Lipidomics-based natural products for chronic kidney disease treatment
Chronic kidney disease (CKD) is by far the most prevalent disease in the world and is now a major global public health problem because of the increase in diabetes, hypertension and obesity. Traditional biomarkers of kidney function lack sensitivity and specificity for early detection and monitoring...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024176517 |
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| author | Rui Zhang Jingjing Wang Chenguang Wu Lifan Wang Peng Liu Ping Li |
| author_facet | Rui Zhang Jingjing Wang Chenguang Wu Lifan Wang Peng Liu Ping Li |
| author_sort | Rui Zhang |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is by far the most prevalent disease in the world and is now a major global public health problem because of the increase in diabetes, hypertension and obesity. Traditional biomarkers of kidney function lack sensitivity and specificity for early detection and monitoring of CKD progression, necessitating more sensitive biomarkers for early diagnostic intervention. Dyslipidemia is a hallmark of CKD. Advancements in mass spectrometry (MS)-based lipidomics platforms have facilitated comprehensive analysis of lipids in biological samples and have revealed changes in the lipidome that are associated with metabolic disorders, which can be used as new biomarkers for kidney diseases. It is also critical for the discovery of new therapeutic targets and drugs. In this article, we focus on lipids in CKD, lipidomics methodologies and their applications in CKD. Additionally, we introduce novel biomarkers identified through lipidomics approaches and natural products derived from lipidomics for the treatment of CKD. We believe that our study makes a significant contribution to literature by demonstrating that natural products can improve CKD from a lipidomic perspective. |
| format | Article |
| id | doaj-art-cccb6478256c421baa9f7682df9698d6 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-cccb6478256c421baa9f7682df9698d62025-01-17T04:51:45ZengElsevierHeliyon2405-84402025-01-01111e41620Lipidomics-based natural products for chronic kidney disease treatmentRui Zhang0Jingjing Wang1Chenguang Wu2Lifan Wang3Peng Liu4Ping Li5Renal Division, Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, ChinaRenal Division, Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, ChinaRenal Division, Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, ChinaRenal Division, Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, China; Corresponding author. No. 142, Sanfu Street, Harbin, 150036, China.Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, China; Corresponding author. No.1 Courtyard Jiansheng Street, Shunyi District, Beijing, China.Beijing Key Lab for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Beijing, China; Corresponding author. No. 2 Yinghua Dongjie, Beijing, 100029, China.Chronic kidney disease (CKD) is by far the most prevalent disease in the world and is now a major global public health problem because of the increase in diabetes, hypertension and obesity. Traditional biomarkers of kidney function lack sensitivity and specificity for early detection and monitoring of CKD progression, necessitating more sensitive biomarkers for early diagnostic intervention. Dyslipidemia is a hallmark of CKD. Advancements in mass spectrometry (MS)-based lipidomics platforms have facilitated comprehensive analysis of lipids in biological samples and have revealed changes in the lipidome that are associated with metabolic disorders, which can be used as new biomarkers for kidney diseases. It is also critical for the discovery of new therapeutic targets and drugs. In this article, we focus on lipids in CKD, lipidomics methodologies and their applications in CKD. Additionally, we introduce novel biomarkers identified through lipidomics approaches and natural products derived from lipidomics for the treatment of CKD. We believe that our study makes a significant contribution to literature by demonstrating that natural products can improve CKD from a lipidomic perspective.http://www.sciencedirect.com/science/article/pii/S2405844024176517Chronic kidney diseaseLipidsLipidomicsTherapeutic targetsNatural products |
| spellingShingle | Rui Zhang Jingjing Wang Chenguang Wu Lifan Wang Peng Liu Ping Li Lipidomics-based natural products for chronic kidney disease treatment Heliyon Chronic kidney disease Lipids Lipidomics Therapeutic targets Natural products |
| title | Lipidomics-based natural products for chronic kidney disease treatment |
| title_full | Lipidomics-based natural products for chronic kidney disease treatment |
| title_fullStr | Lipidomics-based natural products for chronic kidney disease treatment |
| title_full_unstemmed | Lipidomics-based natural products for chronic kidney disease treatment |
| title_short | Lipidomics-based natural products for chronic kidney disease treatment |
| title_sort | lipidomics based natural products for chronic kidney disease treatment |
| topic | Chronic kidney disease Lipids Lipidomics Therapeutic targets Natural products |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024176517 |
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