TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction.

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction.

Interferons play a critical role in regulating host immune responses to SARS-CoV-2, but the interferon (IFN)-stimulated gene (ISG) effectors that inhibit SARS-CoV-2 are not well characterized. The IFN-inducible short isoform of human nuclear receptor coactivator 7 (NCOA7) inhibits endocytic virus en...

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Main Authors: Hataf Khan, Helena Winstone, Jose M Jimenez-Guardeño, Carl Graham, Katie J Doores, Caroline Goujon, David A Matthews, Andrew D Davidson, Suzannah J Rihn, Massimo Palmarini, Stuart J D Neil, Michael H Malim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-11-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009820&type=printable
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