Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae.
Anopheles gambiae is the principal Afrotropical vector for human malaria, in which olfaction mediates a wide range of both adult and larval behaviors. Indeed, mosquitoes depend on the ability to respond to chemical cues for feeding, host preference, and mate location/selection. Building upon previou...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-08-01
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| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000467&type=printable |
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| author | Chao Liu R Jason Pitts Jonathan D Bohbot Patrick L Jones Guirong Wang Laurence J Zwiebel |
| author_facet | Chao Liu R Jason Pitts Jonathan D Bohbot Patrick L Jones Guirong Wang Laurence J Zwiebel |
| author_sort | Chao Liu |
| collection | DOAJ |
| description | Anopheles gambiae is the principal Afrotropical vector for human malaria, in which olfaction mediates a wide range of both adult and larval behaviors. Indeed, mosquitoes depend on the ability to respond to chemical cues for feeding, host preference, and mate location/selection. Building upon previous work that has characterized a large family of An. gambiae odorant receptors (AgORs), we now use behavioral analyses and gene silencing to examine directly the role of AgORs, as well as a newly identified family of candidate chemosensory genes, the An. gambiae variant ionotropic receptors (AgIRs), in the larval olfactory system. Our results validate previous studies that directly implicate specific AgORs in behavioral responses to DEET as well as other odorants and reveal the existence of at least two distinct olfactory signaling pathways that are active in An. gambiae. One system depends directly on AgORs; the other is AgOR-independent and requires the expression and activity of AgIRs. In addition to clarifying the mechanistic basis for olfaction in this system, these advances may ultimately enhance the development of vector control strategies, targeting olfactory pathways in mosquitoes to reduce the catastrophic effects of malaria and other mosquito-borne diseases. |
| format | Article |
| id | doaj-art-ccb4bcb569df43ff8afb72cd473142bf |
| institution | OA Journals |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2010-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-ccb4bcb569df43ff8afb72cd473142bf2025-08-20T02:31:48ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852010-08-0188e100046710.1371/journal.pbio.1000467Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae.Chao LiuR Jason PittsJonathan D BohbotPatrick L JonesGuirong WangLaurence J ZwiebelAnopheles gambiae is the principal Afrotropical vector for human malaria, in which olfaction mediates a wide range of both adult and larval behaviors. Indeed, mosquitoes depend on the ability to respond to chemical cues for feeding, host preference, and mate location/selection. Building upon previous work that has characterized a large family of An. gambiae odorant receptors (AgORs), we now use behavioral analyses and gene silencing to examine directly the role of AgORs, as well as a newly identified family of candidate chemosensory genes, the An. gambiae variant ionotropic receptors (AgIRs), in the larval olfactory system. Our results validate previous studies that directly implicate specific AgORs in behavioral responses to DEET as well as other odorants and reveal the existence of at least two distinct olfactory signaling pathways that are active in An. gambiae. One system depends directly on AgORs; the other is AgOR-independent and requires the expression and activity of AgIRs. In addition to clarifying the mechanistic basis for olfaction in this system, these advances may ultimately enhance the development of vector control strategies, targeting olfactory pathways in mosquitoes to reduce the catastrophic effects of malaria and other mosquito-borne diseases.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000467&type=printable |
| spellingShingle | Chao Liu R Jason Pitts Jonathan D Bohbot Patrick L Jones Guirong Wang Laurence J Zwiebel Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae. PLoS Biology |
| title | Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae. |
| title_full | Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae. |
| title_fullStr | Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae. |
| title_full_unstemmed | Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae. |
| title_short | Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae. |
| title_sort | distinct olfactory signaling mechanisms in the malaria vector mosquito anopheles gambiae |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000467&type=printable |
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