Impaired nutrient absorption, reduced bone mass and alterations in the gut microbiome contribute to postnatal growth retardation in a mouse model of MWS

Impaired nutrient absorption, reduced bone mass and alterations in the gut microbiome contribute to postnatal growth retardation in a mouse model of MWS

Abstract Mowat‒Wilson syndrome (MWS), a rare genetic disorder caused by heterozygous loss-of-function mutations in ZEB2, is characterised by significant growth retardation with unclear mechanisms. In this study, we developed a Zeb2 haploinsufficient (Zeb2 +/− ) mouse model that recapitulates key fea...

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Bibliographic Details
Main Authors: Yangyang Ge, Lingya Liu, Lihua Wu, Xiaofan Liu, Yingao Hao, Shixu Wang, Yi Xiong, Zi Yang, Zhen Zhang, Qi Li, Bo Li, Jianxin Wu, Guangxu Ren, Qian Jiang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Zeb2
Small intestine
Nutrient absorption
Bone mass
Microbiota
Online Access:https://doi.org/10.1038/s41598-025-16542-z
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