Correlation of neutrophil percentage-to-albumin ratio with lung function in American adults: a population study
Abstract Background Chronic respiratory diseases pose a significant threat to global health, underscoring the urgent need for effective preventative and therapeutic interventions. The neutrophil-to-albumin ratio (NPAR), an emerging biomarker for inflammation and nutritional status, has shown promisi...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-025-03537-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849723069691592704 |
|---|---|
| author | Xiaolin Zhang Fan Bai Haibin Ni Shiyuan Chen Dan Fu Haiyan Ren Bin Hu |
| author_facet | Xiaolin Zhang Fan Bai Haibin Ni Shiyuan Chen Dan Fu Haiyan Ren Bin Hu |
| author_sort | Xiaolin Zhang |
| collection | DOAJ |
| description | Abstract Background Chronic respiratory diseases pose a significant threat to global health, underscoring the urgent need for effective preventative and therapeutic interventions. The neutrophil-to-albumin ratio (NPAR), an emerging biomarker for inflammation and nutritional status, has shown promising associations with respiratory health, necessitating an investigation into its potential for predicting lung function decline. Objective This study aimed to delineate the relationship between the NPAR and pulmonary function within a sample of the American adult population and assess the viability of the NPAR as a prognostic indicator for compromised lung function. Methods With data available from the National Health and Nutrition Examination Survey (NHANES) for the years 2007 to 2012, 10,055 American adults who met the exclusion criteria were included in the current study. Multivariate linear regression, smoothed curve fitting, and subgroup analyses were applied to evaluate the associations observed between the NPAR and lung function indicators. Results Even after accounting for all potential confounding factors, a significant inverse relationship persisted between the NPAR and key lung function indicators, including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and peak expiratory flow rate (PEF). This association remained robust even after potential confounding factors were considered. Subgroup analysis revealed that the negative correlation was more pronounced in certain demographic groups, such as young individuals, males, and current smokers. The study also revealed an “N-shaped” relationship between the NPAR and fractional exhaled nitric oxide (FENO), suggesting that the NPAR may play a role in promoting airway inflammation. Conclusions A significant correlation between the NPAR and the decline in lung function among American adults was revealed in this research, emphasizing the potential clinical relevance of the NPAR as a respiratory health biomarker, as well as the importance of considering systemic inflammation in the management and prevention of respiratory disorders. |
| format | Article |
| id | doaj-art-ccda3ad990594ce59daa07a7e2a8ce59 |
| institution | DOAJ |
| issn | 1471-2466 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj-art-ccda3ad990594ce59daa07a7e2a8ce592025-08-20T03:11:07ZengBMCBMC Pulmonary Medicine1471-24662025-02-0125111110.1186/s12890-025-03537-9Correlation of neutrophil percentage-to-albumin ratio with lung function in American adults: a population studyXiaolin Zhang0Fan Bai1Haibin Ni2Shiyuan Chen3Dan Fu4Haiyan Ren5Bin Hu6Department of Geriatrics, Beilun District People’s Hospital, Beilun Branch of the First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Geriatrics, Beilun District People’s Hospital, Beilun Branch of the First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Geriatrics, Beilun District People’s Hospital, Beilun Branch of the First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Geriatrics, Beilun District People’s Hospital, Beilun Branch of the First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Geriatrics, Beilun District People’s Hospital, Beilun Branch of the First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Geriatrics, Beilun District People’s Hospital, Beilun Branch of the First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Geriatrics, Beilun District People’s Hospital, Beilun Branch of the First Affiliated Hospital, School of Medicine, Zhejiang UniversityAbstract Background Chronic respiratory diseases pose a significant threat to global health, underscoring the urgent need for effective preventative and therapeutic interventions. The neutrophil-to-albumin ratio (NPAR), an emerging biomarker for inflammation and nutritional status, has shown promising associations with respiratory health, necessitating an investigation into its potential for predicting lung function decline. Objective This study aimed to delineate the relationship between the NPAR and pulmonary function within a sample of the American adult population and assess the viability of the NPAR as a prognostic indicator for compromised lung function. Methods With data available from the National Health and Nutrition Examination Survey (NHANES) for the years 2007 to 2012, 10,055 American adults who met the exclusion criteria were included in the current study. Multivariate linear regression, smoothed curve fitting, and subgroup analyses were applied to evaluate the associations observed between the NPAR and lung function indicators. Results Even after accounting for all potential confounding factors, a significant inverse relationship persisted between the NPAR and key lung function indicators, including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and peak expiratory flow rate (PEF). This association remained robust even after potential confounding factors were considered. Subgroup analysis revealed that the negative correlation was more pronounced in certain demographic groups, such as young individuals, males, and current smokers. The study also revealed an “N-shaped” relationship between the NPAR and fractional exhaled nitric oxide (FENO), suggesting that the NPAR may play a role in promoting airway inflammation. Conclusions A significant correlation between the NPAR and the decline in lung function among American adults was revealed in this research, emphasizing the potential clinical relevance of the NPAR as a respiratory health biomarker, as well as the importance of considering systemic inflammation in the management and prevention of respiratory disorders.https://doi.org/10.1186/s12890-025-03537-9NPARLung functionBiomarkerChronic respiratory diseaseRespiratory health |
| spellingShingle | Xiaolin Zhang Fan Bai Haibin Ni Shiyuan Chen Dan Fu Haiyan Ren Bin Hu Correlation of neutrophil percentage-to-albumin ratio with lung function in American adults: a population study BMC Pulmonary Medicine NPAR Lung function Biomarker Chronic respiratory disease Respiratory health |
| title | Correlation of neutrophil percentage-to-albumin ratio with lung function in American adults: a population study |
| title_full | Correlation of neutrophil percentage-to-albumin ratio with lung function in American adults: a population study |
| title_fullStr | Correlation of neutrophil percentage-to-albumin ratio with lung function in American adults: a population study |
| title_full_unstemmed | Correlation of neutrophil percentage-to-albumin ratio with lung function in American adults: a population study |
| title_short | Correlation of neutrophil percentage-to-albumin ratio with lung function in American adults: a population study |
| title_sort | correlation of neutrophil percentage to albumin ratio with lung function in american adults a population study |
| topic | NPAR Lung function Biomarker Chronic respiratory disease Respiratory health |
| url | https://doi.org/10.1186/s12890-025-03537-9 |
| work_keys_str_mv | AT xiaolinzhang correlationofneutrophilpercentagetoalbuminratiowithlungfunctioninamericanadultsapopulationstudy AT fanbai correlationofneutrophilpercentagetoalbuminratiowithlungfunctioninamericanadultsapopulationstudy AT haibinni correlationofneutrophilpercentagetoalbuminratiowithlungfunctioninamericanadultsapopulationstudy AT shiyuanchen correlationofneutrophilpercentagetoalbuminratiowithlungfunctioninamericanadultsapopulationstudy AT danfu correlationofneutrophilpercentagetoalbuminratiowithlungfunctioninamericanadultsapopulationstudy AT haiyanren correlationofneutrophilpercentagetoalbuminratiowithlungfunctioninamericanadultsapopulationstudy AT binhu correlationofneutrophilpercentagetoalbuminratiowithlungfunctioninamericanadultsapopulationstudy |