Microbiome and Phageome: Key Factors in Host Organism Function and Disease Prevention in the Context of Microbiome Transplants
The study of interactions between gut microbiota and the well-being of the host has become increasingly popular in the last decades. Growing interest in gut microbiota–host interactions has brought attention to faecal microbiota transplantation (FMT) as a clinically effective, though still debated,...
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MDPI AG
2025-05-01
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| Online Access: | https://www.mdpi.com/2076-3417/15/10/5330 |
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| author | Wojciech Jankowski Małgorzata Mizielińska Paweł Nawrotek |
| author_facet | Wojciech Jankowski Małgorzata Mizielińska Paweł Nawrotek |
| author_sort | Wojciech Jankowski |
| collection | DOAJ |
| description | The study of interactions between gut microbiota and the well-being of the host has become increasingly popular in the last decades. Growing interest in gut microbiota–host interactions has brought attention to faecal microbiota transplantation (FMT) as a clinically effective, though still debated, therapeutic approach. This review discusses how limitations in the characterisation of gut bacteriomes—particularly interindividual variation and methodological inconsistencies—may influence the outcomes of FMT. The concept of enterotypes is considered as a framework that could support more refined stratification of donors and recipients, offering a possible route toward greater precision in microbiota-based interventions. Further on, the review touches on the subject of interactions among the host, the bacteriome, and the phageome—the community of bacteriophages—with specific focus on the presence and intriguing distribution patterns of crAssviruses. The final chapters are dedicated to discussing the current state of the FMT procedure and its variations, as well as the possibility of performing faecal virome transplants (FVTs) as a potentially safer and equally efficient alternative. |
| format | Article |
| id | doaj-art-ccd31bd1e0424682a44781a2bff04d3e |
| institution | OA Journals |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-ccd31bd1e0424682a44781a2bff04d3e2025-08-20T01:56:29ZengMDPI AGApplied Sciences2076-34172025-05-011510533010.3390/app15105330Microbiome and Phageome: Key Factors in Host Organism Function and Disease Prevention in the Context of Microbiome TransplantsWojciech Jankowski0Małgorzata Mizielińska1Paweł Nawrotek2Center for Bioimmobilisation and Innovative Packaging Materials, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology in Szczecin, Janickiego 35, 71-270 Szczecin, PolandCenter for Bioimmobilisation and Innovative Packaging Materials, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology in Szczecin, Janickiego 35, 71-270 Szczecin, PolandCenter for Nanotechnology Research and Education, Department of Microbiology and Biotechnology, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology in Szczecin, Piastów Avenue 45, 70-311 Szczecin, PolandThe study of interactions between gut microbiota and the well-being of the host has become increasingly popular in the last decades. Growing interest in gut microbiota–host interactions has brought attention to faecal microbiota transplantation (FMT) as a clinically effective, though still debated, therapeutic approach. This review discusses how limitations in the characterisation of gut bacteriomes—particularly interindividual variation and methodological inconsistencies—may influence the outcomes of FMT. The concept of enterotypes is considered as a framework that could support more refined stratification of donors and recipients, offering a possible route toward greater precision in microbiota-based interventions. Further on, the review touches on the subject of interactions among the host, the bacteriome, and the phageome—the community of bacteriophages—with specific focus on the presence and intriguing distribution patterns of crAssviruses. The final chapters are dedicated to discussing the current state of the FMT procedure and its variations, as well as the possibility of performing faecal virome transplants (FVTs) as a potentially safer and equally efficient alternative.https://www.mdpi.com/2076-3417/15/10/5330gutintestinesenterotypesbacteriaphagescrAssviruses |
| spellingShingle | Wojciech Jankowski Małgorzata Mizielińska Paweł Nawrotek Microbiome and Phageome: Key Factors in Host Organism Function and Disease Prevention in the Context of Microbiome Transplants Applied Sciences gut intestines enterotypes bacteria phages crAssviruses |
| title | Microbiome and Phageome: Key Factors in Host Organism Function and Disease Prevention in the Context of Microbiome Transplants |
| title_full | Microbiome and Phageome: Key Factors in Host Organism Function and Disease Prevention in the Context of Microbiome Transplants |
| title_fullStr | Microbiome and Phageome: Key Factors in Host Organism Function and Disease Prevention in the Context of Microbiome Transplants |
| title_full_unstemmed | Microbiome and Phageome: Key Factors in Host Organism Function and Disease Prevention in the Context of Microbiome Transplants |
| title_short | Microbiome and Phageome: Key Factors in Host Organism Function and Disease Prevention in the Context of Microbiome Transplants |
| title_sort | microbiome and phageome key factors in host organism function and disease prevention in the context of microbiome transplants |
| topic | gut intestines enterotypes bacteria phages crAssviruses |
| url | https://www.mdpi.com/2076-3417/15/10/5330 |
| work_keys_str_mv | AT wojciechjankowski microbiomeandphageomekeyfactorsinhostorganismfunctionanddiseasepreventioninthecontextofmicrobiometransplants AT małgorzatamizielinska microbiomeandphageomekeyfactorsinhostorganismfunctionanddiseasepreventioninthecontextofmicrobiometransplants AT pawełnawrotek microbiomeandphageomekeyfactorsinhostorganismfunctionanddiseasepreventioninthecontextofmicrobiometransplants |