Feasibility of a novel self‐assembling submucosal injection peptide solution for endoscopic mucosal resection of colorectal lesions: A multicenter study
Abstract Objectives Although a novel submucosal injection material consisting of a fully synthetic, self‐assembling peptide solution, PuraLift, has recently become commercially available in Japan, there are a few reports regarding the usefulness of this solution. The aim of this study was to investi...
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2025-04-01
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| Online Access: | https://doi.org/10.1002/deo2.70069 |
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| author | Keigo Sato Takehide Fukuchi Shinpei Kondo Yuya Nakano Yoko Hachisu Kengo Kasuga Ayako Matsui Hironori Aoki Kohei Takizawa Shiko Kuribayashi Yoji Takeuchi Toshio Uraoka |
| author_facet | Keigo Sato Takehide Fukuchi Shinpei Kondo Yuya Nakano Yoko Hachisu Kengo Kasuga Ayako Matsui Hironori Aoki Kohei Takizawa Shiko Kuribayashi Yoji Takeuchi Toshio Uraoka |
| author_sort | Keigo Sato |
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| description | Abstract Objectives Although a novel submucosal injection material consisting of a fully synthetic, self‐assembling peptide solution, PuraLift, has recently become commercially available in Japan, there are a few reports regarding the usefulness of this solution. The aim of this study was to investigate the feasibility of PuraLift for conventional endoscopic mucosal resection (EMR) in clinical practice. Methods This multicenter retrospective study was conducted at the endoscopy units of five institutions from January 2023 to May 2023. Consecutive patients who underwent EMR with PuraLift for 5–20‐mm colorectal lesions were included in the introduction of this solution at each institute. The primary endpoint was the “effective resection” rate, defined as pathological complete resection, with “effective injection” defined as requiring no more than one additional injection due to adequate maintenance of mucosal lifting during EMR. Results In total, 110 lesions in 70 patients were treated by conventional EMR using PuraLift. En‐bloc resection was performed for 109 (99%) lesions, and complete resection was performed for 102 (93%) lesions. More than 95% of the lesions were neoplastic. Additional injections were required in only two lesions. Both were single additional injections, and the median overall injection volume was 1.5 mL. Therefore, the effective injection rate was 93% (95% confidence interval, 86%–96%). No adverse events occurred during the study period. Conclusions Although direct comparison with other materials is required, PuraLift seems feasible as an injection material for EMR. |
| format | Article |
| id | doaj-art-cca4c09fbc5e49babb3272a50ff16e46 |
| institution | DOAJ |
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| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-cca4c09fbc5e49babb3272a50ff16e462025-08-20T03:13:51ZengWileyDEN Open2692-46092025-04-0151n/an/a10.1002/deo2.70069Feasibility of a novel self‐assembling submucosal injection peptide solution for endoscopic mucosal resection of colorectal lesions: A multicenter studyKeigo Sato0Takehide Fukuchi1Shinpei Kondo2Yuya Nakano3Yoko Hachisu4Kengo Kasuga5Ayako Matsui6Hironori Aoki7Kohei Takizawa8Shiko Kuribayashi9Yoji Takeuchi10Toshio Uraoka11Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Gunma JapanDepartment of Gastroenterology Fujisawa City Hospital Kanagawa JapanDepartment of Gastroenterology Fujisawa City Hospital Kanagawa JapanDepartment of Gastroenterology Gunma Saiseikai Maebashi Hospital Gunma JapanDepartment of Gastroenterology Gunma Saiseikai Maebashi Hospital Gunma JapanDepartment of Gastroenterology Isesaki Municipal Hospital Gunma JapanDepartment of Gastroenterology Isesaki Municipal Hospital Gunma JapanEndoscopy Center Koyukai Shin‐Sapporo Hospital Hokkaido JapanEndoscopy Center Koyukai Shin‐Sapporo Hospital Hokkaido JapanDepartment of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Gunma JapanDepartment of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Gunma JapanDepartment of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Gunma JapanAbstract Objectives Although a novel submucosal injection material consisting of a fully synthetic, self‐assembling peptide solution, PuraLift, has recently become commercially available in Japan, there are a few reports regarding the usefulness of this solution. The aim of this study was to investigate the feasibility of PuraLift for conventional endoscopic mucosal resection (EMR) in clinical practice. Methods This multicenter retrospective study was conducted at the endoscopy units of five institutions from January 2023 to May 2023. Consecutive patients who underwent EMR with PuraLift for 5–20‐mm colorectal lesions were included in the introduction of this solution at each institute. The primary endpoint was the “effective resection” rate, defined as pathological complete resection, with “effective injection” defined as requiring no more than one additional injection due to adequate maintenance of mucosal lifting during EMR. Results In total, 110 lesions in 70 patients were treated by conventional EMR using PuraLift. En‐bloc resection was performed for 109 (99%) lesions, and complete resection was performed for 102 (93%) lesions. More than 95% of the lesions were neoplastic. Additional injections were required in only two lesions. Both were single additional injections, and the median overall injection volume was 1.5 mL. Therefore, the effective injection rate was 93% (95% confidence interval, 86%–96%). No adverse events occurred during the study period. Conclusions Although direct comparison with other materials is required, PuraLift seems feasible as an injection material for EMR.https://doi.org/10.1002/deo2.70069coloncolonoscopycolorectal polypsendoscopic mucosal resectionendoscopic resection |
| spellingShingle | Keigo Sato Takehide Fukuchi Shinpei Kondo Yuya Nakano Yoko Hachisu Kengo Kasuga Ayako Matsui Hironori Aoki Kohei Takizawa Shiko Kuribayashi Yoji Takeuchi Toshio Uraoka Feasibility of a novel self‐assembling submucosal injection peptide solution for endoscopic mucosal resection of colorectal lesions: A multicenter study DEN Open colon colonoscopy colorectal polyps endoscopic mucosal resection endoscopic resection |
| title | Feasibility of a novel self‐assembling submucosal injection peptide solution for endoscopic mucosal resection of colorectal lesions: A multicenter study |
| title_full | Feasibility of a novel self‐assembling submucosal injection peptide solution for endoscopic mucosal resection of colorectal lesions: A multicenter study |
| title_fullStr | Feasibility of a novel self‐assembling submucosal injection peptide solution for endoscopic mucosal resection of colorectal lesions: A multicenter study |
| title_full_unstemmed | Feasibility of a novel self‐assembling submucosal injection peptide solution for endoscopic mucosal resection of colorectal lesions: A multicenter study |
| title_short | Feasibility of a novel self‐assembling submucosal injection peptide solution for endoscopic mucosal resection of colorectal lesions: A multicenter study |
| title_sort | feasibility of a novel self assembling submucosal injection peptide solution for endoscopic mucosal resection of colorectal lesions a multicenter study |
| topic | colon colonoscopy colorectal polyps endoscopic mucosal resection endoscopic resection |
| url | https://doi.org/10.1002/deo2.70069 |
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