When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD
Inflammatory bowel disease (IBD) is characterized by an impairment of the integrity of the mucosal epithelial barrier, which causes exacerbated inflammation of the intestine. The intestinal barrier is formed by different specialized epithelial cells, which separate the intestinal lumen from the lami...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/9765238 |
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| author | Esmé van der Gracht Sonja Zahner Mitchell Kronenberg |
| author_facet | Esmé van der Gracht Sonja Zahner Mitchell Kronenberg |
| author_sort | Esmé van der Gracht |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is characterized by an impairment of the integrity of the mucosal epithelial barrier, which causes exacerbated inflammation of the intestine. The intestinal barrier is formed by different specialized epithelial cells, which separate the intestinal lumen from the lamina propria. In addition to its crucial role in protecting the body from invading pathogens, the intestinal epithelium contributes to intestinal homeostasis by its biochemical properties and communication to underlying immune cells. Innate lymphoid cells (ILCs) are a recently described population of lymphocytes that have been implicated in both mucosal homeostasis and inflammation. Recent findings indicate a critical feedback loop in which damaged epithelium activates these innate immune cells to restore epithelial barrier function. This review will focus on the signalling pathways between damaged epithelium and ILCs involved in repair of the epithelial barrier and tissue homeostasis and the relationship of these processes with the control of IBD. |
| format | Article |
| id | doaj-art-cd0affaa65a54738b2a7e9316f323e24 |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cd0affaa65a54738b2a7e9316f323e242025-08-20T03:19:32ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/97652389765238When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBDEsmé van der Gracht0Sonja Zahner1Mitchell Kronenberg2Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USADivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USADivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USAInflammatory bowel disease (IBD) is characterized by an impairment of the integrity of the mucosal epithelial barrier, which causes exacerbated inflammation of the intestine. The intestinal barrier is formed by different specialized epithelial cells, which separate the intestinal lumen from the lamina propria. In addition to its crucial role in protecting the body from invading pathogens, the intestinal epithelium contributes to intestinal homeostasis by its biochemical properties and communication to underlying immune cells. Innate lymphoid cells (ILCs) are a recently described population of lymphocytes that have been implicated in both mucosal homeostasis and inflammation. Recent findings indicate a critical feedback loop in which damaged epithelium activates these innate immune cells to restore epithelial barrier function. This review will focus on the signalling pathways between damaged epithelium and ILCs involved in repair of the epithelial barrier and tissue homeostasis and the relationship of these processes with the control of IBD.http://dx.doi.org/10.1155/2016/9765238 |
| spellingShingle | Esmé van der Gracht Sonja Zahner Mitchell Kronenberg When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD Mediators of Inflammation |
| title | When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD |
| title_full | When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD |
| title_fullStr | When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD |
| title_full_unstemmed | When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD |
| title_short | When Insult Is Added to Injury: Cross Talk between ILCs and Intestinal Epithelium in IBD |
| title_sort | when insult is added to injury cross talk between ilcs and intestinal epithelium in ibd |
| url | http://dx.doi.org/10.1155/2016/9765238 |
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