Meta-epigenetic shifts in T cell aging and aging-related dysfunction

Abstract Epigenetic regulation, including DNA methylation and histone modifications, play a pivotal role in shaping T cell functionality throughout life. With aging, these epigenetic changes profoundly affect gene expression, altering T cell plasticity, activation, and differentiation. These modific...

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Bibliographic Details
Main Authors: Lorène Rousseau, Karina L. Hajdu, Ping-Chih Ho
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Biomedical Science
Subjects:
Online Access:https://doi.org/10.1186/s12929-025-01146-6
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