Personalized Human Astrocyte‐Derived Region‐Specific Forebrain Organoids Recapitulate Endogenous Pathological Features of Focal Cortical Dysplasia

Personalized Human Astrocyte‐Derived Region‐Specific Forebrain Organoids Recapitulate Endogenous Pathological Features of Focal Cortical Dysplasia

Abstract Focal cortical dysplasia (FCD) is a highly heterogeneous neurodevelopmental malformation, the underlying mechanisms of which remain largely elusive. In this study, personalized dorsal and ventral forebrain organoids (DFOs/VFOs) are generated derived from brain astrocytes of patients with FC...

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Main Authors: Jinhong Xu, Yufei Kong, Nawen Wang, Huijuan Li, Yunteng Li, Zhuo Liu, Yuling Yang, Xiao Yu, Huihui Liu, Jing Ding, Yi Wang, Rui Zhao, Zhicheng Shao
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
disease modeling
focal cortical dysplasia
forebrain organoids
human astrocyte
induced pluripotent stem cells
Online Access:https://doi.org/10.1002/advs.202409774
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