Isolation, Synthesis, and Fungicidal Activity of Isopropyl (3-methyl-1-oxo-1-((1-((4-(prop-2-yn-1-yloxy)phenyl)thio)propan-2-yl)amino)butan-2-yl)carbamate Diastereomers against Phytophthora capsici
Two isopropyl (3-methyl-1-oxo-1-((1-((4-(prop-2-yn-1-yloxy)phenyl)thio)propan-2-yl)amino)butan-2-yl)carbamate diastereomers were isolated. Fungicidal activities indicated that the isolated four chiral compounds possessed excellent activity against P. capsici with the EC50 value of 4a (1.30 μg/mL), 4...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Heteroatom Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2022/4678338 |
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| author | Lei Tian Yang Gao Xing-Jie Peng Cheng Zhang Wei-Guang Zhao Xing-Hai Liu |
| author_facet | Lei Tian Yang Gao Xing-Jie Peng Cheng Zhang Wei-Guang Zhao Xing-Hai Liu |
| author_sort | Lei Tian |
| collection | DOAJ |
| description | Two isopropyl (3-methyl-1-oxo-1-((1-((4-(prop-2-yn-1-yloxy)phenyl)thio)propan-2-yl)amino)butan-2-yl)carbamate diastereomers were isolated. Fungicidal activities indicated that the isolated four chiral compounds possessed excellent activity against P. capsici with the EC50 value of 4a (1.30 μg/mL), 4b (0.078 μg/mL), 4c (1.85 μg/mL), and 4d (44.4 μg/mL). Among them, compound 4b exhibited remarkably high activities against Phytophthora capsici, which is better than that of positive control dimethomorph. Its R and S isomers showed that chiral influences the activity against P. capsici. |
| format | Article |
| id | doaj-art-ccc0aabe4f914a1db3e910e3519bcdf7 |
| institution | OA Journals |
| issn | 1098-1071 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Heteroatom Chemistry |
| spelling | doaj-art-ccc0aabe4f914a1db3e910e3519bcdf72025-08-20T02:19:57ZengWileyHeteroatom Chemistry1098-10712022-01-01202210.1155/2022/4678338Isolation, Synthesis, and Fungicidal Activity of Isopropyl (3-methyl-1-oxo-1-((1-((4-(prop-2-yn-1-yloxy)phenyl)thio)propan-2-yl)amino)butan-2-yl)carbamate Diastereomers against Phytophthora capsiciLei Tian0Yang Gao1Xing-Jie Peng2Cheng Zhang3Wei-Guang Zhao4Xing-Hai Liu5State Key Laboratory of Elemental Organic ChemistryState Key Laboratory of Elemental Organic ChemistryState Key Laboratory of Elemental Organic ChemistryState Key Laboratory of Elemental Organic ChemistryState Key Laboratory of Elemental Organic ChemistryCollege of Chemical EngineeringTwo isopropyl (3-methyl-1-oxo-1-((1-((4-(prop-2-yn-1-yloxy)phenyl)thio)propan-2-yl)amino)butan-2-yl)carbamate diastereomers were isolated. Fungicidal activities indicated that the isolated four chiral compounds possessed excellent activity against P. capsici with the EC50 value of 4a (1.30 μg/mL), 4b (0.078 μg/mL), 4c (1.85 μg/mL), and 4d (44.4 μg/mL). Among them, compound 4b exhibited remarkably high activities against Phytophthora capsici, which is better than that of positive control dimethomorph. Its R and S isomers showed that chiral influences the activity against P. capsici.http://dx.doi.org/10.1155/2022/4678338 |
| spellingShingle | Lei Tian Yang Gao Xing-Jie Peng Cheng Zhang Wei-Guang Zhao Xing-Hai Liu Isolation, Synthesis, and Fungicidal Activity of Isopropyl (3-methyl-1-oxo-1-((1-((4-(prop-2-yn-1-yloxy)phenyl)thio)propan-2-yl)amino)butan-2-yl)carbamate Diastereomers against Phytophthora capsici Heteroatom Chemistry |
| title | Isolation, Synthesis, and Fungicidal Activity of Isopropyl (3-methyl-1-oxo-1-((1-((4-(prop-2-yn-1-yloxy)phenyl)thio)propan-2-yl)amino)butan-2-yl)carbamate Diastereomers against Phytophthora capsici |
| title_full | Isolation, Synthesis, and Fungicidal Activity of Isopropyl (3-methyl-1-oxo-1-((1-((4-(prop-2-yn-1-yloxy)phenyl)thio)propan-2-yl)amino)butan-2-yl)carbamate Diastereomers against Phytophthora capsici |
| title_fullStr | Isolation, Synthesis, and Fungicidal Activity of Isopropyl (3-methyl-1-oxo-1-((1-((4-(prop-2-yn-1-yloxy)phenyl)thio)propan-2-yl)amino)butan-2-yl)carbamate Diastereomers against Phytophthora capsici |
| title_full_unstemmed | Isolation, Synthesis, and Fungicidal Activity of Isopropyl (3-methyl-1-oxo-1-((1-((4-(prop-2-yn-1-yloxy)phenyl)thio)propan-2-yl)amino)butan-2-yl)carbamate Diastereomers against Phytophthora capsici |
| title_short | Isolation, Synthesis, and Fungicidal Activity of Isopropyl (3-methyl-1-oxo-1-((1-((4-(prop-2-yn-1-yloxy)phenyl)thio)propan-2-yl)amino)butan-2-yl)carbamate Diastereomers against Phytophthora capsici |
| title_sort | isolation synthesis and fungicidal activity of isopropyl 3 methyl 1 oxo 1 1 4 prop 2 yn 1 yloxy phenyl thio propan 2 yl amino butan 2 yl carbamate diastereomers against phytophthora capsici |
| url | http://dx.doi.org/10.1155/2022/4678338 |
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