Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary Syndrome
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by hyperandrogenism, insulin resistance, and dyslipidemia. Inflammation and oxidative stress play critical roles in its pathogenesis. This observational cross-sectional study evaluated the relationship between se...
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| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1994_24 |
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| author | Neelam Gusain Ashish Anjankar Ranjit Ambad |
| author_facet | Neelam Gusain Ashish Anjankar Ranjit Ambad |
| author_sort | Neelam Gusain |
| collection | DOAJ |
| description | Introduction:
Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by hyperandrogenism, insulin resistance, and dyslipidemia. Inflammation and oxidative stress play critical roles in its pathogenesis. This observational cross-sectional study evaluated the relationship between serum Caspase-1, interleukin-10 (IL-10), homeostatic model assessment of insulin resistance (HOMA-IR), free androgen index (FAI), lipid profiles, and oxidative stress markers in women with PCOS.
Materials and Methods:
A total of 150 women diagnosed with PCOS participated in this study. Serum levels of Caspase-1, IL-10, HOMA-IR, FAI, lipid profiles (total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides), malondialdehyde (MDA), and superoxide dismutase (SOD) were measured.
Results:
The results revealed significant elevations in Caspase-1, HOMA-IR, and lipid profiles, while IL-10 levels were lower compared to normal populations. Additionally, oxidative stress markers, including MDA, were significantly increased, while SOD levels showed a decline. Positive correlations were observed between Caspase-1, HOMA-IR, dyslipidemia, and oxidative stress markers.
Conclusion:
These findings suggest a crucial link between inflammation, insulin resistance, and oxidative stress in PCOS, contributing to its complex pathophysiology. |
| format | Article |
| id | doaj-art-cd03beb280fe43b9a147d39f2bfc3424 |
| institution | OA Journals |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-cd03beb280fe43b9a147d39f2bfc34242025-08-20T02:03:24ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-05-0117Suppl 1S369S37110.4103/jpbs.jpbs_1994_24Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary SyndromeNeelam GusainAshish AnjankarRanjit AmbadIntroduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by hyperandrogenism, insulin resistance, and dyslipidemia. Inflammation and oxidative stress play critical roles in its pathogenesis. This observational cross-sectional study evaluated the relationship between serum Caspase-1, interleukin-10 (IL-10), homeostatic model assessment of insulin resistance (HOMA-IR), free androgen index (FAI), lipid profiles, and oxidative stress markers in women with PCOS. Materials and Methods: A total of 150 women diagnosed with PCOS participated in this study. Serum levels of Caspase-1, IL-10, HOMA-IR, FAI, lipid profiles (total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides), malondialdehyde (MDA), and superoxide dismutase (SOD) were measured. Results: The results revealed significant elevations in Caspase-1, HOMA-IR, and lipid profiles, while IL-10 levels were lower compared to normal populations. Additionally, oxidative stress markers, including MDA, were significantly increased, while SOD levels showed a decline. Positive correlations were observed between Caspase-1, HOMA-IR, dyslipidemia, and oxidative stress markers. Conclusion: These findings suggest a crucial link between inflammation, insulin resistance, and oxidative stress in PCOS, contributing to its complex pathophysiology.https://journals.lww.com/10.4103/jpbs.jpbs_1994_24caspase-1free androgen indexhdlhoma-iril-10ldlpcostotal cholesteroltriglyceridesand mda |
| spellingShingle | Neelam Gusain Ashish Anjankar Ranjit Ambad Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary Syndrome Journal of Pharmacy and Bioallied Sciences caspase-1 free androgen index hdl homa-ir il-10 ldl pcos total cholesterol triglycerides and mda |
| title | Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary Syndrome |
| title_full | Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary Syndrome |
| title_fullStr | Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary Syndrome |
| title_full_unstemmed | Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary Syndrome |
| title_short | Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary Syndrome |
| title_sort | correlation between serum caspase 1 il 10 homa ir fai dyslipidemia and oxidative stress status in women with polycystic ovary syndrome |
| topic | caspase-1 free androgen index hdl homa-ir il-10 ldl pcos total cholesterol triglycerides and mda |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1994_24 |
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