Low levels of DNA repair enzyme NEIL2 May exacerbate inflammation and genomic damage in subjects with stable COPD and during severe exacerbations

Low levels of DNA repair enzyme NEIL2 May exacerbate inflammation and genomic damage in subjects with stable COPD and during severe exacerbations

Abstract Background Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease that is an independent risk factor for lung cancer. Reduction in NEIL2 function, a DNA glycosylase involved in DNA repair during transcription, has been associated with an increased incidence of...

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Bibliographic Details
Main Authors: Victor J. Cardenas Jr., Justin B. Seashore, Nisha Tapryal, Moe Ameri, Rosalinda Rivera, Kabir Sharma, Tapas Hazra
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Respiratory Research
Subjects:
DNA repair
COPD
Cancer
Genomic damage
Airway inflammation
Eosinophils
Online Access:https://doi.org/10.1186/s12931-025-03251-4
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