Meta-analysis of association between atmospheric ozone exposure and atherosclerotic cardiovascular disease
BackgroundAtherosclerotic cardiovascular disease (ASCVD) is a major contributor to the global burden of cardiovascular diseases. However, evidence from meta-analyses on the association between ambient ozone exposure and ASCVD risk remains relatively insufficient. ObjectiveTo explore the epidemiologi...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Editorial Committee of Journal of Environmental and Occupational Medicine
2025-06-01
|
| Series: | 环境与职业医学 |
| Subjects: | |
| Online Access: | http://www.jeom.org/article/cn/10.11836/JEOM24531 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850100560202563584 |
|---|---|
| author | Bingqian WANG Teng YANG Shuting XIE Meng TAN Guoxing LI Jing HUANG |
| author_facet | Bingqian WANG Teng YANG Shuting XIE Meng TAN Guoxing LI Jing HUANG |
| author_sort | Bingqian WANG |
| collection | DOAJ |
| description | BackgroundAtherosclerotic cardiovascular disease (ASCVD) is a major contributor to the global burden of cardiovascular diseases. However, evidence from meta-analyses on the association between ambient ozone exposure and ASCVD risk remains relatively insufficient. ObjectiveTo explore the epidemiological association between ambient ozone exposure and ASCVD, providing scientific evidence for ASCVD prevention and control from the perspective of environmental risk factor management. MethodsWe systematically searched PubMed, Web of Science, Embase, the Cochrane Library, CNKI, Wanfang Database, CBM, and VIP for published epidemiological studies on the relationship between ambient ozone exposure and ASCVD from January 2007 to December 2023. We performed quality assessment and data extraction of the included studies, and utilized meta-analysis to evaluate the effects of short-term and long-term ozone exposure on different ASCVD outcomes, including mortality and incidence of ischemic heart disease (IHD) and ischemic stroke (IS). ResultsA total of 24 studies were included based on a set of predetermined eligibility criteria. The meta-analysis results indicated that short-term ozone exposure was associated with an increased risk of ASCVD mortality and incidence. Specifically, short-term ozone exposure was significantly associated with an elevated risk of IHD mortality (combined RR=1.011, 95%CI: 1.008, 1.015; P < 0.05). Additionally, short-term ozone exposure was significantly linked to increased IS mortality (combined RR=1.005, 95%CI: 1.003, 1.008; P < 0.05) and incidence (combined RR=1.015, 95%CI: 1.003, 1.027; P < 0.05). ConclusionShort-term exposure to ambient ozone significantly elevates acute cardiovascular disease risk. However, the epidemiological association between long-term ozone exposure and ASCVD remains inconclusive. Future high-quality cohort studies with refined exposure assessment methods are warranted to elucidate the chronic cardiovascular effects of ozone exposure. |
| format | Article |
| id | doaj-art-cd0b4da84c3345e995b7cdbc980c5bc3 |
| institution | DOAJ |
| issn | 2095-9982 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Editorial Committee of Journal of Environmental and Occupational Medicine |
| record_format | Article |
| series | 环境与职业医学 |
| spelling | doaj-art-cd0b4da84c3345e995b7cdbc980c5bc32025-08-20T02:40:17ZengEditorial Committee of Journal of Environmental and Occupational Medicine环境与职业医学2095-99822025-06-0142674074710.11836/JEOM2453124531Meta-analysis of association between atmospheric ozone exposure and atherosclerotic cardiovascular diseaseBingqian WANG0Teng YANG1Shuting XIE2Meng TAN3Guoxing LI4Jing HUANG5Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, ChinaBackgroundAtherosclerotic cardiovascular disease (ASCVD) is a major contributor to the global burden of cardiovascular diseases. However, evidence from meta-analyses on the association between ambient ozone exposure and ASCVD risk remains relatively insufficient. ObjectiveTo explore the epidemiological association between ambient ozone exposure and ASCVD, providing scientific evidence for ASCVD prevention and control from the perspective of environmental risk factor management. MethodsWe systematically searched PubMed, Web of Science, Embase, the Cochrane Library, CNKI, Wanfang Database, CBM, and VIP for published epidemiological studies on the relationship between ambient ozone exposure and ASCVD from January 2007 to December 2023. We performed quality assessment and data extraction of the included studies, and utilized meta-analysis to evaluate the effects of short-term and long-term ozone exposure on different ASCVD outcomes, including mortality and incidence of ischemic heart disease (IHD) and ischemic stroke (IS). ResultsA total of 24 studies were included based on a set of predetermined eligibility criteria. The meta-analysis results indicated that short-term ozone exposure was associated with an increased risk of ASCVD mortality and incidence. Specifically, short-term ozone exposure was significantly associated with an elevated risk of IHD mortality (combined RR=1.011, 95%CI: 1.008, 1.015; P < 0.05). Additionally, short-term ozone exposure was significantly linked to increased IS mortality (combined RR=1.005, 95%CI: 1.003, 1.008; P < 0.05) and incidence (combined RR=1.015, 95%CI: 1.003, 1.027; P < 0.05). ConclusionShort-term exposure to ambient ozone significantly elevates acute cardiovascular disease risk. However, the epidemiological association between long-term ozone exposure and ASCVD remains inconclusive. Future high-quality cohort studies with refined exposure assessment methods are warranted to elucidate the chronic cardiovascular effects of ozone exposure.http://www.jeom.org/article/cn/10.11836/JEOM24531ambient ozoneatherosclerotic cardiovascular diseaseshort-term exposurelong-term exposuremeta-analysis |
| spellingShingle | Bingqian WANG Teng YANG Shuting XIE Meng TAN Guoxing LI Jing HUANG Meta-analysis of association between atmospheric ozone exposure and atherosclerotic cardiovascular disease 环境与职业医学 ambient ozone atherosclerotic cardiovascular disease short-term exposure long-term exposure meta-analysis |
| title | Meta-analysis of association between atmospheric ozone exposure and atherosclerotic cardiovascular disease |
| title_full | Meta-analysis of association between atmospheric ozone exposure and atherosclerotic cardiovascular disease |
| title_fullStr | Meta-analysis of association between atmospheric ozone exposure and atherosclerotic cardiovascular disease |
| title_full_unstemmed | Meta-analysis of association between atmospheric ozone exposure and atherosclerotic cardiovascular disease |
| title_short | Meta-analysis of association between atmospheric ozone exposure and atherosclerotic cardiovascular disease |
| title_sort | meta analysis of association between atmospheric ozone exposure and atherosclerotic cardiovascular disease |
| topic | ambient ozone atherosclerotic cardiovascular disease short-term exposure long-term exposure meta-analysis |
| url | http://www.jeom.org/article/cn/10.11836/JEOM24531 |
| work_keys_str_mv | AT bingqianwang metaanalysisofassociationbetweenatmosphericozoneexposureandatheroscleroticcardiovasculardisease AT tengyang metaanalysisofassociationbetweenatmosphericozoneexposureandatheroscleroticcardiovasculardisease AT shutingxie metaanalysisofassociationbetweenatmosphericozoneexposureandatheroscleroticcardiovasculardisease AT mengtan metaanalysisofassociationbetweenatmosphericozoneexposureandatheroscleroticcardiovasculardisease AT guoxingli metaanalysisofassociationbetweenatmosphericozoneexposureandatheroscleroticcardiovasculardisease AT jinghuang metaanalysisofassociationbetweenatmosphericozoneexposureandatheroscleroticcardiovasculardisease |