Potent bivalent nanobody constructs that protect against the SARS-CoV-2 XBB variant

Abstract Most antibody-based therapeutics approved for SARS-CoV-2 treatment have shown greatly reduced neutralization activity against emerging Omicron variants. To target recent Omicron variants, we developed XBB-specific antibody-like therapeutics by screening a yeast surface-displayed single-doma...

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Bibliographic Details
Main Authors: Peter J. Halfmann, Jeong Soo Lee, Nikki McArthur, Ojas Gupta, Yoshihiro Kawaoka, Ravi S. Kane
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Viruses
Online Access:https://doi.org/10.1038/s44298-025-00101-4
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