The effects of routine administration of probiotics on the length of central venous line usage in extremely premature infants
The objective of this study was to determine whether the routine use of probiotics was associated with earlier removal of peripherally inserted central catheter (PICC) lines in extremely premature infants born ≤28 weeks' gestation. This study was a retrospective, observational, cohort study in...
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Hacettepe University Institute of Child Health
2017-02-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/943 |
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| author | Nitin Rajput Julia Filipovska Michael Hewson |
| author_facet | Nitin Rajput Julia Filipovska Michael Hewson |
| author_sort | Nitin Rajput |
| collection | DOAJ |
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The objective of this study was to determine whether the routine use of probiotics was associated with earlier removal of peripherally inserted central catheter (PICC) lines in extremely premature infants born ≤28 weeks' gestation. This study was a retrospective, observational, cohort study in infants born ≤28 weeks gestation in the 2 years before [No Probiotic Group (NPG)] and after [Probiotic Group (PG)] the commencement of the routine use of probiotics (lnfloran®) in a large tertiary neonatal intensive care unit in the North Island of New Zealand. Age at the removal of PICC line in patients whose first PICC lines were inserted before day 14 and remained in-situ for at least 4 days was compared using Kaplan-Meir Survival Analysis on SPSS 22.0®. We studied PICC line infections as a secondary outcome measure. We compared 120 PICC lines in NPG and 130 PICC lines in PG. Mean age at removal was 25.9 [(95% Confidence Intervals (CI)=22.6 - 29.2)] days in NPG and 23.1 (95% CI=20.9 - 25.2) days in PG. The result was independent of birth weight, gender, type of PICC line and age at insertion but related significantly to gestation at birth (p < 0.001). There was no difference in the incidence or the microbiologic profile of PICC line infections between the study groups. PICC lines were removed 2.8 days earlier in infants receiving probiotics (p=0.070), which can have potential benefits with reduced infection and other risks due to earlier removal of PICC lines.
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| format | Article |
| id | doaj-art-ccd702d0d6ca442b9d5f610820d3a157 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-ccd702d0d6ca442b9d5f610820d3a1572025-08-20T02:55:41ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212017-02-0159110.24953/turkjped.2017.01.004The effects of routine administration of probiotics on the length of central venous line usage in extremely premature infantsNitin Rajput0Julia Filipovska1Michael Hewson2Neonatal Intensive Care Unit, Wellington Regional Hospital, New Zealand.Deakin University, Ballarat Base Hospital, Australia.Neonatal Intensive Care Unit, Wellington Regional Hospital, New Zealand. The objective of this study was to determine whether the routine use of probiotics was associated with earlier removal of peripherally inserted central catheter (PICC) lines in extremely premature infants born ≤28 weeks' gestation. This study was a retrospective, observational, cohort study in infants born ≤28 weeks gestation in the 2 years before [No Probiotic Group (NPG)] and after [Probiotic Group (PG)] the commencement of the routine use of probiotics (lnfloran®) in a large tertiary neonatal intensive care unit in the North Island of New Zealand. Age at the removal of PICC line in patients whose first PICC lines were inserted before day 14 and remained in-situ for at least 4 days was compared using Kaplan-Meir Survival Analysis on SPSS 22.0®. We studied PICC line infections as a secondary outcome measure. We compared 120 PICC lines in NPG and 130 PICC lines in PG. Mean age at removal was 25.9 [(95% Confidence Intervals (CI)=22.6 - 29.2)] days in NPG and 23.1 (95% CI=20.9 - 25.2) days in PG. The result was independent of birth weight, gender, type of PICC line and age at insertion but related significantly to gestation at birth (p < 0.001). There was no difference in the incidence or the microbiologic profile of PICC line infections between the study groups. PICC lines were removed 2.8 days earlier in infants receiving probiotics (p=0.070), which can have potential benefits with reduced infection and other risks due to earlier removal of PICC lines. https://turkjpediatr.org/article/view/943PICC line removalenteral nutritionnecrotizing enterocolitisprobiotics |
| spellingShingle | Nitin Rajput Julia Filipovska Michael Hewson The effects of routine administration of probiotics on the length of central venous line usage in extremely premature infants The Turkish Journal of Pediatrics PICC line removal enteral nutrition necrotizing enterocolitis probiotics |
| title | The effects of routine administration of probiotics on the length of central venous line usage in extremely premature infants |
| title_full | The effects of routine administration of probiotics on the length of central venous line usage in extremely premature infants |
| title_fullStr | The effects of routine administration of probiotics on the length of central venous line usage in extremely premature infants |
| title_full_unstemmed | The effects of routine administration of probiotics on the length of central venous line usage in extremely premature infants |
| title_short | The effects of routine administration of probiotics on the length of central venous line usage in extremely premature infants |
| title_sort | effects of routine administration of probiotics on the length of central venous line usage in extremely premature infants |
| topic | PICC line removal enteral nutrition necrotizing enterocolitis probiotics |
| url | https://turkjpediatr.org/article/view/943 |
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