Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality
Abstract Although studies have examined the association of the Relative Fat Mass (RFM, a novel anthropometric index used as a surrogate for whole-body fat percentage) with all-cause mortality, the association of RFM with diabetes-related mortality and heart disease mortality has not been thoroughly...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-81497-6 |
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| author | Orison O. Woolcott Edgar Samarasundera Alicia K. Heath |
| author_facet | Orison O. Woolcott Edgar Samarasundera Alicia K. Heath |
| author_sort | Orison O. Woolcott |
| collection | DOAJ |
| description | Abstract Although studies have examined the association of the Relative Fat Mass (RFM, a novel anthropometric index used as a surrogate for whole-body fat percentage) with all-cause mortality, the association of RFM with diabetes-related mortality and heart disease mortality has not been thoroughly investigated. In addition, no study has compared the associations of RFM and waist circumference (a surrogate for intra-abdominal fat) with cause-specific mortality and all-cause mortality. In the present study, we addressed these knowledge gaps. We used data from the US National Health and Nutrition Examination Survey (NHANES) 1999–2018. NHANES III was used for validation. Analyses included 46,535 adults (mean age 46.5 years). During a median follow-up time of 9.7 years, 6,101 participants died (743 from diabetes; 1,514 from heart disease). Compared with BMI and WC, RFM was more strongly associated with diabetes-related mortality in both women and men, adjusting for age, ethnicity, education, and smoking status. All anthropometric measures were similarly strongly associated with heart disease mortality and all-cause mortality. RFM showed greater predictive discrimination of mortality. Similar results were found in NHANES III (n = 14,448). In conclusion, RFM is strongly associated with diabetes-related mortality, heart disease mortality, and all-cause mortality, and outperforms conventional adiposity measures for prediction of mortality. |
| format | Article |
| id | doaj-art-ccf564cebede48d5824991f640175a31 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-ccf564cebede48d5824991f640175a312025-08-20T02:39:35ZengNature PortfolioScientific Reports2045-23222024-12-0114111210.1038/s41598-024-81497-6Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortalityOrison O. Woolcott0Edgar Samarasundera1Alicia K. Heath2School of Public Health, Faculty of Medicine, Imperial College LondonSchool of Public Health, Faculty of Medicine, Imperial College LondonSchool of Public Health, Faculty of Medicine, Imperial College LondonAbstract Although studies have examined the association of the Relative Fat Mass (RFM, a novel anthropometric index used as a surrogate for whole-body fat percentage) with all-cause mortality, the association of RFM with diabetes-related mortality and heart disease mortality has not been thoroughly investigated. In addition, no study has compared the associations of RFM and waist circumference (a surrogate for intra-abdominal fat) with cause-specific mortality and all-cause mortality. In the present study, we addressed these knowledge gaps. We used data from the US National Health and Nutrition Examination Survey (NHANES) 1999–2018. NHANES III was used for validation. Analyses included 46,535 adults (mean age 46.5 years). During a median follow-up time of 9.7 years, 6,101 participants died (743 from diabetes; 1,514 from heart disease). Compared with BMI and WC, RFM was more strongly associated with diabetes-related mortality in both women and men, adjusting for age, ethnicity, education, and smoking status. All anthropometric measures were similarly strongly associated with heart disease mortality and all-cause mortality. RFM showed greater predictive discrimination of mortality. Similar results were found in NHANES III (n = 14,448). In conclusion, RFM is strongly associated with diabetes-related mortality, heart disease mortality, and all-cause mortality, and outperforms conventional adiposity measures for prediction of mortality.https://doi.org/10.1038/s41598-024-81497-6Abdominal obesityDiabetes mortalityGeneral obesityHeart disease mortalityRelative fat mass |
| spellingShingle | Orison O. Woolcott Edgar Samarasundera Alicia K. Heath Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality Scientific Reports Abdominal obesity Diabetes mortality General obesity Heart disease mortality Relative fat mass |
| title | Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality |
| title_full | Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality |
| title_fullStr | Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality |
| title_full_unstemmed | Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality |
| title_short | Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality |
| title_sort | association of relative fat mass rfm index with diabetes related mortality and heart disease mortality |
| topic | Abdominal obesity Diabetes mortality General obesity Heart disease mortality Relative fat mass |
| url | https://doi.org/10.1038/s41598-024-81497-6 |
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