A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study
Introduction and Objectives. Lichen sclerosus (LSc) is a chronic inflammatory process of the skin characterized by its unique histological features. It affects men and women of all ages, mainly in the anogenital area. The etiologies and exact pathophysiology are not well-known; however, LSc can be c...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2023/7208312 |
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| author | Joey El Khoury Jessica Andraos Anthony Kanbar Rami Halabi Serge Assaf Anthony Mina Sabine El Breidi Charbel Dabal Charbel El Hachem Rodrigue Saad Antoine Kassis Maher Abdessater Raghid El Khoury |
| author_facet | Joey El Khoury Jessica Andraos Anthony Kanbar Rami Halabi Serge Assaf Anthony Mina Sabine El Breidi Charbel Dabal Charbel El Hachem Rodrigue Saad Antoine Kassis Maher Abdessater Raghid El Khoury |
| author_sort | Joey El Khoury |
| collection | DOAJ |
| description | Introduction and Objectives. Lichen sclerosus (LSc) is a chronic inflammatory process of the skin characterized by its unique histological features. It affects men and women of all ages, mainly in the anogenital area. The etiologies and exact pathophysiology are not well-known; however, LSc can be considered a precursor to male genital squamous cell carcinoma. We aim, through this case-control study, to potentially associate genital LSc with risk factors and certain patient characteristics in Lebanese adult males. Materials and Methods. A nested case-control study design was chosen. Subjects enrolled were adult male patients who had a circumcision between January 2010 and December 2020 at our university hospital, with a confirmed LSc diagnosis on pathology. Cases were matched with controls by age with a ratio of 1 : 1, all of whom were circumcised and had a negative pathology report. Data collection consisted of sociodemographic, behavioral, and past medical and familial history characteristics. Results. A total of 94 patients were enrolled. The mean age was 49.81 (±22.92) in the group of men with LSc. No significant differences in sociodemographic characteristics (age and BMI) were found between the two compared groups. Smoking cannot predict LSc as opposed to alcohol consumption, which we found to be a protective factor against the appearance of LSc (p=0.027). Men with LSc had significantly higher rates of diabetes (p=0.021) and hypertension (p=0.004). No associations were found between LSc and the presenting chief complaints, family history of LSc, and past penile trauma. Conclusion. In this study, we were able to compare multiple variables between 47 circumcised patients diagnosed with LSc and a control group. We found that LSc patients showed higher rates of diabetes and hypertension. A potential protective effect of alcohol consumption is to be explored in future projects with bigger sample sizes and higher statistical powers. |
| format | Article |
| id | doaj-art-cce684fb691c411cbcc9538f81a88fb7 |
| institution | Kabale University |
| issn | 1687-6377 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-cce684fb691c411cbcc9538f81a88fb72025-02-03T06:42:41ZengWileyAdvances in Urology1687-63772023-01-01202310.1155/2023/7208312A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control StudyJoey El Khoury0Jessica Andraos1Anthony Kanbar2Rami Halabi3Serge Assaf4Anthony Mina5Sabine El Breidi6Charbel Dabal7Charbel El Hachem8Rodrigue Saad9Antoine Kassis10Maher Abdessater11Raghid El Khoury12Notre Dame des Secours University Hospital CenterNotre Dame des Secours University Hospital CenterNotre Dame des Secours University Hospital CenterNotre Dame des Secours University Hospital CenterNotre Dame des Secours University Hospital CenterNotre Dame des Secours University Hospital CenterNotre Dame des Secours University Hospital CenterNotre Dame des Secours University Hospital CenterNotre Dame des Secours University Hospital CenterNotre Dame des Secours University Hospital CenterNotre Dame des Secours University Hospital CenterNotre Dame des Secours University Hospital CenterNotre Dame des Secours University Hospital CenterIntroduction and Objectives. Lichen sclerosus (LSc) is a chronic inflammatory process of the skin characterized by its unique histological features. It affects men and women of all ages, mainly in the anogenital area. The etiologies and exact pathophysiology are not well-known; however, LSc can be considered a precursor to male genital squamous cell carcinoma. We aim, through this case-control study, to potentially associate genital LSc with risk factors and certain patient characteristics in Lebanese adult males. Materials and Methods. A nested case-control study design was chosen. Subjects enrolled were adult male patients who had a circumcision between January 2010 and December 2020 at our university hospital, with a confirmed LSc diagnosis on pathology. Cases were matched with controls by age with a ratio of 1 : 1, all of whom were circumcised and had a negative pathology report. Data collection consisted of sociodemographic, behavioral, and past medical and familial history characteristics. Results. A total of 94 patients were enrolled. The mean age was 49.81 (±22.92) in the group of men with LSc. No significant differences in sociodemographic characteristics (age and BMI) were found between the two compared groups. Smoking cannot predict LSc as opposed to alcohol consumption, which we found to be a protective factor against the appearance of LSc (p=0.027). Men with LSc had significantly higher rates of diabetes (p=0.021) and hypertension (p=0.004). No associations were found between LSc and the presenting chief complaints, family history of LSc, and past penile trauma. Conclusion. In this study, we were able to compare multiple variables between 47 circumcised patients diagnosed with LSc and a control group. We found that LSc patients showed higher rates of diabetes and hypertension. A potential protective effect of alcohol consumption is to be explored in future projects with bigger sample sizes and higher statistical powers.http://dx.doi.org/10.1155/2023/7208312 |
| spellingShingle | Joey El Khoury Jessica Andraos Anthony Kanbar Rami Halabi Serge Assaf Anthony Mina Sabine El Breidi Charbel Dabal Charbel El Hachem Rodrigue Saad Antoine Kassis Maher Abdessater Raghid El Khoury A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study Advances in Urology |
| title | A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study |
| title_full | A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study |
| title_fullStr | A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study |
| title_full_unstemmed | A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study |
| title_short | A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study |
| title_sort | potential protective effect of alcohol consumption in male genital lichen sclerosus a case control study |
| url | http://dx.doi.org/10.1155/2023/7208312 |
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