The Contribution of the Skin Microbiome to Psoriasis Pathogenesis and Its Implications for Therapeutic Strategies
Psoriasis is a common chronic inflammatory skin disease, associated with significant morbidity and a considerable negative impact on the patients’ quality of life. The complex pathogenesis of psoriasis is still incompletely understood. Genetic predisposition, environmental factors like smoking, alco...
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MDPI AG
2024-10-01
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| author | Diana Sabina Radaschin Alin Tatu Alina Viorica Iancu Cristina Beiu Liliana Gabriela Popa |
| author_facet | Diana Sabina Radaschin Alin Tatu Alina Viorica Iancu Cristina Beiu Liliana Gabriela Popa |
| author_sort | Diana Sabina Radaschin |
| collection | DOAJ |
| description | Psoriasis is a common chronic inflammatory skin disease, associated with significant morbidity and a considerable negative impact on the patients’ quality of life. The complex pathogenesis of psoriasis is still incompletely understood. Genetic predisposition, environmental factors like smoking, alcohol consumption, psychological stress, consumption of certain drugs, and mechanical trauma, as well as specific immune dysfunctions, contribute to the onset of the disease. Mounting evidence indicate that skin dysbiosis plays a significant role in the development and exacerbation of psoriasis through loss of immune tolerance to commensal skin flora, an altered balance between Tregs and effector cells, and an excessive Th1 and Th17 polarization. While the implications of skin dysbiosis in psoriasis pathogenesis are only starting to be revealed, the progress in the characterization of the skin microbiome changes in psoriasis patients has opened a whole new avenue of research focusing on the modulation of the skin microbiome as an adjuvant treatment for psoriasis and as part of a long-term plan to prevent disease flares. The skin microbiome may also represent a valuable predictive marker of treatment response and may aid in the selection of the optimal personalized treatment. We present the current knowledge on the skin microbiome changes in psoriasis and the results of the studies that investigated the efficacy of the different skin microbiome modulation strategies in the management of psoriasis, and discuss the complex interaction between the host and skin commensal flora. |
| format | Article |
| id | doaj-art-cd1553d834cd420c8f6b3305ef16ae68 |
| institution | OA Journals |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-cd1553d834cd420c8f6b3305ef16ae682025-08-20T02:10:56ZengMDPI AGMedicina1010-660X1648-91442024-10-016010161910.3390/medicina60101619The Contribution of the Skin Microbiome to Psoriasis Pathogenesis and Its Implications for Therapeutic StrategiesDiana Sabina Radaschin0Alin Tatu1Alina Viorica Iancu2Cristina Beiu3Liliana Gabriela Popa4Department of Clinical Medical, Faculty of Medicine and Pharmacy, “Saint Parascheva” Infectious Disease Clinical Hospital, Multidisciplinary Integrated Centre of Dermatological Interface Research Centre (MICDIR), “Dunarea de Jos” University of Galati, 800008 Galati, RomaniaDepartment of Clinical Medical, Faculty of Medicine and Pharmacy, “Saint Parascheva” Infectious Disease Clinical Hospital, Multidisciplinary Integrated Centre of Dermatological Interface Research Centre (MICDIR), “Dunarea de Jos” University of Galati, 800008 Galati, RomaniaDepartment of Morphological and Functional Sciences, “Dunarea de Jos” University of Galati, 800008 Galati, RomaniaDepartment of Oncologic Dermatology, Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Oncologic Dermatology, Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaPsoriasis is a common chronic inflammatory skin disease, associated with significant morbidity and a considerable negative impact on the patients’ quality of life. The complex pathogenesis of psoriasis is still incompletely understood. Genetic predisposition, environmental factors like smoking, alcohol consumption, psychological stress, consumption of certain drugs, and mechanical trauma, as well as specific immune dysfunctions, contribute to the onset of the disease. Mounting evidence indicate that skin dysbiosis plays a significant role in the development and exacerbation of psoriasis through loss of immune tolerance to commensal skin flora, an altered balance between Tregs and effector cells, and an excessive Th1 and Th17 polarization. While the implications of skin dysbiosis in psoriasis pathogenesis are only starting to be revealed, the progress in the characterization of the skin microbiome changes in psoriasis patients has opened a whole new avenue of research focusing on the modulation of the skin microbiome as an adjuvant treatment for psoriasis and as part of a long-term plan to prevent disease flares. The skin microbiome may also represent a valuable predictive marker of treatment response and may aid in the selection of the optimal personalized treatment. We present the current knowledge on the skin microbiome changes in psoriasis and the results of the studies that investigated the efficacy of the different skin microbiome modulation strategies in the management of psoriasis, and discuss the complex interaction between the host and skin commensal flora.https://www.mdpi.com/1648-9144/60/10/1619skin microbiomepsoriasischronic inflammatory skin diseaseprobioticsprebiotics |
| spellingShingle | Diana Sabina Radaschin Alin Tatu Alina Viorica Iancu Cristina Beiu Liliana Gabriela Popa The Contribution of the Skin Microbiome to Psoriasis Pathogenesis and Its Implications for Therapeutic Strategies Medicina skin microbiome psoriasis chronic inflammatory skin disease probiotics prebiotics |
| title | The Contribution of the Skin Microbiome to Psoriasis Pathogenesis and Its Implications for Therapeutic Strategies |
| title_full | The Contribution of the Skin Microbiome to Psoriasis Pathogenesis and Its Implications for Therapeutic Strategies |
| title_fullStr | The Contribution of the Skin Microbiome to Psoriasis Pathogenesis and Its Implications for Therapeutic Strategies |
| title_full_unstemmed | The Contribution of the Skin Microbiome to Psoriasis Pathogenesis and Its Implications for Therapeutic Strategies |
| title_short | The Contribution of the Skin Microbiome to Psoriasis Pathogenesis and Its Implications for Therapeutic Strategies |
| title_sort | contribution of the skin microbiome to psoriasis pathogenesis and its implications for therapeutic strategies |
| topic | skin microbiome psoriasis chronic inflammatory skin disease probiotics prebiotics |
| url | https://www.mdpi.com/1648-9144/60/10/1619 |
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