Effect of in-situ application of simvastatin gel in surgical management of osseous defects in chronic periodontitis–A randomized clinical trial
Background: The present randomized controlled clinical study was designed to investigate the effect of in situ application of 1.2 mg Simvastatin (SV) gel in the surgical management of Intrabony defects in chronic periodontitis patients. Methodology: 20 patients contributing 40 sites were categorized...
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| Language: | English |
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Elsevier
2017-05-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426817300465 |
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| author | Rajeev Ranjan Sudhir R. Patil Veena H.R. |
| author_facet | Rajeev Ranjan Sudhir R. Patil Veena H.R. |
| author_sort | Rajeev Ranjan |
| collection | DOAJ |
| description | Background: The present randomized controlled clinical study was designed to investigate the effect of in situ application of 1.2 mg Simvastatin (SV) gel in the surgical management of Intrabony defects in chronic periodontitis patients. Methodology: 20 patients contributing 40 sites were categorized into two treatment groups: Open flap debridement plus 1.2 mg SV gel (Group 1) and Open flap debridement plus Placebo gel (Group 2). Gingival index (GI), Plaque index (PI), Pocket depth (PD) and clinical attachment level (CAL) were recorded at baseline, 3 months, 6 months and 9 months. At baseline and at the end of 6 and 9 months Radiographic evaluation of Intrabony defect fill was done using Image j software. Results: Significant reduction of GI, PD and gain in CAL was observed at the end of 9 months in both groups. Amount of bone fill and percentage of original defect fill in Group 1 was statistically highly significant than Group 2 at the end of 6 and 9 months. Conclusion: Higher amount of decrease in GI and PD along with more amount of CAL gain was observed in treatment group than control group. Radiological assessment confirmed that significant intrabony defect fill and percentage fill of original defect in treatment group than controlled group. |
| format | Article |
| id | doaj-art-cd02b72f0e2547ed882ddc05ccc1df06 |
| institution | OA Journals |
| issn | 2212-4268 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | Elsevier |
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| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-cd02b72f0e2547ed882ddc05ccc1df062025-08-20T02:01:58ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682017-05-017211311810.1016/j.jobcr.2017.05.005Effect of in-situ application of simvastatin gel in surgical management of osseous defects in chronic periodontitis–A randomized clinical trialRajeev Ranjan0Sudhir R. Patil1Veena H.R.2Department of Periodontics and Oral Implantology, Kalinga Institute of Dental Sciences, Campus 5, KIIT University, Patia, Bhubaneswar, Odisha, 751024, India; Corresponding author.Department of Periodontics, K.L.E Society’s Institute of Dental Sciences, Number 20, Tumkur Road, Yeshavanthpur Suburbs, suburb Bangalore, 560022, IndiaDepartment of Periodontics, K.L.E Society’s Institute of Dental Sciences, Number 20, Tumkur Road, Yeshavanthpur Suburbs, suburb Bangalore, 560022, IndiaBackground: The present randomized controlled clinical study was designed to investigate the effect of in situ application of 1.2 mg Simvastatin (SV) gel in the surgical management of Intrabony defects in chronic periodontitis patients. Methodology: 20 patients contributing 40 sites were categorized into two treatment groups: Open flap debridement plus 1.2 mg SV gel (Group 1) and Open flap debridement plus Placebo gel (Group 2). Gingival index (GI), Plaque index (PI), Pocket depth (PD) and clinical attachment level (CAL) were recorded at baseline, 3 months, 6 months and 9 months. At baseline and at the end of 6 and 9 months Radiographic evaluation of Intrabony defect fill was done using Image j software. Results: Significant reduction of GI, PD and gain in CAL was observed at the end of 9 months in both groups. Amount of bone fill and percentage of original defect fill in Group 1 was statistically highly significant than Group 2 at the end of 6 and 9 months. Conclusion: Higher amount of decrease in GI and PD along with more amount of CAL gain was observed in treatment group than control group. Radiological assessment confirmed that significant intrabony defect fill and percentage fill of original defect in treatment group than controlled group.http://www.sciencedirect.com/science/article/pii/S2212426817300465Chronic PeriodontitisSimvastatinosseous defectsdefect fill |
| spellingShingle | Rajeev Ranjan Sudhir R. Patil Veena H.R. Effect of in-situ application of simvastatin gel in surgical management of osseous defects in chronic periodontitis–A randomized clinical trial Journal of Oral Biology and Craniofacial Research Chronic Periodontitis Simvastatin osseous defects defect fill |
| title | Effect of in-situ application of simvastatin gel in surgical management of osseous defects in chronic periodontitis–A randomized clinical trial |
| title_full | Effect of in-situ application of simvastatin gel in surgical management of osseous defects in chronic periodontitis–A randomized clinical trial |
| title_fullStr | Effect of in-situ application of simvastatin gel in surgical management of osseous defects in chronic periodontitis–A randomized clinical trial |
| title_full_unstemmed | Effect of in-situ application of simvastatin gel in surgical management of osseous defects in chronic periodontitis–A randomized clinical trial |
| title_short | Effect of in-situ application of simvastatin gel in surgical management of osseous defects in chronic periodontitis–A randomized clinical trial |
| title_sort | effect of in situ application of simvastatin gel in surgical management of osseous defects in chronic periodontitis a randomized clinical trial |
| topic | Chronic Periodontitis Simvastatin osseous defects defect fill |
| url | http://www.sciencedirect.com/science/article/pii/S2212426817300465 |
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