Physiological Aldosterone Concentrations Are Associated with Alterations of Lipid Metabolism: Observations from the General Population
Objective. Aldosterone and high-density lipoprotein cholesterol (HDL-C) are involved in many pathophysiological processes that contribute to the development of cardiovascular diseases. Previously, associations between the concentrations of aldosterone and certain components of the lipid metabolism i...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/4128174 |
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| author | M. Hannich H. Wallaschofski M. Nauck M. Reincke C. Adolf H. Völzke R. Rettig A. Hannemann |
| author_facet | M. Hannich H. Wallaschofski M. Nauck M. Reincke C. Adolf H. Völzke R. Rettig A. Hannemann |
| author_sort | M. Hannich |
| collection | DOAJ |
| description | Objective. Aldosterone and high-density lipoprotein cholesterol (HDL-C) are involved in many pathophysiological processes that contribute to the development of cardiovascular diseases. Previously, associations between the concentrations of aldosterone and certain components of the lipid metabolism in the peripheral circulation were suggested, but data from the general population is sparse. We therefore aimed to assess the associations between aldosterone and HDL-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides, or non-HDL-C in the general adult population. Methods. Data from 793 men and 938 women aged 25–85 years who participated in the first follow-up of the Study of Health in Pomerania were obtained. The associations of aldosterone with serum lipid concentrations were assessed in multivariable linear regression models adjusted for sex, age, body mass index (BMI), estimated glomerular filtration rate (eGFR), and HbA1c. Results. The linear regression models showed statistically significant positive associations of aldosterone with LDL-C (β-coefficient = 0.022, standard error = 0.010, p=0.03) and non-HDL-C (β-coefficient = 0.023, standard error = 0.009, p=0.01) as well as an inverse association of aldosterone with HDL-C (β-coefficient = −0.022, standard error = 0.011, p=0.04). Conclusions. The present data show that plasma aldosterone is positively associated with LDL-C and non-HDL-C and inversely associated with HDL-C in the general population. Our data thus suggests that aldosterone concentrations within the physiological range may be related to alterations of lipid metabolism. |
| format | Article |
| id | doaj-art-ccaff7ef1ae0459890f132d6ed0a3216 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ccaff7ef1ae0459890f132d6ed0a32162025-02-03T00:59:50ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/41281744128174Physiological Aldosterone Concentrations Are Associated with Alterations of Lipid Metabolism: Observations from the General PopulationM. Hannich0H. Wallaschofski1M. Nauck2M. Reincke3C. Adolf4H. Völzke5R. Rettig6A. Hannemann7Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, GermanyInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, GermanyInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, GermanyMedical Department IV, Klinikum Innenstadt, Ludwig-Maximilian University of Munich, Munich, GermanyMedical Department IV, Klinikum Innenstadt, Ludwig-Maximilian University of Munich, Munich, GermanyGerman Centre for Cardiovascular Research, Partner site Greifswald, Greifswald, GermanyInstitute of Physiology, University Medicine Greifswald, Greifswald, GermanyInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, GermanyObjective. Aldosterone and high-density lipoprotein cholesterol (HDL-C) are involved in many pathophysiological processes that contribute to the development of cardiovascular diseases. Previously, associations between the concentrations of aldosterone and certain components of the lipid metabolism in the peripheral circulation were suggested, but data from the general population is sparse. We therefore aimed to assess the associations between aldosterone and HDL-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides, or non-HDL-C in the general adult population. Methods. Data from 793 men and 938 women aged 25–85 years who participated in the first follow-up of the Study of Health in Pomerania were obtained. The associations of aldosterone with serum lipid concentrations were assessed in multivariable linear regression models adjusted for sex, age, body mass index (BMI), estimated glomerular filtration rate (eGFR), and HbA1c. Results. The linear regression models showed statistically significant positive associations of aldosterone with LDL-C (β-coefficient = 0.022, standard error = 0.010, p=0.03) and non-HDL-C (β-coefficient = 0.023, standard error = 0.009, p=0.01) as well as an inverse association of aldosterone with HDL-C (β-coefficient = −0.022, standard error = 0.011, p=0.04). Conclusions. The present data show that plasma aldosterone is positively associated with LDL-C and non-HDL-C and inversely associated with HDL-C in the general population. Our data thus suggests that aldosterone concentrations within the physiological range may be related to alterations of lipid metabolism.http://dx.doi.org/10.1155/2018/4128174 |
| spellingShingle | M. Hannich H. Wallaschofski M. Nauck M. Reincke C. Adolf H. Völzke R. Rettig A. Hannemann Physiological Aldosterone Concentrations Are Associated with Alterations of Lipid Metabolism: Observations from the General Population International Journal of Endocrinology |
| title | Physiological Aldosterone Concentrations Are Associated with Alterations of Lipid Metabolism: Observations from the General Population |
| title_full | Physiological Aldosterone Concentrations Are Associated with Alterations of Lipid Metabolism: Observations from the General Population |
| title_fullStr | Physiological Aldosterone Concentrations Are Associated with Alterations of Lipid Metabolism: Observations from the General Population |
| title_full_unstemmed | Physiological Aldosterone Concentrations Are Associated with Alterations of Lipid Metabolism: Observations from the General Population |
| title_short | Physiological Aldosterone Concentrations Are Associated with Alterations of Lipid Metabolism: Observations from the General Population |
| title_sort | physiological aldosterone concentrations are associated with alterations of lipid metabolism observations from the general population |
| url | http://dx.doi.org/10.1155/2018/4128174 |
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