A Nomogram Based on Immune Inflammation Indicators for Rotaviral Diarrhea in Children Under 5 years Old: A Single-Center Retrospective Cohort Study
Jing Chen,1,* Xiao Chen,2,* Xiaoling Huang,1 Jia Liu,1 Qingfeng Yu1 1Department of Pediatrics, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China; 2Department of Orthopedics, The First People’s Hospital of Neijiang, Neijiang, Sichuan, Peopl...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-07-01
|
| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/a-nomogram-based-on-immune-inflammation-indicators-for-rotaviral-diarr-peer-reviewed-fulltext-article-JIR |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850077888152338432 |
|---|---|
| author | Chen J Chen X Huang X Liu J Yu Q |
| author_facet | Chen J Chen X Huang X Liu J Yu Q |
| author_sort | Chen J |
| collection | DOAJ |
| description | Jing Chen,1,* Xiao Chen,2,* Xiaoling Huang,1 Jia Liu,1 Qingfeng Yu1 1Department of Pediatrics, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China; 2Department of Orthopedics, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Chen, Department of Pediatrics, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China, Email 983394631@qq.comObjective: This study investigates the relationship between immune inflammation indicators and rotaviral-induced diarrhea in children under five years old.Methods: This retrospective cohort study included 439 children with diarrhea between January 2022 and December 2023. Clinical and laboratory data were retrospectively collected. The least absolute shrinkage and selection operator (LASSO), univariate, and multivariate logistic regression analyses were used to identify the risk factors in the training cohort, which were used to develop a nomogram model. The accuracy of the nomogram was assessed using a calibration plot. Finally, Decision curve analysis was used to examine the clinical utility of the nomogram, and internal validation was performed in the training set.Results: Among the 439 children, 120 developed rotaviral-induced diarrhea, with a prevalence rate of 27.33%. The systemic inflammatory response index (SIRI), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-albumin ratio (NAR), and C-reactive protein-to-albumin ratio (CAR) were identified as independent predictors of rotaviral diarrhea in the training cohort. A nomogram model was established using multivariable logistic analysis, with an AUC of 0.795 (95% CI, 0.743– 0.848) in the training set and 0.787 (95% CI, 0.694– 0.879) in the validation set. Calibration curves indicated strong agreement between the predicted and actual probabilities. Decision curve analysis demonstrated substantial net benefits of the nomogram model for predicting the risk of rotaviral diarrhea in these children.Conclusion: This study confirms that the immune inflammation indicators SIRI, LMR, NAR, and CAR predict the risk of rotaviral diarrhea in children under five years old. The nomogram model developed using these indicators demonstrates excellent predictive capability for the risk of rotaviral diarrhea.Keywords: rotaviral diarrhea, children, immune inflammation indicators, nomogram |
| format | Article |
| id | doaj-art-ccef1278101049a69540ffa381a4d424 |
| institution | DOAJ |
| issn | 1178-7031 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj-art-ccef1278101049a69540ffa381a4d4242025-08-20T02:45:42ZengDove Medical PressJournal of Inflammation Research1178-70312025-07-01Volume 18Issue 198919903105131A Nomogram Based on Immune Inflammation Indicators for Rotaviral Diarrhea in Children Under 5 years Old: A Single-Center Retrospective Cohort StudyChen J0Chen X1Huang X2Liu J3Yu Q4PediatricsOrthopedic SurgeryPediatricsPediatricsPediatricsJing Chen,1,* Xiao Chen,2,* Xiaoling Huang,1 Jia Liu,1 Qingfeng Yu1 1Department of Pediatrics, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China; 2Department of Orthopedics, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Chen, Department of Pediatrics, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China, Email 983394631@qq.comObjective: This study investigates the relationship between immune inflammation indicators and rotaviral-induced diarrhea in children under five years old.Methods: This retrospective cohort study included 439 children with diarrhea between January 2022 and December 2023. Clinical and laboratory data were retrospectively collected. The least absolute shrinkage and selection operator (LASSO), univariate, and multivariate logistic regression analyses were used to identify the risk factors in the training cohort, which were used to develop a nomogram model. The accuracy of the nomogram was assessed using a calibration plot. Finally, Decision curve analysis was used to examine the clinical utility of the nomogram, and internal validation was performed in the training set.Results: Among the 439 children, 120 developed rotaviral-induced diarrhea, with a prevalence rate of 27.33%. The systemic inflammatory response index (SIRI), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-albumin ratio (NAR), and C-reactive protein-to-albumin ratio (CAR) were identified as independent predictors of rotaviral diarrhea in the training cohort. A nomogram model was established using multivariable logistic analysis, with an AUC of 0.795 (95% CI, 0.743– 0.848) in the training set and 0.787 (95% CI, 0.694– 0.879) in the validation set. Calibration curves indicated strong agreement between the predicted and actual probabilities. Decision curve analysis demonstrated substantial net benefits of the nomogram model for predicting the risk of rotaviral diarrhea in these children.Conclusion: This study confirms that the immune inflammation indicators SIRI, LMR, NAR, and CAR predict the risk of rotaviral diarrhea in children under five years old. The nomogram model developed using these indicators demonstrates excellent predictive capability for the risk of rotaviral diarrhea.Keywords: rotaviral diarrhea, children, immune inflammation indicators, nomogramhttps://www.dovepress.com/a-nomogram-based-on-immune-inflammation-indicators-for-rotaviral-diarr-peer-reviewed-fulltext-article-JIRRotaviral diarrheachildrenimmune inflammation indicatorsnomogram |
| spellingShingle | Chen J Chen X Huang X Liu J Yu Q A Nomogram Based on Immune Inflammation Indicators for Rotaviral Diarrhea in Children Under 5 years Old: A Single-Center Retrospective Cohort Study Journal of Inflammation Research Rotaviral diarrhea children immune inflammation indicators nomogram |
| title | A Nomogram Based on Immune Inflammation Indicators for Rotaviral Diarrhea in Children Under 5 years Old: A Single-Center Retrospective Cohort Study |
| title_full | A Nomogram Based on Immune Inflammation Indicators for Rotaviral Diarrhea in Children Under 5 years Old: A Single-Center Retrospective Cohort Study |
| title_fullStr | A Nomogram Based on Immune Inflammation Indicators for Rotaviral Diarrhea in Children Under 5 years Old: A Single-Center Retrospective Cohort Study |
| title_full_unstemmed | A Nomogram Based on Immune Inflammation Indicators for Rotaviral Diarrhea in Children Under 5 years Old: A Single-Center Retrospective Cohort Study |
| title_short | A Nomogram Based on Immune Inflammation Indicators for Rotaviral Diarrhea in Children Under 5 years Old: A Single-Center Retrospective Cohort Study |
| title_sort | nomogram based on immune inflammation indicators for rotaviral diarrhea in children under 5 years old a single center retrospective cohort study |
| topic | Rotaviral diarrhea children immune inflammation indicators nomogram |
| url | https://www.dovepress.com/a-nomogram-based-on-immune-inflammation-indicators-for-rotaviral-diarr-peer-reviewed-fulltext-article-JIR |
| work_keys_str_mv | AT chenj anomogrambasedonimmuneinflammationindicatorsforrotaviraldiarrheainchildrenunder5yearsoldasinglecenterretrospectivecohortstudy AT chenx anomogrambasedonimmuneinflammationindicatorsforrotaviraldiarrheainchildrenunder5yearsoldasinglecenterretrospectivecohortstudy AT huangx anomogrambasedonimmuneinflammationindicatorsforrotaviraldiarrheainchildrenunder5yearsoldasinglecenterretrospectivecohortstudy AT liuj anomogrambasedonimmuneinflammationindicatorsforrotaviraldiarrheainchildrenunder5yearsoldasinglecenterretrospectivecohortstudy AT yuq anomogrambasedonimmuneinflammationindicatorsforrotaviraldiarrheainchildrenunder5yearsoldasinglecenterretrospectivecohortstudy AT chenj nomogrambasedonimmuneinflammationindicatorsforrotaviraldiarrheainchildrenunder5yearsoldasinglecenterretrospectivecohortstudy AT chenx nomogrambasedonimmuneinflammationindicatorsforrotaviraldiarrheainchildrenunder5yearsoldasinglecenterretrospectivecohortstudy AT huangx nomogrambasedonimmuneinflammationindicatorsforrotaviraldiarrheainchildrenunder5yearsoldasinglecenterretrospectivecohortstudy AT liuj nomogrambasedonimmuneinflammationindicatorsforrotaviraldiarrheainchildrenunder5yearsoldasinglecenterretrospectivecohortstudy AT yuq nomogrambasedonimmuneinflammationindicatorsforrotaviraldiarrheainchildrenunder5yearsoldasinglecenterretrospectivecohortstudy |