Effects of a single application of hydrolyzed fish collagen on dermal protein expression and tissue architecture in human skin models
Abstract The use of collagen as an active ingredient in cosmetic products is becoming increasingly common. Recently, scientific interest has been focused on fish collagen, which is similar to human collagen and can be extracted from fish by-products. This study evaluates the cosmetic potential of Hy...
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-11372-5 |
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| author | Lorenzo Dondero Giulia De Negri Atanasio Erica Lertora Francesca Tardanico Ilaria Demori Pietro Storace Giorgia Allaria Francesca Rispo Federica Robino Elisabetta Perata Matteo Zanotti-Russo Sara Ferrando Elena Grasselli |
| author_facet | Lorenzo Dondero Giulia De Negri Atanasio Erica Lertora Francesca Tardanico Ilaria Demori Pietro Storace Giorgia Allaria Francesca Rispo Federica Robino Elisabetta Perata Matteo Zanotti-Russo Sara Ferrando Elena Grasselli |
| author_sort | Lorenzo Dondero |
| collection | DOAJ |
| description | Abstract The use of collagen as an active ingredient in cosmetic products is becoming increasingly common. Recently, scientific interest has been focused on fish collagen, which is similar to human collagen and can be extracted from fish by-products. This study evaluates the cosmetic potential of Hydrolyzed Fish Collagen (HFC), testing it both as an aqueous solution (S-HFC) and as a formulation in cosmetic products (F-HFC) containing the same amount of HFC. The effects of S-HFC and F-HFC were evaluated on 2D (endothelial and keratinocyte cells) and 3D (EpiDerm and EpiDerm-FT) skin models. The results demonstrated that HFC, as an active ingredient, shows promising effects on skin physiology, including increased cell viability, enhanced wound healing, and an anti-wrinkle effect. |
| format | Article |
| id | doaj-art-ccca3817ac694056bafe385ebba7b1bb |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-ccca3817ac694056bafe385ebba7b1bb2025-08-20T03:45:48ZengNature PortfolioScientific Reports2045-23222025-08-0115111310.1038/s41598-025-11372-5Effects of a single application of hydrolyzed fish collagen on dermal protein expression and tissue architecture in human skin modelsLorenzo Dondero0Giulia De Negri Atanasio1Erica Lertora2Francesca Tardanico3Ilaria Demori4Pietro Storace5Giorgia Allaria6Francesca Rispo7Federica Robino8Elisabetta Perata9Matteo Zanotti-Russo10Sara Ferrando11Elena Grasselli12Department of Earth, Environment and Life Science, University of GenoaDepartment of Earth, Environment and Life Science, University of GenoaDepartment of Earth, Environment and Life Science, University of GenoaDepartment of Earth, Environment and Life Science, University of GenoaDepartment of Pharmacy, University of GenoaDepartment of Earth, Environment and Life Science, University of GenoaDepartment of Earth, Environment and Life Science, University of GenoaDepartment of Earth, Environment and Life Science, University of GenoaDepartment of Earth, Environment and Life Science, University of GenoaDepartment of Earth, Environment and Life Science, University of GenoaAngel ConsultingDepartment of Earth, Environment and Life Science, University of GenoaDepartment of Earth, Environment and Life Science, University of GenoaAbstract The use of collagen as an active ingredient in cosmetic products is becoming increasingly common. Recently, scientific interest has been focused on fish collagen, which is similar to human collagen and can be extracted from fish by-products. This study evaluates the cosmetic potential of Hydrolyzed Fish Collagen (HFC), testing it both as an aqueous solution (S-HFC) and as a formulation in cosmetic products (F-HFC) containing the same amount of HFC. The effects of S-HFC and F-HFC were evaluated on 2D (endothelial and keratinocyte cells) and 3D (EpiDerm and EpiDerm-FT) skin models. The results demonstrated that HFC, as an active ingredient, shows promising effects on skin physiology, including increased cell viability, enhanced wound healing, and an anti-wrinkle effect.https://doi.org/10.1038/s41598-025-11372-5Hydrolyzed fish collagenCircular economySkin ageingNew approach methodologiesNext generation risk assessment |
| spellingShingle | Lorenzo Dondero Giulia De Negri Atanasio Erica Lertora Francesca Tardanico Ilaria Demori Pietro Storace Giorgia Allaria Francesca Rispo Federica Robino Elisabetta Perata Matteo Zanotti-Russo Sara Ferrando Elena Grasselli Effects of a single application of hydrolyzed fish collagen on dermal protein expression and tissue architecture in human skin models Scientific Reports Hydrolyzed fish collagen Circular economy Skin ageing New approach methodologies Next generation risk assessment |
| title | Effects of a single application of hydrolyzed fish collagen on dermal protein expression and tissue architecture in human skin models |
| title_full | Effects of a single application of hydrolyzed fish collagen on dermal protein expression and tissue architecture in human skin models |
| title_fullStr | Effects of a single application of hydrolyzed fish collagen on dermal protein expression and tissue architecture in human skin models |
| title_full_unstemmed | Effects of a single application of hydrolyzed fish collagen on dermal protein expression and tissue architecture in human skin models |
| title_short | Effects of a single application of hydrolyzed fish collagen on dermal protein expression and tissue architecture in human skin models |
| title_sort | effects of a single application of hydrolyzed fish collagen on dermal protein expression and tissue architecture in human skin models |
| topic | Hydrolyzed fish collagen Circular economy Skin ageing New approach methodologies Next generation risk assessment |
| url | https://doi.org/10.1038/s41598-025-11372-5 |
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