Mechanism and therapeutic targets of circulating immune cells in diabetic retinopathy
Diabetic retinopathy (DR) continues to be the leading cause of preventable vision loss among working-aged adults, marked by immune dysregulation within the retinal microenvironment. Typically, the retina is considered as an immune-privileged organ, where circulating immune cells are restricted from...
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Elsevier
2024-12-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S104366182400450X |
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| author | Bowen Zhao Yin Zhao Xufang Sun |
| author_facet | Bowen Zhao Yin Zhao Xufang Sun |
| author_sort | Bowen Zhao |
| collection | DOAJ |
| description | Diabetic retinopathy (DR) continues to be the leading cause of preventable vision loss among working-aged adults, marked by immune dysregulation within the retinal microenvironment. Typically, the retina is considered as an immune-privileged organ, where circulating immune cells are restricted from entry under normal conditions. However, during the progression of DR, this immune privilege is compromised as circulating immune cells breach the barrier and infiltrate the retina. Increasing evidence suggests that vascular and neuronal degeneration in DR is largely driven by the infiltration of immune cells, particularly neutrophils, monocyte-derived macrophages, and lymphocytes. This review delves into the mechanisms and therapeutic targets associated with these immune cell populations in DR, offering a promising and innovative approach to managing the disease. |
| format | Article |
| id | doaj-art-cd27b004b8ea4e079578f46f6f9549ef |
| institution | OA Journals |
| issn | 1096-1186 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-cd27b004b8ea4e079578f46f6f9549ef2025-08-20T02:37:03ZengElsevierPharmacological Research1096-11862024-12-0121010750510.1016/j.phrs.2024.107505Mechanism and therapeutic targets of circulating immune cells in diabetic retinopathyBowen Zhao0Yin Zhao1Xufang Sun2Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaCorresponding authors.; Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaCorresponding authors.; Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDiabetic retinopathy (DR) continues to be the leading cause of preventable vision loss among working-aged adults, marked by immune dysregulation within the retinal microenvironment. Typically, the retina is considered as an immune-privileged organ, where circulating immune cells are restricted from entry under normal conditions. However, during the progression of DR, this immune privilege is compromised as circulating immune cells breach the barrier and infiltrate the retina. Increasing evidence suggests that vascular and neuronal degeneration in DR is largely driven by the infiltration of immune cells, particularly neutrophils, monocyte-derived macrophages, and lymphocytes. This review delves into the mechanisms and therapeutic targets associated with these immune cell populations in DR, offering a promising and innovative approach to managing the disease.http://www.sciencedirect.com/science/article/pii/S104366182400450XDiabetic retinopathyCirculating immune cells |
| spellingShingle | Bowen Zhao Yin Zhao Xufang Sun Mechanism and therapeutic targets of circulating immune cells in diabetic retinopathy Pharmacological Research Diabetic retinopathy Circulating immune cells |
| title | Mechanism and therapeutic targets of circulating immune cells in diabetic retinopathy |
| title_full | Mechanism and therapeutic targets of circulating immune cells in diabetic retinopathy |
| title_fullStr | Mechanism and therapeutic targets of circulating immune cells in diabetic retinopathy |
| title_full_unstemmed | Mechanism and therapeutic targets of circulating immune cells in diabetic retinopathy |
| title_short | Mechanism and therapeutic targets of circulating immune cells in diabetic retinopathy |
| title_sort | mechanism and therapeutic targets of circulating immune cells in diabetic retinopathy |
| topic | Diabetic retinopathy Circulating immune cells |
| url | http://www.sciencedirect.com/science/article/pii/S104366182400450X |
| work_keys_str_mv | AT bowenzhao mechanismandtherapeutictargetsofcirculatingimmunecellsindiabeticretinopathy AT yinzhao mechanismandtherapeutictargetsofcirculatingimmunecellsindiabeticretinopathy AT xufangsun mechanismandtherapeutictargetsofcirculatingimmunecellsindiabeticretinopathy |