Chronic Granulomatous Aspergillus Synovitis: A Case Report
Aspergillus can cause invasive disease of various organs especially in patients with weakened immune systems. Aspergillus synovitis and arthritis are uncommon types of involvement due to this infection. Approches to fungal osteoarticular infections are based on only case reports. This paper presents...
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PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1885 |
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| author | Aylin Canbolat Ayhan |
| author_facet | Aylin Canbolat Ayhan |
| author_sort | Aylin Canbolat Ayhan |
| collection | DOAJ |
| description | Aspergillus can cause invasive disease of various organs especially in patients with weakened immune systems. Aspergillus synovitis and arthritis are uncommon types of involvement due to this infection. Approches to fungal osteoarticular infections are based on only case reports. This paper presents a rare case of chronic granulomatous Aspergillus synovitis in an immunocompromised 5-year old girl who was treated for acute lymphoblastic leukemia.
Introduction: Aspergillosis is one of the most serious infections for immunosuppressed patients which is caused by a fungus called Aspergillus. Hematological malignancy, prolonged neutropenia and use of broad spectrum antibacterials are some of the risk factors for invasive Aspergillus infections [1,2]. Presence of an underlying neutropenia due to chemotherapy correlates with higher mortality rates in Aspergillus infections. In a study reported by Pagano the incidence of proven or probable invasive aspergillosis among acute leukemia patients was 4.7% and attributable mortality rate (AMR) was 48% [3]. In another study the incidence was reported as 6.1% and AMR as 38.5% [4]. In Nosari’s prospective study attributable mortality for aspergillosis was 17.3% and this study supported the idea that mortality rates due to fungal infections have fallen over recent years [5]. Prompt recognition, application of a correct and diagnostic examination with early initiation of efficacious antifungal agents have diminished the incidence to 12.7% and mortality rates to13% among patients with leukemia [6]. Herein, we report a case of chronic granulomatous Aspergillus synovitis in a leukemic child which was treated successfully. |
| format | Article |
| id | doaj-art-cd1d8bc5492148f2b1898eafb472bee5 |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-cd1d8bc5492148f2b1898eafb472bee52025-08-20T02:08:32ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011Chronic Granulomatous Aspergillus Synovitis: A Case ReportAylin Canbolat AyhanAspergillus can cause invasive disease of various organs especially in patients with weakened immune systems. Aspergillus synovitis and arthritis are uncommon types of involvement due to this infection. Approches to fungal osteoarticular infections are based on only case reports. This paper presents a rare case of chronic granulomatous Aspergillus synovitis in an immunocompromised 5-year old girl who was treated for acute lymphoblastic leukemia. Introduction: Aspergillosis is one of the most serious infections for immunosuppressed patients which is caused by a fungus called Aspergillus. Hematological malignancy, prolonged neutropenia and use of broad spectrum antibacterials are some of the risk factors for invasive Aspergillus infections [1,2]. Presence of an underlying neutropenia due to chemotherapy correlates with higher mortality rates in Aspergillus infections. In a study reported by Pagano the incidence of proven or probable invasive aspergillosis among acute leukemia patients was 4.7% and attributable mortality rate (AMR) was 48% [3]. In another study the incidence was reported as 6.1% and AMR as 38.5% [4]. In Nosari’s prospective study attributable mortality for aspergillosis was 17.3% and this study supported the idea that mortality rates due to fungal infections have fallen over recent years [5]. Prompt recognition, application of a correct and diagnostic examination with early initiation of efficacious antifungal agents have diminished the incidence to 12.7% and mortality rates to13% among patients with leukemia [6]. Herein, we report a case of chronic granulomatous Aspergillus synovitis in a leukemic child which was treated successfully.https://mjhid.org/index.php/mjhid/article/view/1885 |
| spellingShingle | Aylin Canbolat Ayhan Chronic Granulomatous Aspergillus Synovitis: A Case Report Mediterranean Journal of Hematology and Infectious Diseases |
| title | Chronic Granulomatous Aspergillus Synovitis: A Case Report |
| title_full | Chronic Granulomatous Aspergillus Synovitis: A Case Report |
| title_fullStr | Chronic Granulomatous Aspergillus Synovitis: A Case Report |
| title_full_unstemmed | Chronic Granulomatous Aspergillus Synovitis: A Case Report |
| title_short | Chronic Granulomatous Aspergillus Synovitis: A Case Report |
| title_sort | chronic granulomatous aspergillus synovitis a case report |
| url | https://mjhid.org/index.php/mjhid/article/view/1885 |
| work_keys_str_mv | AT aylincanbolatayhan chronicgranulomatousaspergillussynovitisacasereport |