A comprehensive dataset for understanding immune dynamics in colorectal cancer(Mendeley Data).
Colorectal cancer (CRC), the second most common cause of cancer death in the world, can be divided by the location of the primary tumor in the large intestine: right and left colon, and rectum. Based on the location, CRC shows different molecular characteristics, incidence, pathogenesis, and outcome...
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| Language: | English |
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Elsevier
2025-08-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S235234092500544X |
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| author | Zahra Mokhtari Elham Amjadi Hamidreza Bolhasani Zahra Faghih Amirreza Dehghanian Marzieh Rezaei |
| author_facet | Zahra Mokhtari Elham Amjadi Hamidreza Bolhasani Zahra Faghih Amirreza Dehghanian Marzieh Rezaei |
| author_sort | Zahra Mokhtari |
| collection | DOAJ |
| description | Colorectal cancer (CRC), the second most common cause of cancer death in the world, can be divided by the location of the primary tumor in the large intestine: right and left colon, and rectum. Based on the location, CRC shows different molecular characteristics, incidence, pathogenesis, and outcome. Considering the importance of immune components in tumor development, analysis of their interactive relationships with tumor cells in the tumor microenvironment (TME) has received more attention. In addition, routine prognosis systems such as TNM classification have low power to predict the clinical outcome of the disease. Accordingly, the identification of immune-related markers in TME might help to predict the prognosis and clinical outcome of the disease. This research aimed to provide a well-organized histopathological microscopy image dataset for best-scoring CRC. The images were taken from tumor tissue sections of patients with CRC, immunohistochemically stained with antibodies specific for CD3, CD8, CD45RO, PD-1, LAG-3, and Tim3. The markers were separately determined in the tumor's invasive margin and center. The dataset is named CRC-ICM and contains 1,756 images from 136 patients with CRC. It also contains comprehensive information on the clinicopathological characteristics of the patients, with a special focus on the tumor side (right and left). It includes an Excel file describing the patient’s demographic, anatomical features, and histopathological grade. The initial version of CRC-ICM is published on the Elsevier Mendeley dataset portal, and the latest version is accessible at: https://databiox.com. |
| format | Article |
| id | doaj-art-cce22ac481da4f6bbe00db4c563524a0 |
| institution | Kabale University |
| issn | 2352-3409 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj-art-cce22ac481da4f6bbe00db4c563524a02025-08-20T03:42:53ZengElsevierData in Brief2352-34092025-08-016111181710.1016/j.dib.2025.111817A comprehensive dataset for understanding immune dynamics in colorectal cancer(Mendeley Data).Zahra Mokhtari0Elham Amjadi1Hamidreza Bolhasani2Zahra Faghih3Amirreza Dehghanian4Marzieh Rezaei5Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranPoursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Computer Engineering, Science and Research Branch, Islamic Azad University, Tehran, IranSchool of Medicine, Institute for Cancer Research (ICR), Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pathology, School of Medicine, Shiraz University of Medical Science, Shiraz, IranDepartment of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Corresponding author.Colorectal cancer (CRC), the second most common cause of cancer death in the world, can be divided by the location of the primary tumor in the large intestine: right and left colon, and rectum. Based on the location, CRC shows different molecular characteristics, incidence, pathogenesis, and outcome. Considering the importance of immune components in tumor development, analysis of their interactive relationships with tumor cells in the tumor microenvironment (TME) has received more attention. In addition, routine prognosis systems such as TNM classification have low power to predict the clinical outcome of the disease. Accordingly, the identification of immune-related markers in TME might help to predict the prognosis and clinical outcome of the disease. This research aimed to provide a well-organized histopathological microscopy image dataset for best-scoring CRC. The images were taken from tumor tissue sections of patients with CRC, immunohistochemically stained with antibodies specific for CD3, CD8, CD45RO, PD-1, LAG-3, and Tim3. The markers were separately determined in the tumor's invasive margin and center. The dataset is named CRC-ICM and contains 1,756 images from 136 patients with CRC. It also contains comprehensive information on the clinicopathological characteristics of the patients, with a special focus on the tumor side (right and left). It includes an Excel file describing the patient’s demographic, anatomical features, and histopathological grade. The initial version of CRC-ICM is published on the Elsevier Mendeley dataset portal, and the latest version is accessible at: https://databiox.com.http://www.sciencedirect.com/science/article/pii/S235234092500544XColorectal cancerImmune markersImmune checkpointsDatasetImmunohistochemistry |
| spellingShingle | Zahra Mokhtari Elham Amjadi Hamidreza Bolhasani Zahra Faghih Amirreza Dehghanian Marzieh Rezaei A comprehensive dataset for understanding immune dynamics in colorectal cancer(Mendeley Data). Data in Brief Colorectal cancer Immune markers Immune checkpoints Dataset Immunohistochemistry |
| title | A comprehensive dataset for understanding immune dynamics in colorectal cancer(Mendeley Data). |
| title_full | A comprehensive dataset for understanding immune dynamics in colorectal cancer(Mendeley Data). |
| title_fullStr | A comprehensive dataset for understanding immune dynamics in colorectal cancer(Mendeley Data). |
| title_full_unstemmed | A comprehensive dataset for understanding immune dynamics in colorectal cancer(Mendeley Data). |
| title_short | A comprehensive dataset for understanding immune dynamics in colorectal cancer(Mendeley Data). |
| title_sort | comprehensive dataset for understanding immune dynamics in colorectal cancer mendeley data |
| topic | Colorectal cancer Immune markers Immune checkpoints Dataset Immunohistochemistry |
| url | http://www.sciencedirect.com/science/article/pii/S235234092500544X |
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