Patient Characteristics in Persistent Pulmonary Hypertension of the Newborn
Objective. To assess the impact of PPHN on mortality, morbidity, and behavioural skills. Methods. A retrospective observational study of 143 newborns with PPHN, over an 11-year period, using objective health-status data from medical records and family doctors, and subjective health status data from...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/858154 |
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| author | M. T. R. Roofthooft A. Elema K. A. Bergman R. M. F. Berger |
| author_facet | M. T. R. Roofthooft A. Elema K. A. Bergman R. M. F. Berger |
| author_sort | M. T. R. Roofthooft |
| collection | DOAJ |
| description | Objective. To assess the impact of PPHN on mortality, morbidity, and behavioural skills. Methods. A retrospective observational study of 143 newborns with PPHN, over an 11-year period, using objective health-status data from medical records and family doctors, and subjective health status data from a standardized Child Behaviour Checklist. Results. The majority of patients were males, treated with inhaled nitric oxide had maladaptation/maldevelopment as pathophysiological mechanism and a gestational age >37 weeks. In term newborns, types of pathophysiological mechanism (𝑃<.001) and Oxygen Index (𝑃=.02) were independent predicting risk factors for PPHN-related mortality. Analysis of preexisting disease and outcome categories in term newborns showed only a significant correlation between the use of iNO and respiratory complaints (𝑃=.03), not confirmed by multivariate analysis and regression analysis. Conclusions. PPHN is a serious, often fatal condition. The incidence of PPHN in preterm newborns is high. In term survivors, PPHN had no additional role in morbidity/outcome. |
| format | Article |
| id | doaj-art-cd2441d0a3f64ffe931360169d50113a |
| institution | OA Journals |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-cd2441d0a3f64ffe931360169d50113a2025-08-20T02:19:53ZengWileyPulmonary Medicine2090-18362090-18442011-01-01201110.1155/2011/858154858154Patient Characteristics in Persistent Pulmonary Hypertension of the NewbornM. T. R. Roofthooft0A. Elema1K. A. Bergman2R. M. F. Berger3Department of Paediatric Cardiology, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The NetherlandsDepartment of Paediatric Cardiology, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The NetherlandsDepartment of Neonatology, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The NetherlandsDepartment of Paediatric Cardiology, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The NetherlandsObjective. To assess the impact of PPHN on mortality, morbidity, and behavioural skills. Methods. A retrospective observational study of 143 newborns with PPHN, over an 11-year period, using objective health-status data from medical records and family doctors, and subjective health status data from a standardized Child Behaviour Checklist. Results. The majority of patients were males, treated with inhaled nitric oxide had maladaptation/maldevelopment as pathophysiological mechanism and a gestational age >37 weeks. In term newborns, types of pathophysiological mechanism (𝑃<.001) and Oxygen Index (𝑃=.02) were independent predicting risk factors for PPHN-related mortality. Analysis of preexisting disease and outcome categories in term newborns showed only a significant correlation between the use of iNO and respiratory complaints (𝑃=.03), not confirmed by multivariate analysis and regression analysis. Conclusions. PPHN is a serious, often fatal condition. The incidence of PPHN in preterm newborns is high. In term survivors, PPHN had no additional role in morbidity/outcome.http://dx.doi.org/10.1155/2011/858154 |
| spellingShingle | M. T. R. Roofthooft A. Elema K. A. Bergman R. M. F. Berger Patient Characteristics in Persistent Pulmonary Hypertension of the Newborn Pulmonary Medicine |
| title | Patient Characteristics in Persistent Pulmonary Hypertension of the Newborn |
| title_full | Patient Characteristics in Persistent Pulmonary Hypertension of the Newborn |
| title_fullStr | Patient Characteristics in Persistent Pulmonary Hypertension of the Newborn |
| title_full_unstemmed | Patient Characteristics in Persistent Pulmonary Hypertension of the Newborn |
| title_short | Patient Characteristics in Persistent Pulmonary Hypertension of the Newborn |
| title_sort | patient characteristics in persistent pulmonary hypertension of the newborn |
| url | http://dx.doi.org/10.1155/2011/858154 |
| work_keys_str_mv | AT mtrroofthooft patientcharacteristicsinpersistentpulmonaryhypertensionofthenewborn AT aelema patientcharacteristicsinpersistentpulmonaryhypertensionofthenewborn AT kabergman patientcharacteristicsinpersistentpulmonaryhypertensionofthenewborn AT rmfberger patientcharacteristicsinpersistentpulmonaryhypertensionofthenewborn |