Stronger associations of abdominal obesity-related triglyceride-glucose indices with type 2 diabetes compared to general obesity-related indices in community-dwelling Chinese adults: a cross-sectional study
ObjectivesThe relationships between the triglyceride-glucose (TyG) index, TyG-related parameters of different obesity phenotypes and the risk of type 2 diabetes (T2D) remain unclear. We aimed to determine associations between TyG index, obesity-related TyG parameters and T2D risk in Chinese adults.M...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1526849/full |
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| author | Xiaoting Lu Shanshan Chen Cheng Wang Diaozhu Lin Fengyi He Xiuhong Lin Hongshi Wu Ping Liang Li Yan Meng Ren Chaogang Chen |
| author_facet | Xiaoting Lu Shanshan Chen Cheng Wang Diaozhu Lin Fengyi He Xiuhong Lin Hongshi Wu Ping Liang Li Yan Meng Ren Chaogang Chen |
| author_sort | Xiaoting Lu |
| collection | DOAJ |
| description | ObjectivesThe relationships between the triglyceride-glucose (TyG) index, TyG-related parameters of different obesity phenotypes and the risk of type 2 diabetes (T2D) remain unclear. We aimed to determine associations between TyG index, obesity-related TyG parameters and T2D risk in Chinese adults.MethodsThis cross-sectional study included 9489 participants aged ≥40 years from a large scale, community-based cohort study. Multivariable logistic regression was performed to estimate odds ratios (ORs) and 95% confidence intervals (CIs). The receiver operating characteristic (ROC) curve was employed to test and compare the predictive power of obesity-related TyG parameters across different phenotypes for the risk of T2D.ResultsA total of 2081 (21.9%) participants with T2D were identified. When comparing with participants in the bottom quartile of TyG index, a heightened risk of T2D was observed among the highest quartile group, with an adjusted OR of 5.89 (95% CI: 4.98–6.98). Comparable relationships were found between obesity-related TyG indices and T2D, including TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), TyG-body mass index (TyG-BMI) and TyG-body fat percentage (TyG-BFP). Abdominal obesity-related TyG indices had the highest predictive capability for T2D, with the area under the curve (AUC) was 0.711 (0.697–0.724) for TyG-WHtR and 0.705 (0.691–0.719) for TyG-WC, which was superior to the general obesity-related TyG indices, with the AUC were 0.683 (0.669–0.698) and 0.631 (0.616–0.646) for TyG-BMI and TyG-BFP, respectively.ConclusionsOur findings demonstrate a positive associations between TyG index, obesity-related TyG indices and risk of T2D. Abdominal obesity-related TyG indices had a better predictive value to diabetes than general obesity-related TyG indices. |
| format | Article |
| id | doaj-art-cce9407e72cb4fcf9c97069d82f0b652 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-cce9407e72cb4fcf9c97069d82f0b6522025-08-20T03:10:20ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-06-011610.3389/fendo.2025.15268491526849Stronger associations of abdominal obesity-related triglyceride-glucose indices with type 2 diabetes compared to general obesity-related indices in community-dwelling Chinese adults: a cross-sectional studyXiaoting Lu0Shanshan Chen1Cheng Wang2Diaozhu Lin3Fengyi He4Xiuhong Lin5Hongshi Wu6Ping Liang7Li Yan8Meng Ren9Chaogang Chen10Department of Clinical Nutrition, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Clinical Nutrition, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Clinical Nutrition, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Clinical Nutrition, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Clinical Nutrition, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Clinical Nutrition, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaObjectivesThe relationships between the triglyceride-glucose (TyG) index, TyG-related parameters of different obesity phenotypes and the risk of type 2 diabetes (T2D) remain unclear. We aimed to determine associations between TyG index, obesity-related TyG parameters and T2D risk in Chinese adults.MethodsThis cross-sectional study included 9489 participants aged ≥40 years from a large scale, community-based cohort study. Multivariable logistic regression was performed to estimate odds ratios (ORs) and 95% confidence intervals (CIs). The receiver operating characteristic (ROC) curve was employed to test and compare the predictive power of obesity-related TyG parameters across different phenotypes for the risk of T2D.ResultsA total of 2081 (21.9%) participants with T2D were identified. When comparing with participants in the bottom quartile of TyG index, a heightened risk of T2D was observed among the highest quartile group, with an adjusted OR of 5.89 (95% CI: 4.98–6.98). Comparable relationships were found between obesity-related TyG indices and T2D, including TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), TyG-body mass index (TyG-BMI) and TyG-body fat percentage (TyG-BFP). Abdominal obesity-related TyG indices had the highest predictive capability for T2D, with the area under the curve (AUC) was 0.711 (0.697–0.724) for TyG-WHtR and 0.705 (0.691–0.719) for TyG-WC, which was superior to the general obesity-related TyG indices, with the AUC were 0.683 (0.669–0.698) and 0.631 (0.616–0.646) for TyG-BMI and TyG-BFP, respectively.ConclusionsOur findings demonstrate a positive associations between TyG index, obesity-related TyG indices and risk of T2D. Abdominal obesity-related TyG indices had a better predictive value to diabetes than general obesity-related TyG indices.https://www.frontiersin.org/articles/10.3389/fendo.2025.1526849/fulltriglyceride-glucose indexobesity-related TyG indicestype 2 diabetesabdominal obesitymiddle-aged and older Chinese adultscross-sectional study |
| spellingShingle | Xiaoting Lu Shanshan Chen Cheng Wang Diaozhu Lin Fengyi He Xiuhong Lin Hongshi Wu Ping Liang Li Yan Meng Ren Chaogang Chen Stronger associations of abdominal obesity-related triglyceride-glucose indices with type 2 diabetes compared to general obesity-related indices in community-dwelling Chinese adults: a cross-sectional study Frontiers in Endocrinology triglyceride-glucose index obesity-related TyG indices type 2 diabetes abdominal obesity middle-aged and older Chinese adults cross-sectional study |
| title | Stronger associations of abdominal obesity-related triglyceride-glucose indices with type 2 diabetes compared to general obesity-related indices in community-dwelling Chinese adults: a cross-sectional study |
| title_full | Stronger associations of abdominal obesity-related triglyceride-glucose indices with type 2 diabetes compared to general obesity-related indices in community-dwelling Chinese adults: a cross-sectional study |
| title_fullStr | Stronger associations of abdominal obesity-related triglyceride-glucose indices with type 2 diabetes compared to general obesity-related indices in community-dwelling Chinese adults: a cross-sectional study |
| title_full_unstemmed | Stronger associations of abdominal obesity-related triglyceride-glucose indices with type 2 diabetes compared to general obesity-related indices in community-dwelling Chinese adults: a cross-sectional study |
| title_short | Stronger associations of abdominal obesity-related triglyceride-glucose indices with type 2 diabetes compared to general obesity-related indices in community-dwelling Chinese adults: a cross-sectional study |
| title_sort | stronger associations of abdominal obesity related triglyceride glucose indices with type 2 diabetes compared to general obesity related indices in community dwelling chinese adults a cross sectional study |
| topic | triglyceride-glucose index obesity-related TyG indices type 2 diabetes abdominal obesity middle-aged and older Chinese adults cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1526849/full |
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