJDVL/article/view/69176 |
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