Impaired ketogenesis in Leydig Cells drives testicular aging

Impaired ketogenesis in Leydig Cells drives testicular aging

Abstract Testicular aging commonly leads to testosterone deficiency and impaired spermatogenesis, yet the underlying mechanisms remain elusive. Here, we show that Leydig cells are particularly vulnerable to aging processes in testis. Single-cell RNA sequencing identifies the expression of Hmgcs2, th...

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Main Authors: Congyuan Liu, Hao Peng, Jiajie Yu, Peng Luo, Chuanfeng Xiong, Hong Chen, Hang Fan, Yuanchen Ma, Wangsheng Ou, Suyuan Zhang, Cuifeng Yang, Lerong Zhao, Yuchen Zhang, Xiaolu Guo, Qiong Ke, Tao Wang, Chunhua Deng, Weiqiang Li, Andy Peng Xiang, Kai Xia
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59591-8
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