The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and pulmonary function: evidence from NHANES 2007–2012
BackgroundThis research aims to explore the potential association between lung function and the ratio of non-high-density lipoprotein cholesterol (NHL) to high-density lipoprotein cholesterol (NHHR). Previous research has shown that lipid metabolism imbalance is closely linked to cardiovascular dise...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1534958/full |
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| author | Miaoyan Liu Chaofeng Gao Jinggeng Li Yibo Zhang Rui Gao Chaoting Yang Jian Zhang |
| author_facet | Miaoyan Liu Chaofeng Gao Jinggeng Li Yibo Zhang Rui Gao Chaoting Yang Jian Zhang |
| author_sort | Miaoyan Liu |
| collection | DOAJ |
| description | BackgroundThis research aims to explore the potential association between lung function and the ratio of non-high-density lipoprotein cholesterol (NHL) to high-density lipoprotein cholesterol (NHHR). Previous research has shown that lipid metabolism imbalance is closely linked to cardiovascular disease, however, there is a lack of information regarding its impact on lung function.MethodsThis research used information from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2007 to 2012, including a large-scale sample of 9,498 adults aged 20 years and older. A cross-sectional study employing multivariable regression models was aimed at examining the relevance between NHHR and indicators of lung function (FEV1, FVC, and FEV1/FVC). Adjustments were made for a wide range of confounding factors, encompassing race, gender, age, BMI, smoking status, physical activity, diabetes, alcohol consumption, and education level. Data analysis included categorizing NHHR into quartiles and using trend tests to evaluate dose–response relationships between NHHR quartiles and lung function. Sensitivity analyses were conducted by excluding participants with asthma and COPD to ensure the reliability of the results.ResultsThe results manifested a significant correlation between decreased FEV1 and FVC values and elevated NHHR, most notably within the highest quartile of NHHR (Q4), where the association was most pronounced. Additionally, trend test results indicated a significant linear negative correlation between NHHR and both FEV1 and FVC. However, the correlation between FEV1/FVC and NHHR showed a nonlinear U-shaped pattern. Suggesting differential impacts of NHHR on various lung function indicators. The findings’ robustness was shown by sensitivity analysis, which revealed that even after omitting people with asthma and COPD, the negative correlation between NHHR and FEV1 and FVC remained significant.ConclusionThis research emphasizes the significance of tracking lipid levels in evaluating respiratory health and offers early evidence in favor of NHHR as a probable biomarker for respiratory function. Further longitudinal research has occasion to prove the causal relationship between NHHR and lung function and to explore its underlying biological mechanisms. |
| format | Article |
| id | doaj-art-cd125fbbadee42b8b6d060c5503283a6 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-cd125fbbadee42b8b6d060c5503283a62025-08-20T03:41:46ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-03-011210.3389/fnut.2025.15349581534958The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and pulmonary function: evidence from NHANES 2007–2012Miaoyan Liu0Chaofeng Gao1Jinggeng Li2Yibo Zhang3Rui Gao4Chaoting Yang5Jian Zhang6Department of Respiratory Medicine, Chest Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou, ChinaDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Air Force Medical University, Xi'an, ChinaDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Air Force Medical University, Xi'an, ChinaGraduate Work Department, Xi'an Medical University, Xi'an, ChinaGraduate Work Department, Xi'an Medical University, Xi'an, ChinaDepartment of Respiratory Medicine, Chest Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, ChinaBackgroundThis research aims to explore the potential association between lung function and the ratio of non-high-density lipoprotein cholesterol (NHL) to high-density lipoprotein cholesterol (NHHR). Previous research has shown that lipid metabolism imbalance is closely linked to cardiovascular disease, however, there is a lack of information regarding its impact on lung function.MethodsThis research used information from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2007 to 2012, including a large-scale sample of 9,498 adults aged 20 years and older. A cross-sectional study employing multivariable regression models was aimed at examining the relevance between NHHR and indicators of lung function (FEV1, FVC, and FEV1/FVC). Adjustments were made for a wide range of confounding factors, encompassing race, gender, age, BMI, smoking status, physical activity, diabetes, alcohol consumption, and education level. Data analysis included categorizing NHHR into quartiles and using trend tests to evaluate dose–response relationships between NHHR quartiles and lung function. Sensitivity analyses were conducted by excluding participants with asthma and COPD to ensure the reliability of the results.ResultsThe results manifested a significant correlation between decreased FEV1 and FVC values and elevated NHHR, most notably within the highest quartile of NHHR (Q4), where the association was most pronounced. Additionally, trend test results indicated a significant linear negative correlation between NHHR and both FEV1 and FVC. However, the correlation between FEV1/FVC and NHHR showed a nonlinear U-shaped pattern. Suggesting differential impacts of NHHR on various lung function indicators. The findings’ robustness was shown by sensitivity analysis, which revealed that even after omitting people with asthma and COPD, the negative correlation between NHHR and FEV1 and FVC remained significant.ConclusionThis research emphasizes the significance of tracking lipid levels in evaluating respiratory health and offers early evidence in favor of NHHR as a probable biomarker for respiratory function. Further longitudinal research has occasion to prove the causal relationship between NHHR and lung function and to explore its underlying biological mechanisms.https://www.frontiersin.org/articles/10.3389/fnut.2025.1534958/fullNHHRpulmonary functionNHANESlipidscross-sectional research |
| spellingShingle | Miaoyan Liu Chaofeng Gao Jinggeng Li Yibo Zhang Rui Gao Chaoting Yang Jian Zhang The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and pulmonary function: evidence from NHANES 2007–2012 Frontiers in Nutrition NHHR pulmonary function NHANES lipids cross-sectional research |
| title | The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and pulmonary function: evidence from NHANES 2007–2012 |
| title_full | The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and pulmonary function: evidence from NHANES 2007–2012 |
| title_fullStr | The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and pulmonary function: evidence from NHANES 2007–2012 |
| title_full_unstemmed | The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and pulmonary function: evidence from NHANES 2007–2012 |
| title_short | The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and pulmonary function: evidence from NHANES 2007–2012 |
| title_sort | association between non high density lipoprotein cholesterol to high density lipoprotein cholesterol ratio and pulmonary function evidence from nhanes 2007 2012 |
| topic | NHHR pulmonary function NHANES lipids cross-sectional research |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1534958/full |
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