Characterization and antibacterial activity of biogenic iron nanoparticles using Proteus mirabilis
Abstract Background: The green production of iron oxide nanoparticles (FeONPs) due to its numerous biotechnological uses has attracted a lot of attention and clean and eco-friendly approaches in the medical field. Objectives: The objectives of this study are to demonstrate the biogenic creation of F...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Medical Journal of Babylon |
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| Online Access: | https://doi.org/10.4103/MJBL.MJBL_27_23 |
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| author | Mais Emad Ahmed Huda Mohammed Hasan Anfal Jabbar Kttafah |
| author_facet | Mais Emad Ahmed Huda Mohammed Hasan Anfal Jabbar Kttafah |
| author_sort | Mais Emad Ahmed |
| collection | DOAJ |
| description | Abstract Background: The green production of iron oxide nanoparticles (FeONPs) due to its numerous biotechnological uses has attracted a lot of attention and clean and eco-friendly approaches in the medical field. Objectives: The objectives of this study are to demonstrate the biogenic creation of FeONPs. The search for alternative antimicrobial medicines has been prompted by growing worries about multidrug resistance. Materials and Methods: The purpose of this work was to investigate if Proteus mirabilis was the source of green-manufactured iron nanoparticles (INPs). The Fourier transform infrared, attenuated total reflectance, scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray spectroscopy, ultraviolet–visible, and dynamic light scattering measurements were used to characterize the green synthesized nanoparticles (NPs). Using the agar-well diffusion method, the antibacterial investigation’s efficacy was evaluated. Results: The results found that at 128 μg/mL minimum inhibitory concentration, we have demonstrated the potent antibacterial properties of FeONPs produced through biological procedures against Gram-positive and Gram-negative bacteria that are resistant to many drugs. These NPs, including their antimicrobial qualities, how they work, how they affect drug-resistant microbes, the risks involved with using them, the unique qualities of NPs, their mode of action as antibacterial properties, and the elements that influence how well they function in a therapeutic setting all are thoroughly investigated. Conclusion: Further research on biogenic INPs was necessary to enhance their nanopharmacological importance for biological applications, as they have demonstrated promising biomedical capabilities were successfully synthesized in a friendly environment with few costs, and the highly INPs product showed exceptional activity against bacterial strains. |
| format | Article |
| id | doaj-art-cce33a606ddf4abcbfe717818764f776 |
| institution | Kabale University |
| issn | 1812-156X 2312-6760 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj-art-cce33a606ddf4abcbfe717818764f7762025-01-25T10:14:50ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602024-01-01211394510.4103/MJBL.MJBL_27_23Characterization and antibacterial activity of biogenic iron nanoparticles using Proteus mirabilisMais Emad AhmedHuda Mohammed HasanAnfal Jabbar KttafahAbstract Background: The green production of iron oxide nanoparticles (FeONPs) due to its numerous biotechnological uses has attracted a lot of attention and clean and eco-friendly approaches in the medical field. Objectives: The objectives of this study are to demonstrate the biogenic creation of FeONPs. The search for alternative antimicrobial medicines has been prompted by growing worries about multidrug resistance. Materials and Methods: The purpose of this work was to investigate if Proteus mirabilis was the source of green-manufactured iron nanoparticles (INPs). The Fourier transform infrared, attenuated total reflectance, scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray spectroscopy, ultraviolet–visible, and dynamic light scattering measurements were used to characterize the green synthesized nanoparticles (NPs). Using the agar-well diffusion method, the antibacterial investigation’s efficacy was evaluated. Results: The results found that at 128 μg/mL minimum inhibitory concentration, we have demonstrated the potent antibacterial properties of FeONPs produced through biological procedures against Gram-positive and Gram-negative bacteria that are resistant to many drugs. These NPs, including their antimicrobial qualities, how they work, how they affect drug-resistant microbes, the risks involved with using them, the unique qualities of NPs, their mode of action as antibacterial properties, and the elements that influence how well they function in a therapeutic setting all are thoroughly investigated. Conclusion: Further research on biogenic INPs was necessary to enhance their nanopharmacological importance for biological applications, as they have demonstrated promising biomedical capabilities were successfully synthesized in a friendly environment with few costs, and the highly INPs product showed exceptional activity against bacterial strains.https://doi.org/10.4103/MJBL.MJBL_27_23antibacterial activitycharacterizationiron nanoparticlesproteus mirabilis |
| spellingShingle | Mais Emad Ahmed Huda Mohammed Hasan Anfal Jabbar Kttafah Characterization and antibacterial activity of biogenic iron nanoparticles using Proteus mirabilis Medical Journal of Babylon antibacterial activity characterization iron nanoparticles proteus mirabilis |
| title | Characterization and antibacterial activity of biogenic iron nanoparticles using Proteus mirabilis |
| title_full | Characterization and antibacterial activity of biogenic iron nanoparticles using Proteus mirabilis |
| title_fullStr | Characterization and antibacterial activity of biogenic iron nanoparticles using Proteus mirabilis |
| title_full_unstemmed | Characterization and antibacterial activity of biogenic iron nanoparticles using Proteus mirabilis |
| title_short | Characterization and antibacterial activity of biogenic iron nanoparticles using Proteus mirabilis |
| title_sort | characterization and antibacterial activity of biogenic iron nanoparticles using proteus mirabilis |
| topic | antibacterial activity characterization iron nanoparticles proteus mirabilis |
| url | https://doi.org/10.4103/MJBL.MJBL_27_23 |
| work_keys_str_mv | AT maisemadahmed characterizationandantibacterialactivityofbiogenicironnanoparticlesusingproteusmirabilis AT hudamohammedhasan characterizationandantibacterialactivityofbiogenicironnanoparticlesusingproteusmirabilis AT anfaljabbarkttafah characterizationandantibacterialactivityofbiogenicironnanoparticlesusingproteusmirabilis |