Genetic polymorphisms as predictors of the response of hepatocellular carcinoma patients to doxorubicin chemotherapy: a genome-wide association study

Genetic polymorphisms as predictors of the response of hepatocellular carcinoma patients to doxorubicin chemotherapy: a genome-wide association study

BackgroundHepatocellular carcinoma (HCC), a leading cause of cancer-related mortality, is commonly treated with doxorubicin (DOX). However, its effectiveness varies significantly among patients.AimThe present study aimed to identify potential genetic variants affecting the response of HCC patients t...

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Bibliographic Details
Main Authors: Sireen Abdul Rahim Shilbayeh, Naglaa F. Khedr, Mohammad A. Alshabeeb, Abdulmonem Ali Alsaleh, Abdalrhman Hamdan Alanizi, Omnia A. Abd El-Baset, Rehab H. Werida
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
genome-wide association study
hepatocellular carcinoma
doxorubicin
transarterial chemoembolization
array genotyping
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1604473/full
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