Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms
Rats(r) with secondary hyperparathyroidism were studied to define the relationship between vitamin D metabolites and rPTH levels measured by 3 different rat ELISAs. Controls and renal failure (RF) rats were on a normal diet, while 2 groups on a low-calcium (-Ca)...
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Wiley
2011-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2011/469783 |
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| author | Pierre D'Amour Louise Rousseau Stephen Hornyak Zan Yang Tom Cantor |
| author_facet | Pierre D'Amour Louise Rousseau Stephen Hornyak Zan Yang Tom Cantor |
| author_sort | Pierre D'Amour |
| collection | DOAJ |
| description | Rats(r) with secondary hyperparathyroidism were studied to define the relationship between vitamin
D metabolites and rPTH levels measured by 3 different rat ELISAs. Controls and renal failure (RF) rats were on
a normal diet, while 2 groups on a low-calcium (-Ca) or a vitamin D-deficient (-D) diet. RF was induced surgically. Mild RF rats
had normal calcium and 25(OH)D but reduced 1,25(OH)2D levels (P<.001) with a 2.5-fold increased in rPTH (P<.001). Severe RF rats and those on a -Ca or -D diet had reduced calcium (P<.01) and 25(OH)D levels (P<.05), with rPTH increased by 2 (-Ca diet; P<.05), 4 (-D diet; P<.001), and 20-folds (RF; P<.001) while 1,25(OH)2D was high (-Ca diet: P<.001) or low (-D diet, RF: P<.001). 25(OH)D and 1,25(OH)2D were positively and negatively related on the -Ca and -D diets, respectively.
rPTH molecular forms behaved as expected in RF and on -Ca diet, but not on -D diet with more C-rPTH fragments
when less were expected. This may be related to the short-time course of this study compared to prior studies. |
| format | Article |
| id | doaj-art-cd1d7682837e4e93a57e541f11e59b1e |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-cd1d7682837e4e93a57e541f11e59b1e2025-08-20T02:19:53ZengWileyInternational Journal of Endocrinology1687-83371687-83452011-01-01201110.1155/2011/469783469783Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular FormsPierre D'Amour0Louise Rousseau1Stephen Hornyak2Zan Yang3Tom Cantor4Centre de Recherche, Centre Hospitalier de l'Université de Montréal (CRCHUM), Hôpital Saint-Luc Département de Médecine, Université de Montréal, Montréal, QC, H2X 1P1, CanadaCentre de Recherche, Centre Hospitalier de l'Université de Montréal (CRCHUM), Hôpital Saint-Luc Département de Médecine, Université de Montréal, Montréal, QC, H2X 1P1, CanadaScantibodies Laboratory Inc., Santee, CA 92071, USAScantibodies Laboratory Inc., Santee, CA 92071, USAScantibodies Laboratory Inc., Santee, CA 92071, USARats(r) with secondary hyperparathyroidism were studied to define the relationship between vitamin D metabolites and rPTH levels measured by 3 different rat ELISAs. Controls and renal failure (RF) rats were on a normal diet, while 2 groups on a low-calcium (-Ca) or a vitamin D-deficient (-D) diet. RF was induced surgically. Mild RF rats had normal calcium and 25(OH)D but reduced 1,25(OH)2D levels (P<.001) with a 2.5-fold increased in rPTH (P<.001). Severe RF rats and those on a -Ca or -D diet had reduced calcium (P<.01) and 25(OH)D levels (P<.05), with rPTH increased by 2 (-Ca diet; P<.05), 4 (-D diet; P<.001), and 20-folds (RF; P<.001) while 1,25(OH)2D was high (-Ca diet: P<.001) or low (-D diet, RF: P<.001). 25(OH)D and 1,25(OH)2D were positively and negatively related on the -Ca and -D diets, respectively. rPTH molecular forms behaved as expected in RF and on -Ca diet, but not on -D diet with more C-rPTH fragments when less were expected. This may be related to the short-time course of this study compared to prior studies.http://dx.doi.org/10.1155/2011/469783 |
| spellingShingle | Pierre D'Amour Louise Rousseau Stephen Hornyak Zan Yang Tom Cantor Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms International Journal of Endocrinology |
| title | Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms |
| title_full | Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms |
| title_fullStr | Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms |
| title_full_unstemmed | Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms |
| title_short | Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms |
| title_sort | influence of secondary hyperparathyroidism induced by low dietary calcium vitamin d deficiency and renal failure on circulating rat pth molecular forms |
| url | http://dx.doi.org/10.1155/2011/469783 |
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