Roles of TGF-β Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis
Most cardiac diseases caused by inflammation are associated with fibrosis in the heart. Fibrosis is characterized by the accumulation of fibroblasts and excess deposition of extracellular matrix (ECM), which results in the distorted organ architecture and function. Recent studies revealed that cardi...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.4061/2011/724080 |
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| _version_ | 1850173328790126592 |
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| author | Yasuhiro Yoshimatsu Tetsuro Watabe |
| author_facet | Yasuhiro Yoshimatsu Tetsuro Watabe |
| author_sort | Yasuhiro Yoshimatsu |
| collection | DOAJ |
| description | Most cardiac diseases caused by inflammation are associated with fibrosis in the heart. Fibrosis is characterized by the accumulation of fibroblasts and excess deposition of extracellular matrix (ECM), which results in the distorted organ architecture and function. Recent studies revealed that cardiac fibroblasts are heterogeneous with multiple origins. Endothelial-mesenchymal transition (EndMT) plays important roles in the formation of cardiac fibroblasts during pathological settings. EndMT is regulated by signaling pathways mediated by cytokines including transforming growth factor (TGF)-β. Better understanding of the mechanisms of the formation of cardiac fibroblasts via EndMT may provide an opportunity to develop therapeutic strategies to cure heart diseases. |
| format | Article |
| id | doaj-art-ccedc531cc5a468980b52f6bbcd7615b |
| institution | OA Journals |
| issn | 2042-0099 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-ccedc531cc5a468980b52f6bbcd7615b2025-08-20T02:19:52ZengWileyInternational Journal of Inflammation2042-00992011-01-01201110.4061/2011/724080724080Roles of TGF-β Signals in Endothelial-Mesenchymal Transition during Cardiac FibrosisYasuhiro Yoshimatsu0Tetsuro Watabe1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku,Tokyo 113-0033, JapanDepartment of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku,Tokyo 113-0033, JapanMost cardiac diseases caused by inflammation are associated with fibrosis in the heart. Fibrosis is characterized by the accumulation of fibroblasts and excess deposition of extracellular matrix (ECM), which results in the distorted organ architecture and function. Recent studies revealed that cardiac fibroblasts are heterogeneous with multiple origins. Endothelial-mesenchymal transition (EndMT) plays important roles in the formation of cardiac fibroblasts during pathological settings. EndMT is regulated by signaling pathways mediated by cytokines including transforming growth factor (TGF)-β. Better understanding of the mechanisms of the formation of cardiac fibroblasts via EndMT may provide an opportunity to develop therapeutic strategies to cure heart diseases.http://dx.doi.org/10.4061/2011/724080 |
| spellingShingle | Yasuhiro Yoshimatsu Tetsuro Watabe Roles of TGF-β Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis International Journal of Inflammation |
| title | Roles of TGF-β
Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis |
| title_full | Roles of TGF-β
Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis |
| title_fullStr | Roles of TGF-β
Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis |
| title_full_unstemmed | Roles of TGF-β
Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis |
| title_short | Roles of TGF-β
Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis |
| title_sort | roles of tgf β signals in endothelial mesenchymal transition during cardiac fibrosis |
| url | http://dx.doi.org/10.4061/2011/724080 |
| work_keys_str_mv | AT yasuhiroyoshimatsu rolesoftgfbsignalsinendothelialmesenchymaltransitionduringcardiacfibrosis AT tetsurowatabe rolesoftgfbsignalsinendothelialmesenchymaltransitionduringcardiacfibrosis |