Lung cancer screening in Finland: a prospective randomized trial
Background: Early detection of lung cancer with low-dose computed tomography (LDCT) screening can shift diagnoses to early-stage disease and improve survival. However, LDCT has several challenges such as high false positive rate and indefinite cost-effectiveness. We report here secondary and explora...
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Medical Journals Sweden
2025-06-01
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| Series: | Acta Oncologica |
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| Online Access: | https://medicaljournalssweden.se/actaoncologica/article/view/43093 |
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| author | Viktor Wichmann Sanna Iivanainen Lauri Mattila Veli-Pekka Kokkonen Airi Jartti Antti Kurtti Riitta Kaarteenaho Heidi Andersen Antti Jekunen Tuula Vasankari Jussi Koivunen |
| author_facet | Viktor Wichmann Sanna Iivanainen Lauri Mattila Veli-Pekka Kokkonen Airi Jartti Antti Kurtti Riitta Kaarteenaho Heidi Andersen Antti Jekunen Tuula Vasankari Jussi Koivunen |
| author_sort | Viktor Wichmann |
| collection | DOAJ |
| description | Background: Early detection of lung cancer with low-dose computed tomography (LDCT) screening can shift diagnoses to early-stage disease and improve survival. However, LDCT has several challenges such as high false positive rate and indefinite cost-effectiveness. We report here secondary and exploratory endpoints of the Low-dose CT screening for lung cancer combined with different smoking cessation approach in Finland (LDCT-SC-FI) study including recruitment channels, LDCT performance, and long-term smoking cessation.
Methods: In this study, we randomized 200 current smokers with a significant smoking history in 1:1 fashion to receive a smartphone application or standard of care written materials, both for smoking cessation. All underwent LDCT screening at baseline and at 1-year. Participants were recruited through multiple channels, including newspapers, internet advertisements, and healthcare referrals.
Results: Newspaper advertisements were the most effective recruitment method, accounting for 74.5% of participants while minority came through referrals (2.5%). LDCT screening demonstrated uptake of 96.7% for both rounds combined. Six lung cancers were detected with a positive predictive value of 75%. Of the detected lung cancers, five were at stage I and all of these underwent curative intent treatment. Smoking cessation rates at 1-year were higher in the application (18.3%) than in the control arm (12.8%), though the difference was not statistically significant (odds ratio [OR]: 1.53, 95% confidence interval [CI]: 0.69–3.41).
Interpretation: This study suggests that LDCT screening for lung cancer is feasible in Finland. The screening examination uptake was high with both screening rounds, while the positive predictive value for lung cancer detection remained at good level.
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| format | Article |
| id | doaj-art-cd093913c41e4ccb9777bdcf4a76f09c |
| institution | OA Journals |
| issn | 1651-226X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Oncologica |
| spelling | doaj-art-cd093913c41e4ccb9777bdcf4a76f09c2025-08-20T02:09:12ZengMedical Journals SwedenActa Oncologica1651-226X2025-06-016410.2340/1651-226X.2025.43093Lung cancer screening in Finland: a prospective randomized trialViktor Wichmann0Sanna Iivanainen1Lauri Mattila2Veli-Pekka Kokkonen3Airi Jartti4Antti Kurtti5Riitta Kaarteenaho6Heidi Andersen7Antti Jekunen8Tuula Vasankari9Jussi Koivunen10Cancer Center Oulu University Hospital, Oulu, Finland; University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu, FinlandCancer Center Oulu University Hospital, Oulu, Finland; University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu, FinlandDepartment of Diagnostic Radiology, Oulu University Hospital, Oulu, FinlandDepartment of Diagnostic Radiology, Oulu University Hospital, Oulu, FinlandDepartment of Diagnostic Radiology, Oulu University Hospital, Oulu, FinlandUniversity of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu, FinlandCenter of Internal Medicine and Respiratory Medicine, Oulu University Hospital, and Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, FinlandVaasa Central Hospital, Vaasa, Finland; University of Turku, Turku, FinlandVaasa Central Hospital, Vaasa, Finland; University of Turku, Turku, FinlandFilha, Helsinki, FinlandCancer Center Oulu University Hospital, Oulu, Finland; University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu, FinlandBackground: Early detection of lung cancer with low-dose computed tomography (LDCT) screening can shift diagnoses to early-stage disease and improve survival. However, LDCT has several challenges such as high false positive rate and indefinite cost-effectiveness. We report here secondary and exploratory endpoints of the Low-dose CT screening for lung cancer combined with different smoking cessation approach in Finland (LDCT-SC-FI) study including recruitment channels, LDCT performance, and long-term smoking cessation. Methods: In this study, we randomized 200 current smokers with a significant smoking history in 1:1 fashion to receive a smartphone application or standard of care written materials, both for smoking cessation. All underwent LDCT screening at baseline and at 1-year. Participants were recruited through multiple channels, including newspapers, internet advertisements, and healthcare referrals. Results: Newspaper advertisements were the most effective recruitment method, accounting for 74.5% of participants while minority came through referrals (2.5%). LDCT screening demonstrated uptake of 96.7% for both rounds combined. Six lung cancers were detected with a positive predictive value of 75%. Of the detected lung cancers, five were at stage I and all of these underwent curative intent treatment. Smoking cessation rates at 1-year were higher in the application (18.3%) than in the control arm (12.8%), though the difference was not statistically significant (odds ratio [OR]: 1.53, 95% confidence interval [CI]: 0.69–3.41). Interpretation: This study suggests that LDCT screening for lung cancer is feasible in Finland. The screening examination uptake was high with both screening rounds, while the positive predictive value for lung cancer detection remained at good level. https://medicaljournalssweden.se/actaoncologica/article/view/43093Lung Cancercancer screeningLDCTSmoking cessation |
| spellingShingle | Viktor Wichmann Sanna Iivanainen Lauri Mattila Veli-Pekka Kokkonen Airi Jartti Antti Kurtti Riitta Kaarteenaho Heidi Andersen Antti Jekunen Tuula Vasankari Jussi Koivunen Lung cancer screening in Finland: a prospective randomized trial Acta Oncologica Lung Cancer cancer screening LDCT Smoking cessation |
| title | Lung cancer screening in Finland: a prospective randomized trial |
| title_full | Lung cancer screening in Finland: a prospective randomized trial |
| title_fullStr | Lung cancer screening in Finland: a prospective randomized trial |
| title_full_unstemmed | Lung cancer screening in Finland: a prospective randomized trial |
| title_short | Lung cancer screening in Finland: a prospective randomized trial |
| title_sort | lung cancer screening in finland a prospective randomized trial |
| topic | Lung Cancer cancer screening LDCT Smoking cessation |
| url | https://medicaljournalssweden.se/actaoncologica/article/view/43093 |
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