Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation
Artemisia princeps var. orientalis (Asteraceae, A. princeps) is a well-known traditional medicinal herb used for treating various inflammatory disorders in Korea, Japan, China, and other Asian countries. In the present study, we investigated the effects of A. princeps extract (APO) on interleukin- (...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/6054069 |
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| author | Su-Bin Kwak Sushruta Koppula Eun-Jung In Xiao Sun Young-Kyu Kim Myong-Ki Kim Kwang-Ho Lee Tae-Bong Kang |
| author_facet | Su-Bin Kwak Sushruta Koppula Eun-Jung In Xiao Sun Young-Kyu Kim Myong-Ki Kim Kwang-Ho Lee Tae-Bong Kang |
| author_sort | Su-Bin Kwak |
| collection | DOAJ |
| description | Artemisia princeps var. orientalis (Asteraceae, A. princeps) is a well-known traditional medicinal herb used for treating various inflammatory disorders in Korea, Japan, China, and other Asian countries. In the present study, we investigated the effects of A. princeps extract (APO) on interleukin- (IL-) 1β regulation and inflammasome activation in bone marrow-derived macrophages (BMDMs) and monosodium urate- (MSU-) induced peritonitis mouse model in vivo. The APO treatment to BMDMs primed with lipopolysaccharide (LPS) attenuated the NLRP3 and AIM2 inflammasome activation induced by danger signals, such as ATP, nigericin, silica crystals, and poly (dA:dT), respectively. Mechanistic study revealed that APO suppressed the ASC oligomerization and speck formation, which are required for inflammasome activation. APO treatment also reduced the ASC phosphorylation induced by the combination of LPS and a tyrosine phosphatase inhibitor. In vivo evaluation revealed that intraperitoneal administration of APO reduced IL-1β levels, significantly (p<0.05) and dose dependently, in the MSU-induced peritonitis mouse model. In conclusion, our study is the first to report that the extract of A. princeps inhibits inflammasome activation through the modulation of ASC phosphorylation. Therefore, APO might be developed as therapeutic potential in the treatment of inflammasome-mediated inflammatory disorders, such as gouty arthritis. |
| format | Article |
| id | doaj-art-ccbc4a038f9746b88c0e34f2c30174b6 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ccbc4a038f9746b88c0e34f2c30174b62025-08-20T02:19:58ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/60540696054069Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC PhosphorylationSu-Bin Kwak0Sushruta Koppula1Eun-Jung In2Xiao Sun3Young-Kyu Kim4Myong-Ki Kim5Kwang-Ho Lee6Tae-Bong Kang7Department of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of KoreaDepartment of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of KoreaDepartment of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of KoreaDepartment of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of KoreaDepartment of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of KoreaDepartment of Food Science and Engineering, Seowon University, Cheongju, Republic of KoreaDepartment of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of KoreaDepartment of Applied Life Science, Graduate School, Konkuk University, Chungju, Republic of KoreaArtemisia princeps var. orientalis (Asteraceae, A. princeps) is a well-known traditional medicinal herb used for treating various inflammatory disorders in Korea, Japan, China, and other Asian countries. In the present study, we investigated the effects of A. princeps extract (APO) on interleukin- (IL-) 1β regulation and inflammasome activation in bone marrow-derived macrophages (BMDMs) and monosodium urate- (MSU-) induced peritonitis mouse model in vivo. The APO treatment to BMDMs primed with lipopolysaccharide (LPS) attenuated the NLRP3 and AIM2 inflammasome activation induced by danger signals, such as ATP, nigericin, silica crystals, and poly (dA:dT), respectively. Mechanistic study revealed that APO suppressed the ASC oligomerization and speck formation, which are required for inflammasome activation. APO treatment also reduced the ASC phosphorylation induced by the combination of LPS and a tyrosine phosphatase inhibitor. In vivo evaluation revealed that intraperitoneal administration of APO reduced IL-1β levels, significantly (p<0.05) and dose dependently, in the MSU-induced peritonitis mouse model. In conclusion, our study is the first to report that the extract of A. princeps inhibits inflammasome activation through the modulation of ASC phosphorylation. Therefore, APO might be developed as therapeutic potential in the treatment of inflammasome-mediated inflammatory disorders, such as gouty arthritis.http://dx.doi.org/10.1155/2018/6054069 |
| spellingShingle | Su-Bin Kwak Sushruta Koppula Eun-Jung In Xiao Sun Young-Kyu Kim Myong-Ki Kim Kwang-Ho Lee Tae-Bong Kang Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation Mediators of Inflammation |
| title | Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation |
| title_full | Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation |
| title_fullStr | Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation |
| title_full_unstemmed | Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation |
| title_short | Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation |
| title_sort | artemisia extract suppresses nlrp3 and aim2 inflammasome activation by inhibition of asc phosphorylation |
| url | http://dx.doi.org/10.1155/2018/6054069 |
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