Naringin in cholestatic liver ischemia-reperfusion injury
ABSTRACT Purpose: To evaluate the potential protective effects of naringin on liver by oxidative parameters and signal peptide-CUB-EGF-like domain-containing protein (SCUBE)-1 and 2 in an experimental cholestatic liver ischemia reperfusion (IR) model. Methods: Twenty-four female rats were divided...
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2025-06-01
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| Series: | Acta Cirúrgica Brasileira |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100225&lng=en&tlng=en |
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| author | Arif Aslaner Kemal Eyvaz Erhan Aydemir Şenay Yıldırım Kübra Kılıç Kartal Hamit Yaşar Ellidağ Uğur Doğan |
| author_facet | Arif Aslaner Kemal Eyvaz Erhan Aydemir Şenay Yıldırım Kübra Kılıç Kartal Hamit Yaşar Ellidağ Uğur Doğan |
| author_sort | Arif Aslaner |
| collection | DOAJ |
| description | ABSTRACT Purpose: To evaluate the potential protective effects of naringin on liver by oxidative parameters and signal peptide-CUB-EGF-like domain-containing protein (SCUBE)-1 and 2 in an experimental cholestatic liver ischemia reperfusion (IR) model. Methods: Twenty-four female rats were divided into three groups; sham, control, and treatment. Groups 2 and 3 underwent bile duct ligation, and one week later, 45 min of ischemia and 1 hour of relaparotomy and reperfusion were performed. To the treatment group, naringin was administered through relaparotomy. Liver tissue and blood samples were taken. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), direct bilirubin (DBIL), ischemia-modified albumin (IMA), SCUBE-1, SCUBE-2, total antioxidant status (TAS), and total oxidant status (TOS) levels were also examined. Results: Serum ALT, AST, ALP, TBIL, DBIL, and IMA levels were higher in groups 2 and 3. There was no significant difference in terms of SCUBE-1 and 2 levels (p > 0.05). TAS was the highest in group 3, and TOS was the highest in group 2 and lower in group 3. In histopathological analysis, all parameters were statistically significant between group 3 and the other groups (p < 0.05). Conclusion: Naringin has promising results in the treatment of experimental IR injury in cholestatic liver due to its antioxidant effects. We think that it can be used in clinical studies after more comprehensive studies investigating its effects on IR damage in cholestatic liver. |
| format | Article |
| id | doaj-art-cc8edef2e77d475c8a86f2af6980c3c9 |
| institution | OA Journals |
| issn | 1678-2674 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj-art-cc8edef2e77d475c8a86f2af6980c3c92025-08-20T02:35:35ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira1678-26742025-06-014010.1590/acb404225Naringin in cholestatic liver ischemia-reperfusion injuryArif Aslanerhttps://orcid.org/0000-0001-7346-6977Kemal Eyvazhttps://orcid.org/0000-0002-7410-107XErhan Aydemirhttps://orcid.org/0000-0002-9586-819XŞenay Yıldırımhttps://orcid.org/0000-0002-1457-7957Kübra Kılıç Kartalhttps://orcid.org/0009-0006-4490-2630Hamit Yaşar Ellidağhttps://orcid.org/0000-0002-7511-2547Uğur Doğanhttps://orcid.org/0000-0001-8097-3168ABSTRACT Purpose: To evaluate the potential protective effects of naringin on liver by oxidative parameters and signal peptide-CUB-EGF-like domain-containing protein (SCUBE)-1 and 2 in an experimental cholestatic liver ischemia reperfusion (IR) model. Methods: Twenty-four female rats were divided into three groups; sham, control, and treatment. Groups 2 and 3 underwent bile duct ligation, and one week later, 45 min of ischemia and 1 hour of relaparotomy and reperfusion were performed. To the treatment group, naringin was administered through relaparotomy. Liver tissue and blood samples were taken. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), direct bilirubin (DBIL), ischemia-modified albumin (IMA), SCUBE-1, SCUBE-2, total antioxidant status (TAS), and total oxidant status (TOS) levels were also examined. Results: Serum ALT, AST, ALP, TBIL, DBIL, and IMA levels were higher in groups 2 and 3. There was no significant difference in terms of SCUBE-1 and 2 levels (p > 0.05). TAS was the highest in group 3, and TOS was the highest in group 2 and lower in group 3. In histopathological analysis, all parameters were statistically significant between group 3 and the other groups (p < 0.05). Conclusion: Naringin has promising results in the treatment of experimental IR injury in cholestatic liver due to its antioxidant effects. We think that it can be used in clinical studies after more comprehensive studies investigating its effects on IR damage in cholestatic liver.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100225&lng=en&tlng=enLiverCholestasisIschemiaPerfusion |
| spellingShingle | Arif Aslaner Kemal Eyvaz Erhan Aydemir Şenay Yıldırım Kübra Kılıç Kartal Hamit Yaşar Ellidağ Uğur Doğan Naringin in cholestatic liver ischemia-reperfusion injury Acta Cirúrgica Brasileira Liver Cholestasis Ischemia Perfusion |
| title | Naringin in cholestatic liver ischemia-reperfusion injury |
| title_full | Naringin in cholestatic liver ischemia-reperfusion injury |
| title_fullStr | Naringin in cholestatic liver ischemia-reperfusion injury |
| title_full_unstemmed | Naringin in cholestatic liver ischemia-reperfusion injury |
| title_short | Naringin in cholestatic liver ischemia-reperfusion injury |
| title_sort | naringin in cholestatic liver ischemia reperfusion injury |
| topic | Liver Cholestasis Ischemia Perfusion |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100225&lng=en&tlng=en |
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