The Application of Hyaluronic Acid-Based Hydrogels in Bone and Cartilage Tissue Engineering
At present, the healing of osteopathy, especially the healing of cartilage, has been proven to be difficult. Commonly used treatment methods are autogenous bone grafts and allogeneic bone grafts, but grafts cannot fully meet the clinical treatment requirements due to problems related to the source,...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2019/3027303 |
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| author | Hongru Li Zhiping Qi Shuang Zheng Yuxin Chang Weijian Kong Chuan Fu Ziyuan Yu Xiaoyu Yang Su Pan |
| author_facet | Hongru Li Zhiping Qi Shuang Zheng Yuxin Chang Weijian Kong Chuan Fu Ziyuan Yu Xiaoyu Yang Su Pan |
| author_sort | Hongru Li |
| collection | DOAJ |
| description | At present, the healing of osteopathy, especially the healing of cartilage, has been proven to be difficult. Commonly used treatment methods are autogenous bone grafts and allogeneic bone grafts, but grafts cannot fully meet the clinical treatment requirements due to problems related to the source, price, immunity, and other concerns. Thus, the combination of biomaterials and tissue engineering technology has become a new direction in research. Among studies on tissue engineering bone and cartilage materials, hydrogels that show biological activity, absorbability after degradability, plasticity, and easy preparation have become the focus. Hydrogels are used as extracellular matrix mimics. Although various materials are able to form hydrogels, hyaluronic acid and its derivatives are prominently used. Hyaluronic acid hydrogels have many advantages, such as promoting cell adhesion and proliferation and wound healing. They also demonstrate sufficient biological activity for stimulating a microenvironment for cell survival. However, their disadvantages require further modification and include a poor degradation rate and insufficient mechanical performance. In this paper, hyaluronic acid-based hydrogels, their modifications, applications, and mechanisms, as well as new techniques for processing hyaluronic acid hydrogels in bone and cartilage tissue engineering, are briefly reviewed, and their future prospects and directions for future work are discussed. |
| format | Article |
| id | doaj-art-cd03f64ee0a34397b078aea475dc1744 |
| institution | Kabale University |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-cd03f64ee0a34397b078aea475dc17442025-02-03T05:51:54ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422019-01-01201910.1155/2019/30273033027303The Application of Hyaluronic Acid-Based Hydrogels in Bone and Cartilage Tissue EngineeringHongru Li0Zhiping Qi1Shuang Zheng2Yuxin Chang3Weijian Kong4Chuan Fu5Ziyuan Yu6Xiaoyu Yang7Su Pan8Department of Orthopedic Surgery, The Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun TX 130041, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun TX 130041, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun TX 130041, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun TX 130041, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun TX 130041, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun TX 130041, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun TX 130041, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun TX 130041, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Ziqiang Street No. 218, Changchun TX 130041, ChinaAt present, the healing of osteopathy, especially the healing of cartilage, has been proven to be difficult. Commonly used treatment methods are autogenous bone grafts and allogeneic bone grafts, but grafts cannot fully meet the clinical treatment requirements due to problems related to the source, price, immunity, and other concerns. Thus, the combination of biomaterials and tissue engineering technology has become a new direction in research. Among studies on tissue engineering bone and cartilage materials, hydrogels that show biological activity, absorbability after degradability, plasticity, and easy preparation have become the focus. Hydrogels are used as extracellular matrix mimics. Although various materials are able to form hydrogels, hyaluronic acid and its derivatives are prominently used. Hyaluronic acid hydrogels have many advantages, such as promoting cell adhesion and proliferation and wound healing. They also demonstrate sufficient biological activity for stimulating a microenvironment for cell survival. However, their disadvantages require further modification and include a poor degradation rate and insufficient mechanical performance. In this paper, hyaluronic acid-based hydrogels, their modifications, applications, and mechanisms, as well as new techniques for processing hyaluronic acid hydrogels in bone and cartilage tissue engineering, are briefly reviewed, and their future prospects and directions for future work are discussed.http://dx.doi.org/10.1155/2019/3027303 |
| spellingShingle | Hongru Li Zhiping Qi Shuang Zheng Yuxin Chang Weijian Kong Chuan Fu Ziyuan Yu Xiaoyu Yang Su Pan The Application of Hyaluronic Acid-Based Hydrogels in Bone and Cartilage Tissue Engineering Advances in Materials Science and Engineering |
| title | The Application of Hyaluronic Acid-Based Hydrogels in Bone and Cartilage Tissue Engineering |
| title_full | The Application of Hyaluronic Acid-Based Hydrogels in Bone and Cartilage Tissue Engineering |
| title_fullStr | The Application of Hyaluronic Acid-Based Hydrogels in Bone and Cartilage Tissue Engineering |
| title_full_unstemmed | The Application of Hyaluronic Acid-Based Hydrogels in Bone and Cartilage Tissue Engineering |
| title_short | The Application of Hyaluronic Acid-Based Hydrogels in Bone and Cartilage Tissue Engineering |
| title_sort | application of hyaluronic acid based hydrogels in bone and cartilage tissue engineering |
| url | http://dx.doi.org/10.1155/2019/3027303 |
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