The Incidence, Risk Factors and Characteristics of Late (>2 Years) Recurrence of Deep Venous Thrombosis
Objective Recurrent deep venous thrombosis (RDVT) is a relatively frequent phenomenon; however, scarce literature is available on late RDVT (>2 years). This study aimed to investigate the incidence, associated risk factors, and characteristics of late RDVT. Methods We conducted a retrospective an...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-04-01
|
| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296251332937 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849713175466868736 |
|---|---|
| author | Bo Wu MD Jian Fu MD Haiyang Wang MD Haiyan Yan MD Jianming Sun MD Haoyuan Wang MD Lili Zhang MD |
| author_facet | Bo Wu MD Jian Fu MD Haiyang Wang MD Haiyan Yan MD Jianming Sun MD Haoyuan Wang MD Lili Zhang MD |
| author_sort | Bo Wu MD |
| collection | DOAJ |
| description | Objective Recurrent deep venous thrombosis (RDVT) is a relatively frequent phenomenon; however, scarce literature is available on late RDVT (>2 years). This study aimed to investigate the incidence, associated risk factors, and characteristics of late RDVT. Methods We conducted a retrospective analysis of patients diagnosed with symptomatic lower extremity deep venous thrombosis (DVT) between April 2017 and April 2022. The incidence and mortality rates of late RDVT, as well as the demographic data, risk factors, and characteristics, were assessed. Additionally, a comprehensive Cox regression analysis was performed to evaluate 14 potential risk factors. Results Of the 638 patients with DVT, 89 (13.9%) experienced recurrence during a mean follow-up period of 30.10 ± 15.23 months. The RDVT group comprised 50 males and 39 females (the male-to-female ratio: 50/39), with a mean age of 64.08 ± 13.23 years (the age range: 26-88 years). Among them, early recurrence was observed in 57 (64%) patients, while late recurrence occurred in 32 (36%) after their initial symptomatic DVT episode. Late RDVT predominantly manifested in the contralateral lower extremity. Multivariate Cox regression analysis further identified proximal DVT, immobility, non-retrieved inferior vena cava filter (IVCF), and ≥50% stent extension into the inferior vena cava (IVC) as significant risk factors for late RDVT. Moreover, mortality among patients with late RDVT was low, with 2 (6.25%) dying during the follow-up period. Conclusions Late RDVT is relatively infrequent within the RDVT cohort and primarily manifests in the contralateral lower extremity. Furthermore, patients with late RDVT have a low mortality rate. Proximal DVT, immobility, non-retrieved IVCF, and ≥50% stent extension into the IVC are strongly correlated with the development of late RDVT. |
| format | Article |
| id | doaj-art-cd04a0ce48aa439e8431e5931d8ddfd2 |
| institution | DOAJ |
| issn | 1938-2723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj-art-cd04a0ce48aa439e8431e5931d8ddfd22025-08-20T03:14:01ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232025-04-013110.1177/10760296251332937The Incidence, Risk Factors and Characteristics of Late (>2 Years) Recurrence of Deep Venous ThrombosisBo Wu MD0Jian Fu MD1Haiyang Wang MD2Haiyan Yan MD3Jianming Sun MD4Haoyuan Wang MD5Lili Zhang MD6 Department of Abdominal Wall, Hernia and Vascular Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Department of Abdominal Wall, Hernia and Vascular Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Department of Abdominal Wall, Hernia and Vascular Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Department of Abdominal Wall, Hernia and Vascular Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Department of Abdominal Wall, Hernia and Vascular Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Department of Abdominal Wall, Hernia and Vascular Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China General Practice, Chongqing University Fuling Hospital, Chongqing, China Objective Recurrent deep venous thrombosis (RDVT) is a relatively frequent phenomenon; however, scarce literature is available on late RDVT (>2 years). This study aimed to investigate the incidence, associated risk factors, and characteristics of late RDVT. Methods We conducted a retrospective analysis of patients diagnosed with symptomatic lower extremity deep venous thrombosis (DVT) between April 2017 and April 2022. The incidence and mortality rates of late RDVT, as well as the demographic data, risk factors, and characteristics, were assessed. Additionally, a comprehensive Cox regression analysis was performed to evaluate 14 potential risk factors. Results Of the 638 patients with DVT, 89 (13.9%) experienced recurrence during a mean follow-up period of 30.10 ± 15.23 months. The RDVT group comprised 50 males and 39 females (the male-to-female ratio: 50/39), with a mean age of 64.08 ± 13.23 years (the age range: 26-88 years). Among them, early recurrence was observed in 57 (64%) patients, while late recurrence occurred in 32 (36%) after their initial symptomatic DVT episode. Late RDVT predominantly manifested in the contralateral lower extremity. Multivariate Cox regression analysis further identified proximal DVT, immobility, non-retrieved inferior vena cava filter (IVCF), and ≥50% stent extension into the inferior vena cava (IVC) as significant risk factors for late RDVT. Moreover, mortality among patients with late RDVT was low, with 2 (6.25%) dying during the follow-up period. Conclusions Late RDVT is relatively infrequent within the RDVT cohort and primarily manifests in the contralateral lower extremity. Furthermore, patients with late RDVT have a low mortality rate. Proximal DVT, immobility, non-retrieved IVCF, and ≥50% stent extension into the IVC are strongly correlated with the development of late RDVT.https://doi.org/10.1177/10760296251332937 |
| spellingShingle | Bo Wu MD Jian Fu MD Haiyang Wang MD Haiyan Yan MD Jianming Sun MD Haoyuan Wang MD Lili Zhang MD The Incidence, Risk Factors and Characteristics of Late (>2 Years) Recurrence of Deep Venous Thrombosis Clinical and Applied Thrombosis/Hemostasis |
| title | The Incidence, Risk Factors and Characteristics of Late (>2 Years) Recurrence of Deep Venous Thrombosis |
| title_full | The Incidence, Risk Factors and Characteristics of Late (>2 Years) Recurrence of Deep Venous Thrombosis |
| title_fullStr | The Incidence, Risk Factors and Characteristics of Late (>2 Years) Recurrence of Deep Venous Thrombosis |
| title_full_unstemmed | The Incidence, Risk Factors and Characteristics of Late (>2 Years) Recurrence of Deep Venous Thrombosis |
| title_short | The Incidence, Risk Factors and Characteristics of Late (>2 Years) Recurrence of Deep Venous Thrombosis |
| title_sort | incidence risk factors and characteristics of late 2 years recurrence of deep venous thrombosis |
| url | https://doi.org/10.1177/10760296251332937 |
| work_keys_str_mv | AT bowumd theincidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis AT jianfumd theincidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis AT haiyangwangmd theincidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis AT haiyanyanmd theincidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis AT jianmingsunmd theincidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis AT haoyuanwangmd theincidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis AT lilizhangmd theincidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis AT bowumd incidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis AT jianfumd incidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis AT haiyangwangmd incidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis AT haiyanyanmd incidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis AT jianmingsunmd incidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis AT haoyuanwangmd incidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis AT lilizhangmd incidenceriskfactorsandcharacteristicsoflate2yearsrecurrenceofdeepvenousthrombosis |