Phototherapy in vitiligo
Vitiligo is a chronic dermatological condition characterized by the progressive loss of melanocytes, leading to depigmented patches on the skin. Phototherapy has emerged as a cornerstone in the management of vitiligo, offering a promising approach to disease stabilization and repigmentation. This re...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Pigment International |
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| Online Access: | https://journals.lww.com/10.4103/pigmentinternational_52_24 |
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| author | Anuradha Bishnoi Iltefat Hamzavi |
| author_facet | Anuradha Bishnoi Iltefat Hamzavi |
| author_sort | Anuradha Bishnoi |
| collection | DOAJ |
| description | Vitiligo is a chronic dermatological condition characterized by the progressive loss of melanocytes, leading to depigmented patches on the skin. Phototherapy has emerged as a cornerstone in the management of vitiligo, offering a promising approach to disease stabilization and repigmentation. This review explores the efficacy, mechanisms, and clinical applications of various phototherapy modalities in treating vitiligo. Narrowband ultraviolet B therapy is highlighted as the most effective and widely used phototherapeutic option, promoting melanocyte proliferation and migration. Excimer laser, another phototherapy modality, offers targeted treatment with fewer side effects and has shown success in localized vitiligo. Additionally, combination therapies involving phototherapy and topical and systemic agents (such as psoralens, corticosteroids, calcineurin inhibitors, azathioprine, and other systemic immunomodulators, basic fibroblast growth factor/decapeptide and Janus kinase inhibitors) and surgical management have demonstrated enhanced repigmentation outcomes. The safety profile of phototherapy, including potential risks such as photodamage and carcinogenesis, is critically analyzed. The review underscores the importance of individualized treatment plans and ongoing research to optimize phototherapy protocols, ultimately aiming to improve the quality of life for vitiligo patients. |
| format | Article |
| id | doaj-art-cc869859e7ae4261a0114871df1a44e6 |
| institution | Kabale University |
| issn | 2349-5782 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Pigment International |
| spelling | doaj-art-cc869859e7ae4261a0114871df1a44e62025-02-08T05:39:57ZengWolters Kluwer Medknow PublicationsPigment International2349-57822024-12-0111315116610.4103/pigmentinternational_52_24Phototherapy in vitiligoAnuradha BishnoiIltefat HamzaviVitiligo is a chronic dermatological condition characterized by the progressive loss of melanocytes, leading to depigmented patches on the skin. Phototherapy has emerged as a cornerstone in the management of vitiligo, offering a promising approach to disease stabilization and repigmentation. This review explores the efficacy, mechanisms, and clinical applications of various phototherapy modalities in treating vitiligo. Narrowband ultraviolet B therapy is highlighted as the most effective and widely used phototherapeutic option, promoting melanocyte proliferation and migration. Excimer laser, another phototherapy modality, offers targeted treatment with fewer side effects and has shown success in localized vitiligo. Additionally, combination therapies involving phototherapy and topical and systemic agents (such as psoralens, corticosteroids, calcineurin inhibitors, azathioprine, and other systemic immunomodulators, basic fibroblast growth factor/decapeptide and Janus kinase inhibitors) and surgical management have demonstrated enhanced repigmentation outcomes. The safety profile of phototherapy, including potential risks such as photodamage and carcinogenesis, is critically analyzed. The review underscores the importance of individualized treatment plans and ongoing research to optimize phototherapy protocols, ultimately aiming to improve the quality of life for vitiligo patients.https://journals.lww.com/10.4103/pigmentinternational_52_24vitiligophototherapynbuvbexcimer |
| spellingShingle | Anuradha Bishnoi Iltefat Hamzavi Phototherapy in vitiligo Pigment International vitiligo phototherapy nbuvb excimer |
| title | Phototherapy in vitiligo |
| title_full | Phototherapy in vitiligo |
| title_fullStr | Phototherapy in vitiligo |
| title_full_unstemmed | Phototherapy in vitiligo |
| title_short | Phototherapy in vitiligo |
| title_sort | phototherapy in vitiligo |
| topic | vitiligo phototherapy nbuvb excimer |
| url | https://journals.lww.com/10.4103/pigmentinternational_52_24 |
| work_keys_str_mv | AT anuradhabishnoi phototherapyinvitiligo AT iltefathamzavi phototherapyinvitiligo |