Exploring Therapeutic Potential of Luteolin in Periodontal Therapy: A Scoping Review
Periodontal disease is a destructive inflammatory process of the tooth-supporting tissues, that frequently results in tooth loss. Traditional periodontal therapies that use conventional instrumentation, often struggle to eliminate the disease effectively in inaccessible tooth parts. In addition, cu...
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Tehran University of Medical Sciences
2025-06-01
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| Series: | Traditional and Integrative Medicine |
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| Online Access: | https://jtim.tums.ac.ir/index.php/jtim/article/view/1674 |
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| author | Premalatha Bidadi Rajashekaraiah Suman Basavaraju Subbarao V. Madhunapantula Sumana Kumar Hemanth Kumar Somareddy Veena Haranahalli Raghavan |
| author_facet | Premalatha Bidadi Rajashekaraiah Suman Basavaraju Subbarao V. Madhunapantula Sumana Kumar Hemanth Kumar Somareddy Veena Haranahalli Raghavan |
| author_sort | Premalatha Bidadi Rajashekaraiah |
| collection | DOAJ |
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Periodontal disease is a destructive inflammatory process of the tooth-supporting tissues, that frequently results in tooth loss. Traditional periodontal therapies that use conventional instrumentation, often struggle to eliminate the disease effectively in inaccessible tooth parts. In addition, currently employed adjuvant agents in periodontal therapy have many undesirable side effects. This has encouraged the exploration of natural compounds with higher biocompatibility, therapeutic index, safety and lower cost. Luteolin, a flavonoid found in many herbs, vegetables, and fruits, exhibits several beneficial properties for periodontal health, suggesting that it could be an effective therapeutic agent in countering periodontal diseases. However, further exploration of its therapeutic potential is necessary. Thus, this study aimed to review the current evidence on luteolin’s therapeutic role in periodontal therapy. A comprehensive search in the scientific literature databases (PubMed, Scopus, and Web of Science) was conducted for studies investigating luteolin’s role in periodontal therapy. The search yielded 106 papers and after discarding 86 papers that did not fit the inclusion criteria, 20 studies were considered for analysis. These included 11 studies on cell lines, 4 related to animal experiments, 3 on microbiological profiling and 2 on human participants. Data regarding the study characteristics were extracted and summarized. All the evidence gathered from the reviewed papers consistently demonstrated that luteolin has potent biological activities such as anti-inflammatory, antioxidant and antimicrobial properties that combat the etiopathogenic factors affecting the establishment and progression of periodontal diseases. In conclusion, luteolin holds considerable promise as an adjuvant therapeutic agent in periodontal disease management. With further research, it could become a key component in periodontal treatment strategies.
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| format | Article |
| id | doaj-art-ccbbd63653fb472aa67735ecec4fa621 |
| institution | OA Journals |
| issn | 2476-5104 2476-5112 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Traditional and Integrative Medicine |
| spelling | doaj-art-ccbbd63653fb472aa67735ecec4fa6212025-08-20T02:36:31ZengTehran University of Medical SciencesTraditional and Integrative Medicine2476-51042476-51122025-06-0110210.18502/tim.v10i2.19064Exploring Therapeutic Potential of Luteolin in Periodontal Therapy: A Scoping ReviewPremalatha Bidadi Rajashekaraiah0Suman Basavaraju1Subbarao V. Madhunapantula2Sumana Kumar3Hemanth Kumar Somareddy4Veena Haranahalli Raghavan5Department of Oral Pathology and Microbiology, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru- 570015, IndiaDepartment of Periodontology, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru- 570015, IndiaDepartment of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education and Research, Mysuru- 570015, IndiaDepartment of Microbiology, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru 570015, IndiaDepartment of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru- 570015, IndiaDepartment of Periodontics, K.L.E.S Institute of Dental Sciences, Bengaluru, India Periodontal disease is a destructive inflammatory process of the tooth-supporting tissues, that frequently results in tooth loss. Traditional periodontal therapies that use conventional instrumentation, often struggle to eliminate the disease effectively in inaccessible tooth parts. In addition, currently employed adjuvant agents in periodontal therapy have many undesirable side effects. This has encouraged the exploration of natural compounds with higher biocompatibility, therapeutic index, safety and lower cost. Luteolin, a flavonoid found in many herbs, vegetables, and fruits, exhibits several beneficial properties for periodontal health, suggesting that it could be an effective therapeutic agent in countering periodontal diseases. However, further exploration of its therapeutic potential is necessary. Thus, this study aimed to review the current evidence on luteolin’s therapeutic role in periodontal therapy. A comprehensive search in the scientific literature databases (PubMed, Scopus, and Web of Science) was conducted for studies investigating luteolin’s role in periodontal therapy. The search yielded 106 papers and after discarding 86 papers that did not fit the inclusion criteria, 20 studies were considered for analysis. These included 11 studies on cell lines, 4 related to animal experiments, 3 on microbiological profiling and 2 on human participants. Data regarding the study characteristics were extracted and summarized. All the evidence gathered from the reviewed papers consistently demonstrated that luteolin has potent biological activities such as anti-inflammatory, antioxidant and antimicrobial properties that combat the etiopathogenic factors affecting the establishment and progression of periodontal diseases. In conclusion, luteolin holds considerable promise as an adjuvant therapeutic agent in periodontal disease management. With further research, it could become a key component in periodontal treatment strategies. https://jtim.tums.ac.ir/index.php/jtim/article/view/1674Anti-inflammatory agentsAntioxidantsLuteolinPeriodontal diseases |
| spellingShingle | Premalatha Bidadi Rajashekaraiah Suman Basavaraju Subbarao V. Madhunapantula Sumana Kumar Hemanth Kumar Somareddy Veena Haranahalli Raghavan Exploring Therapeutic Potential of Luteolin in Periodontal Therapy: A Scoping Review Traditional and Integrative Medicine Anti-inflammatory agents Antioxidants Luteolin Periodontal diseases |
| title | Exploring Therapeutic Potential of Luteolin in Periodontal Therapy: A Scoping Review |
| title_full | Exploring Therapeutic Potential of Luteolin in Periodontal Therapy: A Scoping Review |
| title_fullStr | Exploring Therapeutic Potential of Luteolin in Periodontal Therapy: A Scoping Review |
| title_full_unstemmed | Exploring Therapeutic Potential of Luteolin in Periodontal Therapy: A Scoping Review |
| title_short | Exploring Therapeutic Potential of Luteolin in Periodontal Therapy: A Scoping Review |
| title_sort | exploring therapeutic potential of luteolin in periodontal therapy a scoping review |
| topic | Anti-inflammatory agents Antioxidants Luteolin Periodontal diseases |
| url | https://jtim.tums.ac.ir/index.php/jtim/article/view/1674 |
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