Changes in Thyroid Antibodies after Microwave Ablation of Thyroid Nodules
Purpose. Microwave ablation (MWA) is a minimally invasive method for the thermal ablation of benign thyroid nodules and papillary thyroid cancer (PTC) and has shown promising results. The aim of this study was to investigate the impact of MWA on thyroid antibodies and associated influencing factors....
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/7916327 |
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| author | Zhen-Long Zhao Ying Wei Cai-Hong Liu Li-Li Peng Yan Li Nai-Cong Lu Jie Wu Ming-An Yu |
| author_facet | Zhen-Long Zhao Ying Wei Cai-Hong Liu Li-Li Peng Yan Li Nai-Cong Lu Jie Wu Ming-An Yu |
| author_sort | Zhen-Long Zhao |
| collection | DOAJ |
| description | Purpose. Microwave ablation (MWA) is a minimally invasive method for the thermal ablation of benign thyroid nodules and papillary thyroid cancer (PTC) and has shown promising results. The aim of this study was to investigate the impact of MWA on thyroid antibodies and associated influencing factors. Materials and Methods. A total of 119 patients, including 69 with benign thyroid nodules and 50 with PTC, underwent MWA between June 2019 and June 2021. The serum levels of (free) triiodothyronine, (free) thyroxine, thyrotropin, and antibodies against Tg (TGAb), thyrotropin receptors (TRAb), and thyroid peroxidase (TPOAb) were measured during the follow up. Results. One month after ablation, three patients (4.3%) in the benign group had hypothyroidism, and one (1.4%) had hyperthyroidism. Four patients (5.8%) had subclinical hypothyroidism, and two (2.9%) had subclinical hyperthyroidism. Among the PTC patients, two (4%) had hypothyroidism, and one (2%) had hyperthyroidism. Two patients (4%) had subclinical hypothyroidism, and one (2%) had subclinical hyperthyroidism. In the benign group, among patients with normal preablation antibodies, the postablation TGAb abnormal rate was 12.7%, the TPOAb level was 4.8%, and the TRAb level was 0%. Among PTC patients, the postablation TGAb abnormal rate was 11.4%, the TPOAb level was 8.7%, and the TRAb level was 4.0%. The cutoff value of preablation TGAb for predicting postoperative antibody abnormalities was 19.0 IU/mL, while that of TPOAb was 11.4 IU/mL. Conclusions. MWA of thyroid nodules had little influence on thyroid function and antibodies. Elevations in TGAb, TPOAb, and TRAb beyond the normal ranges after MWA may be related to high preablation levels of TGAb and TPOAb. |
| format | Article |
| id | doaj-art-ccb918cd31db402c9e734e1041385b5f |
| institution | DOAJ |
| issn | 1687-8345 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ccb918cd31db402c9e734e1041385b5f2025-08-20T03:19:31ZengWileyInternational Journal of Endocrinology1687-83452022-01-01202210.1155/2022/7916327Changes in Thyroid Antibodies after Microwave Ablation of Thyroid NodulesZhen-Long Zhao0Ying Wei1Cai-Hong Liu2Li-Li Peng3Yan Li4Nai-Cong Lu5Jie Wu6Ming-An Yu7Department of Interventional MedicineDepartment of Interventional MedicineDepartment of UltrasoundDepartment of Interventional MedicineDepartment of Interventional MedicineDepartment of Interventional MedicineDepartment of Interventional MedicineDepartment of Interventional MedicinePurpose. Microwave ablation (MWA) is a minimally invasive method for the thermal ablation of benign thyroid nodules and papillary thyroid cancer (PTC) and has shown promising results. The aim of this study was to investigate the impact of MWA on thyroid antibodies and associated influencing factors. Materials and Methods. A total of 119 patients, including 69 with benign thyroid nodules and 50 with PTC, underwent MWA between June 2019 and June 2021. The serum levels of (free) triiodothyronine, (free) thyroxine, thyrotropin, and antibodies against Tg (TGAb), thyrotropin receptors (TRAb), and thyroid peroxidase (TPOAb) were measured during the follow up. Results. One month after ablation, three patients (4.3%) in the benign group had hypothyroidism, and one (1.4%) had hyperthyroidism. Four patients (5.8%) had subclinical hypothyroidism, and two (2.9%) had subclinical hyperthyroidism. Among the PTC patients, two (4%) had hypothyroidism, and one (2%) had hyperthyroidism. Two patients (4%) had subclinical hypothyroidism, and one (2%) had subclinical hyperthyroidism. In the benign group, among patients with normal preablation antibodies, the postablation TGAb abnormal rate was 12.7%, the TPOAb level was 4.8%, and the TRAb level was 0%. Among PTC patients, the postablation TGAb abnormal rate was 11.4%, the TPOAb level was 8.7%, and the TRAb level was 4.0%. The cutoff value of preablation TGAb for predicting postoperative antibody abnormalities was 19.0 IU/mL, while that of TPOAb was 11.4 IU/mL. Conclusions. MWA of thyroid nodules had little influence on thyroid function and antibodies. Elevations in TGAb, TPOAb, and TRAb beyond the normal ranges after MWA may be related to high preablation levels of TGAb and TPOAb.http://dx.doi.org/10.1155/2022/7916327 |
| spellingShingle | Zhen-Long Zhao Ying Wei Cai-Hong Liu Li-Li Peng Yan Li Nai-Cong Lu Jie Wu Ming-An Yu Changes in Thyroid Antibodies after Microwave Ablation of Thyroid Nodules International Journal of Endocrinology |
| title | Changes in Thyroid Antibodies after Microwave Ablation of Thyroid Nodules |
| title_full | Changes in Thyroid Antibodies after Microwave Ablation of Thyroid Nodules |
| title_fullStr | Changes in Thyroid Antibodies after Microwave Ablation of Thyroid Nodules |
| title_full_unstemmed | Changes in Thyroid Antibodies after Microwave Ablation of Thyroid Nodules |
| title_short | Changes in Thyroid Antibodies after Microwave Ablation of Thyroid Nodules |
| title_sort | changes in thyroid antibodies after microwave ablation of thyroid nodules |
| url | http://dx.doi.org/10.1155/2022/7916327 |
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