Transcatheter patent ductus arteriosus closure in very low birth weight preterm infants: early results and midterm follow-up
BackgroundAlthough transcatheter patent ductus arteriosus (PDA) closure is becoming increasingly common in very low birth weight (VLBW) preterm infants, several key issues remain controversial. These include identifying suitable patient characteristics, determining the optimal timing for PDA closure...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1650335/full |
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| author | Junhui Liu Wei Gao Zigang Liu Kun Zhao Gang Luo Shuai Gao Yi Sun Silin Pan |
| author_facet | Junhui Liu Wei Gao Zigang Liu Kun Zhao Gang Luo Shuai Gao Yi Sun Silin Pan |
| author_sort | Junhui Liu |
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| description | BackgroundAlthough transcatheter patent ductus arteriosus (PDA) closure is becoming increasingly common in very low birth weight (VLBW) preterm infants, several key issues remain controversial. These include identifying suitable patient characteristics, determining the optimal timing for PDA closure, preventing potential complications, and accurately assessing mid- and long-term outcomes. This study aims to summarize our preliminary experience in selecting appropriate patients and timing for PDA closure, and to report the early and mid-term outcomes of transcatheter PDA closure in VLBW preterm infants.MethodsThis was a single-center retrospective study. Eligible participants included preterm infants with gestational age <37 weeks and birth weight <1,500 g who underwent transcatheter PDA closure between January 2024 and January 2025 at Qingdao Women and Children's Hospital. Data on patient characteristics, procedural age, PDA closure, survival, and intraoperative or postoperative complications were collected. Outcomes were assessed immediately after the procedure, at discharge, and 6 months post-discharge.ResultsProcedures were performed in 8 VLBW preterm infants [median procedural age 23 days (range: 13–36 days), median procedural weight 1,350 g (range: 810–1,480 g), median PDA diameter 3.75 mm (range: 2.3–4.1 mm)]. The devices were Amplatzer Piccolo (n = 8). Procedures were successful in 100% and uneventful in 87.5% (7 of 8). One patient experienced mild left pulmonary artery compression intraoperatively, which resolved with device repositioning. 25% (2 of 8) patients experienced transient systemic hypertension within 24 h postoperatively, which resolved with diuretic and sedative treatment. No patients experienced ventilation or oxygenation failure, residual PDA, device malposition, or embolization. Survival to discharge was 100%. At 6-month follow-up, all patients were alive and well, without residual PDA, left pulmonary artery stenosis, and aortic coarctation.ConclusionsThe promising early and mid-term outcomes suggest that transcatheter PDA closure in VLBW preterm infants is feasible. Suitable patient characteristics, accurate PDA closure timing, and careful postoperative care are crucial determinants for procedural success. Future studies need to further expand the sample size and extend the follow-up period to evaluate the long-term efficacy and potential complications of this intervention. |
| format | Article |
| id | doaj-art-cd0dfe6326744558842e40ce97c5ffaf |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-07-01 |
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| series | Frontiers in Pediatrics |
| spelling | doaj-art-cd0dfe6326744558842e40ce97c5ffaf2025-08-20T03:34:29ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-07-011310.3389/fped.2025.16503351650335Transcatheter patent ductus arteriosus closure in very low birth weight preterm infants: early results and midterm follow-upJunhui Liu0Wei Gao1Zigang Liu2Kun Zhao3Gang Luo4Shuai Gao5Yi Sun6Silin Pan7Heart Center, Women and Children’s Hospital, Qingdao University, Qingdao, ChinaCardiology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaCardiothoracic Surgery, Baoan District Maternal and Child Health Hospital, Shenzhen, ChinaHeart Center, Northwest Women’s and Children’s Hospital, Xian, ChinaHeart Center, Women and Children’s Hospital, Qingdao University, Qingdao, ChinaHeart Center, Women and Children’s Hospital, Qingdao University, Qingdao, ChinaHeart Center, Women and Children’s Hospital, Qingdao University, Qingdao, ChinaHeart Center, Women and Children’s Hospital, Qingdao University, Qingdao, ChinaBackgroundAlthough transcatheter patent ductus arteriosus (PDA) closure is becoming increasingly common in very low birth weight (VLBW) preterm infants, several key issues remain controversial. These include identifying suitable patient characteristics, determining the optimal timing for PDA closure, preventing potential complications, and accurately assessing mid- and long-term outcomes. This study aims to summarize our preliminary experience in selecting appropriate patients and timing for PDA closure, and to report the early and mid-term outcomes of transcatheter PDA closure in VLBW preterm infants.MethodsThis was a single-center retrospective study. Eligible participants included preterm infants with gestational age <37 weeks and birth weight <1,500 g who underwent transcatheter PDA closure between January 2024 and January 2025 at Qingdao Women and Children's Hospital. Data on patient characteristics, procedural age, PDA closure, survival, and intraoperative or postoperative complications were collected. Outcomes were assessed immediately after the procedure, at discharge, and 6 months post-discharge.ResultsProcedures were performed in 8 VLBW preterm infants [median procedural age 23 days (range: 13–36 days), median procedural weight 1,350 g (range: 810–1,480 g), median PDA diameter 3.75 mm (range: 2.3–4.1 mm)]. The devices were Amplatzer Piccolo (n = 8). Procedures were successful in 100% and uneventful in 87.5% (7 of 8). One patient experienced mild left pulmonary artery compression intraoperatively, which resolved with device repositioning. 25% (2 of 8) patients experienced transient systemic hypertension within 24 h postoperatively, which resolved with diuretic and sedative treatment. No patients experienced ventilation or oxygenation failure, residual PDA, device malposition, or embolization. Survival to discharge was 100%. At 6-month follow-up, all patients were alive and well, without residual PDA, left pulmonary artery stenosis, and aortic coarctation.ConclusionsThe promising early and mid-term outcomes suggest that transcatheter PDA closure in VLBW preterm infants is feasible. Suitable patient characteristics, accurate PDA closure timing, and careful postoperative care are crucial determinants for procedural success. Future studies need to further expand the sample size and extend the follow-up period to evaluate the long-term efficacy and potential complications of this intervention.https://www.frontiersin.org/articles/10.3389/fped.2025.1650335/fulltranscatheter closurepatent ductus arteriosusvery low birth weightpreterm infantsmidterm follow-up |
| spellingShingle | Junhui Liu Wei Gao Zigang Liu Kun Zhao Gang Luo Shuai Gao Yi Sun Silin Pan Transcatheter patent ductus arteriosus closure in very low birth weight preterm infants: early results and midterm follow-up Frontiers in Pediatrics transcatheter closure patent ductus arteriosus very low birth weight preterm infants midterm follow-up |
| title | Transcatheter patent ductus arteriosus closure in very low birth weight preterm infants: early results and midterm follow-up |
| title_full | Transcatheter patent ductus arteriosus closure in very low birth weight preterm infants: early results and midterm follow-up |
| title_fullStr | Transcatheter patent ductus arteriosus closure in very low birth weight preterm infants: early results and midterm follow-up |
| title_full_unstemmed | Transcatheter patent ductus arteriosus closure in very low birth weight preterm infants: early results and midterm follow-up |
| title_short | Transcatheter patent ductus arteriosus closure in very low birth weight preterm infants: early results and midterm follow-up |
| title_sort | transcatheter patent ductus arteriosus closure in very low birth weight preterm infants early results and midterm follow up |
| topic | transcatheter closure patent ductus arteriosus very low birth weight preterm infants midterm follow-up |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1650335/full |
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