Cyclosporine A Combined with Rituximab Successfully Treated Erythropoietin-Induced Pure Red Blood Cell Aplastic Anemia
Introduction: Erythropoietin-induced pure red blood cell aplastic anemia (EPO-PRCA) is a rare anemia, which presents a significant treatment challenge, often necessitating the cessation of erythropoiesis-stimulating agents and the adoption of immunosuppressive therapies or renal transplan...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2025-03-01
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| Series: | Case Reports in Nephrology and Dialysis |
| Online Access: | https://karger.com/article/doi/10.1159/000543844 |
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| author | Honghui Zeng Hong He Xintian Shi Ying Wang Xin Wei |
| author_facet | Honghui Zeng Hong He Xintian Shi Ying Wang Xin Wei |
| author_sort | Honghui Zeng |
| collection | DOAJ |
| description |
Introduction: Erythropoietin-induced pure red blood cell aplastic anemia (EPO-PRCA) is a rare anemia, which presents a significant treatment challenge, often necessitating the cessation of erythropoiesis-stimulating agents and the adoption of immunosuppressive therapies or renal transplantation. Case Presentation: In the present case, the patient developed severe anemia after 2-year EPO treatment and was diagnosed with EPO-PRCA. The treatment with the full dose of corticosteroids and testosterone for 1 month failed to increase his hemoglobin level significantly. Therefore, the patient received the combination therapy of cyclosporine A (CsA) with rituximab, which effectively cleared the anti-EPO antibody. Then, roxadustat was given to improve renal anemia. As Hb level increased gradually, the patient was recovered from EPO-PRCA. Conclusion: This case reported an EPO-PRCA patient was successfully cured by the combination of CsA with rituximab and provided another choice for the treatment of EPO-PRCA in the future. |
| format | Article |
| id | doaj-art-cce97d19a31c4c938fcddfdb304a754d |
| institution | DOAJ |
| issn | 2296-9705 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Nephrology and Dialysis |
| spelling | doaj-art-cce97d19a31c4c938fcddfdb304a754d2025-08-20T03:09:48ZengKarger PublishersCase Reports in Nephrology and Dialysis2296-97052025-03-01151535910.1159/000543844Cyclosporine A Combined with Rituximab Successfully Treated Erythropoietin-Induced Pure Red Blood Cell Aplastic AnemiaHonghui ZengHong HeXintian ShiYing WangXin Wei Introduction: Erythropoietin-induced pure red blood cell aplastic anemia (EPO-PRCA) is a rare anemia, which presents a significant treatment challenge, often necessitating the cessation of erythropoiesis-stimulating agents and the adoption of immunosuppressive therapies or renal transplantation. Case Presentation: In the present case, the patient developed severe anemia after 2-year EPO treatment and was diagnosed with EPO-PRCA. The treatment with the full dose of corticosteroids and testosterone for 1 month failed to increase his hemoglobin level significantly. Therefore, the patient received the combination therapy of cyclosporine A (CsA) with rituximab, which effectively cleared the anti-EPO antibody. Then, roxadustat was given to improve renal anemia. As Hb level increased gradually, the patient was recovered from EPO-PRCA. Conclusion: This case reported an EPO-PRCA patient was successfully cured by the combination of CsA with rituximab and provided another choice for the treatment of EPO-PRCA in the future. https://karger.com/article/doi/10.1159/000543844 |
| spellingShingle | Honghui Zeng Hong He Xintian Shi Ying Wang Xin Wei Cyclosporine A Combined with Rituximab Successfully Treated Erythropoietin-Induced Pure Red Blood Cell Aplastic Anemia Case Reports in Nephrology and Dialysis |
| title | Cyclosporine A Combined with Rituximab Successfully Treated Erythropoietin-Induced Pure Red Blood Cell Aplastic Anemia |
| title_full | Cyclosporine A Combined with Rituximab Successfully Treated Erythropoietin-Induced Pure Red Blood Cell Aplastic Anemia |
| title_fullStr | Cyclosporine A Combined with Rituximab Successfully Treated Erythropoietin-Induced Pure Red Blood Cell Aplastic Anemia |
| title_full_unstemmed | Cyclosporine A Combined with Rituximab Successfully Treated Erythropoietin-Induced Pure Red Blood Cell Aplastic Anemia |
| title_short | Cyclosporine A Combined with Rituximab Successfully Treated Erythropoietin-Induced Pure Red Blood Cell Aplastic Anemia |
| title_sort | cyclosporine a combined with rituximab successfully treated erythropoietin induced pure red blood cell aplastic anemia |
| url | https://karger.com/article/doi/10.1159/000543844 |
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