Epigallocatechin Gallate in <i>Camellia sinensis</i> Ameliorates Skin Aging by Reducing Mitochondrial ROS Production
<b>Background:</b> Reactive oxygen species (ROS) generated by mitochondrial dysfunction damage cellular organelles and contribute to skin aging. Therefore, strategies to reduce mitochondrial ROS production are considered important for alleviating skin aging, but no effective methods have...
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MDPI AG
2025-04-01
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| author | Ji Ho Park Eun Young Jeong Ye Hyang Kim So Yoon Cha Ha Yeon Kim Yeon Kyung Nam Jin Seong Park So Yeon Kim Yoo Jin Lee Jee Hee Yoon Byeonghyeon So Duyeol Kim Minseon Kim Youngjoo Byun Yun Haeng Lee Song Seok Shin Joon Tae Park |
| author_facet | Ji Ho Park Eun Young Jeong Ye Hyang Kim So Yoon Cha Ha Yeon Kim Yeon Kyung Nam Jin Seong Park So Yeon Kim Yoo Jin Lee Jee Hee Yoon Byeonghyeon So Duyeol Kim Minseon Kim Youngjoo Byun Yun Haeng Lee Song Seok Shin Joon Tae Park |
| author_sort | Ji Ho Park |
| collection | DOAJ |
| description | <b>Background:</b> Reactive oxygen species (ROS) generated by mitochondrial dysfunction damage cellular organelles and contribute to skin aging. Therefore, strategies to reduce mitochondrial ROS production are considered important for alleviating skin aging, but no effective methods have been identified. <b>Methods:</b> In this study, we evaluated substances utilized as cosmetic ingredients and discovered <i>Camellia sinensis</i> (<i>C. sinensis</i>) as a substance that reduces mitochondrial ROS levels. <b>Results:</b> <i>C. sinensis</i> extracts were found to act as senolytics that selectively kill senescent fibroblasts containing dysfunctional mitochondria. In addition, <i>C. sinensis</i> extracts facilitated efficient electron transport in the mitochondrial electron transport chain (ETC) by increasing the efficiency of oxidative phosphorylation (OXPHOS), thereby reducing mitochondrial ROS production, a byproduct of the inefficient ETC. This novel mechanism of <i>C. sinensis</i> extracts led to the restoration of skin aging and the skin barrier. Furthermore, epigallocatechin gallate (EGCG) was identified as an active ingredient that plays a key role in <i>C. sinensis</i> extract-mediated skin aging recovery. Indeed, similar to <i>C. sinensis</i> extracts, EGCG reduced ROS and improved skin aging in an artificial skin model. <b>Conclusions:</b> Our data uncovered a novel mechanism by which <i>C. sinensis</i> extract reverses skin aging by reducing mitochondrial ROS production via selective senescent cell death/increased OXPHOS efficiency. Our results suggest that <i>C. sinensis</i> extract or EGCG may be used as a therapeutic agent to reverse skin aging in clinical and cosmetic applications. |
| format | Article |
| id | doaj-art-ccaf7d3114b84d25a327de9e7066bdca |
| institution | OA Journals |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Pharmaceuticals |
| spelling | doaj-art-ccaf7d3114b84d25a327de9e7066bdca2025-08-20T01:56:35ZengMDPI AGPharmaceuticals1424-82472025-04-0118561210.3390/ph18050612Epigallocatechin Gallate in <i>Camellia sinensis</i> Ameliorates Skin Aging by Reducing Mitochondrial ROS ProductionJi Ho Park0Eun Young Jeong1Ye Hyang Kim2So Yoon Cha3Ha Yeon Kim4Yeon Kyung Nam5Jin Seong Park6So Yeon Kim7Yoo Jin Lee8Jee Hee Yoon9Byeonghyeon So10Duyeol Kim11Minseon Kim12Youngjoo Byun13Yun Haeng Lee14Song Seok Shin15Joon Tae Park16Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of KoreaHyundai Bioland Co., Ltd., 22, Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28162, Republic of KoreaHyundai Bioland Co., Ltd., 22, Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28162, Republic of KoreaHyundai Bioland Co., Ltd., 22, Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28162, Republic of KoreaHyundai Bioland Co., Ltd., 22, Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28162, Republic of KoreaHyundai Bioland Co., Ltd., 22, Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28162, Republic of KoreaHyundai Bioland Co., Ltd., 22, Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28162, Republic of KoreaHyundai Bioland Co., Ltd., 22, Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28162, Republic of KoreaDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of KoreaDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of KoreaDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of KoreaDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of KoreaDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of KoreaCollege of Pharmacy, Korea University, Sejong 30019, Republic of KoreaDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of KoreaHyundai Bioland Co., Ltd., 22, Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28162, Republic of KoreaDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea<b>Background:</b> Reactive oxygen species (ROS) generated by mitochondrial dysfunction damage cellular organelles and contribute to skin aging. Therefore, strategies to reduce mitochondrial ROS production are considered important for alleviating skin aging, but no effective methods have been identified. <b>Methods:</b> In this study, we evaluated substances utilized as cosmetic ingredients and discovered <i>Camellia sinensis</i> (<i>C. sinensis</i>) as a substance that reduces mitochondrial ROS levels. <b>Results:</b> <i>C. sinensis</i> extracts were found to act as senolytics that selectively kill senescent fibroblasts containing dysfunctional mitochondria. In addition, <i>C. sinensis</i> extracts facilitated efficient electron transport in the mitochondrial electron transport chain (ETC) by increasing the efficiency of oxidative phosphorylation (OXPHOS), thereby reducing mitochondrial ROS production, a byproduct of the inefficient ETC. This novel mechanism of <i>C. sinensis</i> extracts led to the restoration of skin aging and the skin barrier. Furthermore, epigallocatechin gallate (EGCG) was identified as an active ingredient that plays a key role in <i>C. sinensis</i> extract-mediated skin aging recovery. Indeed, similar to <i>C. sinensis</i> extracts, EGCG reduced ROS and improved skin aging in an artificial skin model. <b>Conclusions:</b> Our data uncovered a novel mechanism by which <i>C. sinensis</i> extract reverses skin aging by reducing mitochondrial ROS production via selective senescent cell death/increased OXPHOS efficiency. Our results suggest that <i>C. sinensis</i> extract or EGCG may be used as a therapeutic agent to reverse skin aging in clinical and cosmetic applications.https://www.mdpi.com/1424-8247/18/5/612<i>Camellia sinensis</i>reactive oxygen species (ROS)senescence rejuvenationskin aging recovery |
| spellingShingle | Ji Ho Park Eun Young Jeong Ye Hyang Kim So Yoon Cha Ha Yeon Kim Yeon Kyung Nam Jin Seong Park So Yeon Kim Yoo Jin Lee Jee Hee Yoon Byeonghyeon So Duyeol Kim Minseon Kim Youngjoo Byun Yun Haeng Lee Song Seok Shin Joon Tae Park Epigallocatechin Gallate in <i>Camellia sinensis</i> Ameliorates Skin Aging by Reducing Mitochondrial ROS Production Pharmaceuticals <i>Camellia sinensis</i> reactive oxygen species (ROS) senescence rejuvenation skin aging recovery |
| title | Epigallocatechin Gallate in <i>Camellia sinensis</i> Ameliorates Skin Aging by Reducing Mitochondrial ROS Production |
| title_full | Epigallocatechin Gallate in <i>Camellia sinensis</i> Ameliorates Skin Aging by Reducing Mitochondrial ROS Production |
| title_fullStr | Epigallocatechin Gallate in <i>Camellia sinensis</i> Ameliorates Skin Aging by Reducing Mitochondrial ROS Production |
| title_full_unstemmed | Epigallocatechin Gallate in <i>Camellia sinensis</i> Ameliorates Skin Aging by Reducing Mitochondrial ROS Production |
| title_short | Epigallocatechin Gallate in <i>Camellia sinensis</i> Ameliorates Skin Aging by Reducing Mitochondrial ROS Production |
| title_sort | epigallocatechin gallate in i camellia sinensis i ameliorates skin aging by reducing mitochondrial ros production |
| topic | <i>Camellia sinensis</i> reactive oxygen species (ROS) senescence rejuvenation skin aging recovery |
| url | https://www.mdpi.com/1424-8247/18/5/612 |
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