Development, Stability, and In Vitro/In Vivo Studies of Volatile Oil Pickering Emulsion Stabilized by Modified Amber
Volatile oil stabilization strategies based on encapsulation with a large number of excipients limit further applications. The primary objective of this study is to improve the stability of volatile oils using Pickering emulsion (PE) stabilized by Chinese medicinal powder based on the principle of “...
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MDPI AG
2024-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/17/9/1117 |
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| author | Maomao Zhu Zhonghuan Qu Yanjun Yang Ruyu Shi Bing Yang Yajun Shi Junbo Zou Xiaobin Jia |
| author_facet | Maomao Zhu Zhonghuan Qu Yanjun Yang Ruyu Shi Bing Yang Yajun Shi Junbo Zou Xiaobin Jia |
| author_sort | Maomao Zhu |
| collection | DOAJ |
| description | Volatile oil stabilization strategies based on encapsulation with a large number of excipients limit further applications. The primary objective of this study is to improve the stability of volatile oils using Pickering emulsion (PE) stabilized by Chinese medicinal powder based on the principle of “integrating drug and excipient”. Modified amber was acquired through surface modification, and a stable oil-in-water PE loaded with <i>Acorus tatarinowii</i> volatile oil (ATVO) was constructed from modified amber. The stability, including the peroxide value (PV), malondialdehyde (MDA) content, and the content and composition of volatile components in modified amber-PE (MAPE) under intense light exposure, was analyzed deeply. In addition, the in vitro release and pharmacokinetics of MAPE and ATVO were investigated. The results demonstrate that the PV and MDA content in MAPE were significantly lower than in free ATVO, and the content and composition of volatile components in MAPE were closer to those in untreated ATVO. The release kinetics of <i>β</i>-asarone and <i>α</i>-asarone in MAPE demonstrated rapid and higher release, and pharmacokinetic studies show that MAPE has better bioavailability. This research provides a distinctive Chinese medicine solution to address the vaporization of volatile oil in solid formulations. |
| format | Article |
| id | doaj-art-ccaa2e4d5ea74d2ca933626ea33113a9 |
| institution | OA Journals |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-ccaa2e4d5ea74d2ca933626ea33113a92025-08-20T01:55:45ZengMDPI AGPharmaceuticals1424-82472024-08-01179111710.3390/ph17091117Development, Stability, and In Vitro/In Vivo Studies of Volatile Oil Pickering Emulsion Stabilized by Modified AmberMaomao Zhu0Zhonghuan Qu1Yanjun Yang2Ruyu Shi3Bing Yang4Yajun Shi5Junbo Zou6Xiaobin Jia7Innovation Center for Industry-Education Integration of Pediatrics and Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaShaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, ChinaInnovation Center for Industry-Education Integration of Pediatrics and Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaInnovation Center for Industry-Education Integration of Pediatrics and Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaInnovation Center for Industry-Education Integration of Pediatrics and Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaShaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, ChinaShaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, ChinaInnovation Center for Industry-Education Integration of Pediatrics and Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaVolatile oil stabilization strategies based on encapsulation with a large number of excipients limit further applications. The primary objective of this study is to improve the stability of volatile oils using Pickering emulsion (PE) stabilized by Chinese medicinal powder based on the principle of “integrating drug and excipient”. Modified amber was acquired through surface modification, and a stable oil-in-water PE loaded with <i>Acorus tatarinowii</i> volatile oil (ATVO) was constructed from modified amber. The stability, including the peroxide value (PV), malondialdehyde (MDA) content, and the content and composition of volatile components in modified amber-PE (MAPE) under intense light exposure, was analyzed deeply. In addition, the in vitro release and pharmacokinetics of MAPE and ATVO were investigated. The results demonstrate that the PV and MDA content in MAPE were significantly lower than in free ATVO, and the content and composition of volatile components in MAPE were closer to those in untreated ATVO. The release kinetics of <i>β</i>-asarone and <i>α</i>-asarone in MAPE demonstrated rapid and higher release, and pharmacokinetic studies show that MAPE has better bioavailability. This research provides a distinctive Chinese medicine solution to address the vaporization of volatile oil in solid formulations.https://www.mdpi.com/1424-8247/17/9/1117<i>Acorus tatarinowii</i> volatile oilstabilityPickering emulsionmodified medicinal particlespharmacokinetics |
| spellingShingle | Maomao Zhu Zhonghuan Qu Yanjun Yang Ruyu Shi Bing Yang Yajun Shi Junbo Zou Xiaobin Jia Development, Stability, and In Vitro/In Vivo Studies of Volatile Oil Pickering Emulsion Stabilized by Modified Amber Pharmaceuticals <i>Acorus tatarinowii</i> volatile oil stability Pickering emulsion modified medicinal particles pharmacokinetics |
| title | Development, Stability, and In Vitro/In Vivo Studies of Volatile Oil Pickering Emulsion Stabilized by Modified Amber |
| title_full | Development, Stability, and In Vitro/In Vivo Studies of Volatile Oil Pickering Emulsion Stabilized by Modified Amber |
| title_fullStr | Development, Stability, and In Vitro/In Vivo Studies of Volatile Oil Pickering Emulsion Stabilized by Modified Amber |
| title_full_unstemmed | Development, Stability, and In Vitro/In Vivo Studies of Volatile Oil Pickering Emulsion Stabilized by Modified Amber |
| title_short | Development, Stability, and In Vitro/In Vivo Studies of Volatile Oil Pickering Emulsion Stabilized by Modified Amber |
| title_sort | development stability and in vitro in vivo studies of volatile oil pickering emulsion stabilized by modified amber |
| topic | <i>Acorus tatarinowii</i> volatile oil stability Pickering emulsion modified medicinal particles pharmacokinetics |
| url | https://www.mdpi.com/1424-8247/17/9/1117 |
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