The Senegalese and Brazilian strains of Schistosoma mansoni exhibit high compatibility with Biomphalaria pfeifferi and Biomphalaria glabrata

Abstract Background Intestinal schistosomiasis, caused by Schistosoma mansoni, is endemic in both Africa and South America. In Senegal and Brazil, S. mansoni is transmitted by Biomphalaria pfeifferi and Biomphalaria glabrata, respectively. With increasing human migration from Senegal to the Americas...

Full description

Saved in:
Bibliographic Details
Main Authors: Mbéré Sarr, Malick Diop, Abdoulaye Jacque Bakhoum, Souleymane Doucoure, Doudou Sow, Cheikh Tidiane Bâ, Cheikh Sokhna, Jérôme Boissier, Bruno Senghor
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Parasites & Vectors
Subjects:
Online Access:https://doi.org/10.1186/s13071-025-06918-5
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1849333570259124224
author Mbéré Sarr
Malick Diop
Abdoulaye Jacque Bakhoum
Souleymane Doucoure
Doudou Sow
Cheikh Tidiane Bâ
Cheikh Sokhna
Jérôme Boissier
Bruno Senghor
author_facet Mbéré Sarr
Malick Diop
Abdoulaye Jacque Bakhoum
Souleymane Doucoure
Doudou Sow
Cheikh Tidiane Bâ
Cheikh Sokhna
Jérôme Boissier
Bruno Senghor
author_sort Mbéré Sarr
collection DOAJ
description Abstract Background Intestinal schistosomiasis, caused by Schistosoma mansoni, is endemic in both Africa and South America. In Senegal and Brazil, S. mansoni is transmitted by Biomphalaria pfeifferi and Biomphalaria glabrata, respectively. With increasing human migration from Senegal to the Americas, there is a potential risk of transferring parasite strains across continents. Understanding the compatibility between Schistosoma species and strains, and snail hosts is therefore essential. This study investigated the compatibility of two S. mansoni strains from Senegal (SmSEN) and Brazil (SmBRA) with both B. pfeifferi (BpSEN) and B. glabrata (BgBRA) originating from Senegal and Brazil, respectively. Methods Four infection combinations were performed: (1) SmSEN + BpSEN (2) SmSEN + BgBRA (3) SmBRA + BgBRA, and (4) SmBRA + BpSEN. A minimum of 72 snails were individually exposed to five miracidia per combination. Results The data show high compatibility between Brazilian and Senegalese S. mansoni with B. pfeifferi (92.4% and 77.3%, respectively). In contrast, both strains showed a low compatibility with B. glabrata, with rates of 67.3 and 48% for the Brazilian and Senegalese S. mansoni, respectively. Conclusions The high compatibility between S. mansoni and Biomphalaria species from Senegal and Brazil highlights the adaptability of S. mansoni to infect different Biomphalaria species across geographically distinct regions. These findings emphasize the importance of monitoring areas at risk of schistosomiasis emergence, particularly in the context of human migration and the invasive spread of Biomphalaria species into novel environments. Graphical abstract
format Article
id doaj-art-cd139ece0f7d46db9c3fdb445148c051
institution Kabale University
issn 1756-3305
language English
publishDate 2025-07-01
publisher BMC
record_format Article
series Parasites & Vectors
spelling doaj-art-cd139ece0f7d46db9c3fdb445148c0512025-08-20T03:45:48ZengBMCParasites & Vectors1756-33052025-07-011811710.1186/s13071-025-06918-5The Senegalese and Brazilian strains of Schistosoma mansoni exhibit high compatibility with Biomphalaria pfeifferi and Biomphalaria glabrataMbéré Sarr0Malick Diop1Abdoulaye Jacque Bakhoum2Souleymane Doucoure3Doudou Sow4Cheikh Tidiane Bâ5Cheikh Sokhna6Jérôme Boissier7Bruno Senghor8MINES, UCAD-IRD International CampusMINES, UCAD-IRD International CampusDepartment of Animal Biology, Cheikh Anta Diop University of DakarMINES, UCAD-IRD International CampusDepartment of Parasitology-Mycology, Health Sciences Training & Research Unit, University Gaston BergerDepartment of Animal Biology, Cheikh Anta Diop University of DakarMINES, UCAD-IRD International CampusHost-Pathogen-Environment Interactions (IHPE) Laboratory, CNRS, IFREMER, University of Montpellier, University of Perpignan Via DomitiaMINES, UCAD-IRD International CampusAbstract Background Intestinal schistosomiasis, caused by Schistosoma mansoni, is endemic in both Africa and South America. In Senegal and Brazil, S. mansoni is transmitted by Biomphalaria pfeifferi and Biomphalaria glabrata, respectively. With increasing human migration from Senegal to the Americas, there is a potential risk of transferring parasite strains across continents. Understanding the compatibility between Schistosoma species and strains, and snail hosts is therefore essential. This study investigated the compatibility of two S. mansoni strains from Senegal (SmSEN) and Brazil (SmBRA) with both B. pfeifferi (BpSEN) and B. glabrata (BgBRA) originating from Senegal and Brazil, respectively. Methods Four infection combinations were performed: (1) SmSEN + BpSEN (2) SmSEN + BgBRA (3) SmBRA + BgBRA, and (4) SmBRA + BpSEN. A minimum of 72 snails were individually exposed to five miracidia per combination. Results The data show high compatibility between Brazilian and Senegalese S. mansoni with B. pfeifferi (92.4% and 77.3%, respectively). In contrast, both strains showed a low compatibility with B. glabrata, with rates of 67.3 and 48% for the Brazilian and Senegalese S. mansoni, respectively. Conclusions The high compatibility between S. mansoni and Biomphalaria species from Senegal and Brazil highlights the adaptability of S. mansoni to infect different Biomphalaria species across geographically distinct regions. These findings emphasize the importance of monitoring areas at risk of schistosomiasis emergence, particularly in the context of human migration and the invasive spread of Biomphalaria species into novel environments. Graphical abstracthttps://doi.org/10.1186/s13071-025-06918-5Schistosoma mansoniBiomphalaria glabrataBiomphalaria pfeifferiSenegalBrazilCompatibility
spellingShingle Mbéré Sarr
Malick Diop
Abdoulaye Jacque Bakhoum
Souleymane Doucoure
Doudou Sow
Cheikh Tidiane Bâ
Cheikh Sokhna
Jérôme Boissier
Bruno Senghor
The Senegalese and Brazilian strains of Schistosoma mansoni exhibit high compatibility with Biomphalaria pfeifferi and Biomphalaria glabrata
Parasites & Vectors
Schistosoma mansoni
Biomphalaria glabrata
Biomphalaria pfeifferi
Senegal
Brazil
Compatibility
title The Senegalese and Brazilian strains of Schistosoma mansoni exhibit high compatibility with Biomphalaria pfeifferi and Biomphalaria glabrata
title_full The Senegalese and Brazilian strains of Schistosoma mansoni exhibit high compatibility with Biomphalaria pfeifferi and Biomphalaria glabrata
title_fullStr The Senegalese and Brazilian strains of Schistosoma mansoni exhibit high compatibility with Biomphalaria pfeifferi and Biomphalaria glabrata
title_full_unstemmed The Senegalese and Brazilian strains of Schistosoma mansoni exhibit high compatibility with Biomphalaria pfeifferi and Biomphalaria glabrata
title_short The Senegalese and Brazilian strains of Schistosoma mansoni exhibit high compatibility with Biomphalaria pfeifferi and Biomphalaria glabrata
title_sort senegalese and brazilian strains of schistosoma mansoni exhibit high compatibility with biomphalaria pfeifferi and biomphalaria glabrata
topic Schistosoma mansoni
Biomphalaria glabrata
Biomphalaria pfeifferi
Senegal
Brazil
Compatibility
url https://doi.org/10.1186/s13071-025-06918-5
work_keys_str_mv AT mberesarr thesenegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT malickdiop thesenegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT abdoulayejacquebakhoum thesenegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT souleymanedoucoure thesenegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT doudousow thesenegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT cheikhtidianeba thesenegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT cheikhsokhna thesenegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT jeromeboissier thesenegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT brunosenghor thesenegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT mberesarr senegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT malickdiop senegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT abdoulayejacquebakhoum senegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT souleymanedoucoure senegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT doudousow senegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT cheikhtidianeba senegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT cheikhsokhna senegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT jeromeboissier senegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata
AT brunosenghor senegaleseandbrazilianstrainsofschistosomamansoniexhibithighcompatibilitywithbiomphalariapfeifferiandbiomphalariaglabrata