The influence of newly synthesized tellurium-containing cyanine dyes on the intensity of oxidative processes in the bodies of mammals
The purpose of this work was to study the influence of new synthesized organotellurium compounds (TOCs) on the intensity of oxidative processes in the body of mammals – in this case, the blood and liver of rats.The experiments were performed on white outbred rats, which were given a single dose of v...
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Kamerton
2024-04-01
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| Series: | Юг России: экология, развитие |
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| Online Access: | https://ecodag.elpub.ru/ugro/article/view/3068 |
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| author | A. I. Israpilova A. M. Dzhafarova A. A. Adieva G. M. Abakarov N. O. Guseynova U. Y. Khalimbekova M. D. Astaeva K. S. Bekshokov |
| author_facet | A. I. Israpilova A. M. Dzhafarova A. A. Adieva G. M. Abakarov N. O. Guseynova U. Y. Khalimbekova M. D. Astaeva K. S. Bekshokov |
| author_sort | A. I. Israpilova |
| collection | DOAJ |
| description | The purpose of this work was to study the influence of new synthesized organotellurium compounds (TOCs) on the intensity of oxidative processes in the body of mammals – in this case, the blood and liver of rats.The experiments were performed on white outbred rats, which were given a single dose of various TOC derivatives (0.01 g/kg). The next day, the animals were decapitated, blood was collected and the liver was isolated. The content of products of oxidative modification of lipids and proteins, as well as the low molecular weight antioxidant glutathione, was determined in blood plasma, erythrocytes and liver homogenate.It was found that all TOC derivatives studied significantly increase the intensity of lipid peroxidation in erythrocytes and hepatocytes, as evidenced by a multiple increase in the concentration of malondialdehyde (MDA) in them. At the same time, TOC suppresses the levels of oxidative damage to liver proteins, which is expressed in a significant decrease in the content of carbonyl groups. A study of glutathione content in the rat erythrocytes showed the absence of any significant effects of TOS on this antioxidant in erythrocytes.However, changes in its concentration were found in the liver, which depend on the nature of TOS (for TOS1 and TOS3 a decrease and for TOS2 a slight increase). Newly synthesized TOC demonstrate pronounced prooxidant properties, significantly increasing the intensity of oxidative processes in lipids, which makes them promising agents for antibacterial, antiviral and antitumor therapy. |
| format | Article |
| id | doaj-art-cc826675e16840768dc0e0d061a73aba |
| institution | Kabale University |
| issn | 1992-1098 2413-0958 |
| language | Russian |
| publishDate | 2024-04-01 |
| publisher | Kamerton |
| record_format | Article |
| series | Юг России: экология, развитие |
| spelling | doaj-art-cc826675e16840768dc0e0d061a73aba2025-08-20T03:43:40ZrusKamertonЮг России: экология, развитие1992-10982413-09582024-04-01191859410.18470/1992-1098-2024-1-91366The influence of newly synthesized tellurium-containing cyanine dyes on the intensity of oxidative processes in the bodies of mammalsA. I. Israpilova0A. M. Dzhafarova1A. A. Adieva2G. M. Abakarov3N. O. Guseynova4U. Y. Khalimbekova5M. D. Astaeva6K. S. Bekshokov7Precaspian Institute of Biological Resources, Dagestan Federal Research Centre, Russian Academy of SciencesDagestan State University, Makhachkala, Russia 3Dagestan State Technical UniversityPrecaspian Institute of Biological Resources, Dagestan Federal Research Centre, Russian Academy of SciencesDagestan State Technical UniversityDagestan State University, Makhachkala, Russia 3Dagestan State Technical UniversityDagestan State Medical UniversityDagestan State UniversityDagestan State University, Makhachkala, RussiaThe purpose of this work was to study the influence of new synthesized organotellurium compounds (TOCs) on the intensity of oxidative processes in the body of mammals – in this case, the blood and liver of rats.The experiments were performed on white outbred rats, which were given a single dose of various TOC derivatives (0.01 g/kg). The next day, the animals were decapitated, blood was collected and the liver was isolated. The content of products of oxidative modification of lipids and proteins, as well as the low molecular weight antioxidant glutathione, was determined in blood plasma, erythrocytes and liver homogenate.It was found that all TOC derivatives studied significantly increase the intensity of lipid peroxidation in erythrocytes and hepatocytes, as evidenced by a multiple increase in the concentration of malondialdehyde (MDA) in them. At the same time, TOC suppresses the levels of oxidative damage to liver proteins, which is expressed in a significant decrease in the content of carbonyl groups. A study of glutathione content in the rat erythrocytes showed the absence of any significant effects of TOS on this antioxidant in erythrocytes.However, changes in its concentration were found in the liver, which depend on the nature of TOS (for TOS1 and TOS3 a decrease and for TOS2 a slight increase). Newly synthesized TOC demonstrate pronounced prooxidant properties, significantly increasing the intensity of oxidative processes in lipids, which makes them promising agents for antibacterial, antiviral and antitumor therapy.https://ecodag.elpub.ru/ugro/article/view/3068organotellurium compoundsmalondialdehydecarbonyl groupsglutathioneoxidative processestissuesmammalsrats |
| spellingShingle | A. I. Israpilova A. M. Dzhafarova A. A. Adieva G. M. Abakarov N. O. Guseynova U. Y. Khalimbekova M. D. Astaeva K. S. Bekshokov The influence of newly synthesized tellurium-containing cyanine dyes on the intensity of oxidative processes in the bodies of mammals Юг России: экология, развитие organotellurium compounds malondialdehyde carbonyl groups glutathione oxidative processes tissues mammals rats |
| title | The influence of newly synthesized tellurium-containing cyanine dyes on the intensity of oxidative processes in the bodies of mammals |
| title_full | The influence of newly synthesized tellurium-containing cyanine dyes on the intensity of oxidative processes in the bodies of mammals |
| title_fullStr | The influence of newly synthesized tellurium-containing cyanine dyes on the intensity of oxidative processes in the bodies of mammals |
| title_full_unstemmed | The influence of newly synthesized tellurium-containing cyanine dyes on the intensity of oxidative processes in the bodies of mammals |
| title_short | The influence of newly synthesized tellurium-containing cyanine dyes on the intensity of oxidative processes in the bodies of mammals |
| title_sort | influence of newly synthesized tellurium containing cyanine dyes on the intensity of oxidative processes in the bodies of mammals |
| topic | organotellurium compounds malondialdehyde carbonyl groups glutathione oxidative processes tissues mammals rats |
| url | https://ecodag.elpub.ru/ugro/article/view/3068 |
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